{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:04:30Z","timestamp":1789567470797,"version":"build-2803163510"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372522"],"award-info":[{"award-number":["32372522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2108085MC104"],"award-info":[{"award-number":["2108085MC104"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH050929"],"award-info":[{"award-number":["2022AH050929"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The diamondback moth Plutella xylostella is a major agricultural pest with severe insecticide resistance. Entomopathogenic fungi (EPF) serve as eco-friendly biocontrol. Insects rely on immunity to resist fungal invasion, while the regulatory mechanism of long non-coding RNAs (lncRNAs) in insect antifungal immunity remains unclear. Here, lncRNA-mediated immune responses of P. xylostella against EPF Isaria cicadae were explored. RNA-seq identified 33,402 lncRNAs, 97 of which were predicted to cis-regulate 72 immune genes. The lnc40766 targets Toll-like receptor 6 (TLR6); both were upregulated post-fungal infection, whereas miR14-3p was downregulated. Biochemical assays verified the binding relationships among lnc40766, TLR6, and miR14-3p. RNA interference (RNAi) assays indicate that TLR6 plays an important role in the Toll pathway, and lnc40766 enhances host antifungal defense, whereas miR14-3p negatively regulates immunity via TLR6. This study reveals a novel lnc40766-TLR6-miR14-3p regulatory pathway, providing promising targets for optimizing the EPF-based pest biocontrol.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05238","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:01:59Z","timestamp":1788807719000},"page":"28866-28878","source":"Crossref","is-referenced-by-count":0,"title":["Lnc40766-\n                    <i>TLR6<\/i>\n                    -miR14-3p Regulation\nPathway Mediates the Immunity of\n                    <i>Plutella xylostella<\/i>\n                    against Entomopathogenic Fungus\n                    <i>Isaria cicadae<\/i>"],"prefix":"10.1021","volume":"74","author":[{"given":"Yue","family":"Xing","sequence":"first","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]},{"name":"Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University) , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liang","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]},{"name":"Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University) , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Liu","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]},{"name":"Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University) , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]},{"name":"Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University) , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0994-2275","authenticated-orcid":true,"given":"Xiangli","family":"Dang","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]},{"name":"Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University) , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"2026091609091174600_cit1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1146\/annurev-ento-120811-153605","article-title":"Diamondback\nmoth ecology and management:\nproblems, progress, and prospects","volume":"58","author":"Furlong","year":"2013","journal-title":"Annu. Rev.\nEntomol."},{"key":"2026091609091174600_cit2","doi-asserted-by":"publisher","first-page":"106101","DOI":"10.1016\/j.cropro.2022.106101","article-title":"Resistance risk assessment in diamondback moth, Plutella xylostella (L.) to fluxametamide","volume":"163","author":"Roy","year":"2023","journal-title":"Crop\nProt."},{"key":"2026091609091174600_cit3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/bs.adgen.2016.01.006","article-title":"Entomopathogenic\nfungi: New insights into host-pathogen interactions","volume":"94","author":"Butt","year":"2016","journal-title":"Adv. Genet."},{"key":"2026091609091174600_cit4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.biocontrol.2013.06.017","article-title":"Advances in fundamental\nand applied studies in China\nof fungal biocontrol agents for use against arthropod pests","volume":"68","author":"Wang","year":"2014","journal-title":"Biol. Control"},{"key":"2026091609091174600_cit5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","article-title":"The host defense of Drosophila melanogaster","volume":"25","author":"Lemaitre","year":"2007","journal-title":"Annu. Rev.\nImmunol."},{"key":"2026091609091174600_cit6","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1139\/cjm-2019-0129","article-title":"Identification and characterization\nof the glycoside\nhydrolase family 18 genes from the entomopathogenic fungus Isaria cicadae genome","volume":"66","author":"Peng","year":"2020","journal-title":"Can. J. Microbiol."},{"key":"2026091609091174600_cit7","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs:\ndefinitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026091609091174600_cit8","doi-asserted-by":"publisher","first-page":"823403","DOI":"10.3389\/fcimb.2021.823403","article-title":"Wolbachia utilizes lncRNAs to activate the anti-dengue\nToll pathway and balance reactive oxygen species stress in Aedes aegypti through a competitive endogenous RNA network","volume":"11","author":"Mao","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2026091609091174600_cit9","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.3390\/ijms24032605","article-title":"Recent advances and\nfuture potential of long non-coding RNAs in insects","volume":"24","author":"Zafar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026091609091174600_cit10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s42003-025-09347-3","article-title":"The landscape\nand evolutionary dynamics of derived lncRNAs in insects","volume":"9","author":"Jing","year":"2026","journal-title":"Commun. Biol."},{"key":"2026091609091174600_cit11","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/imb.12756","article-title":"LncRNA-IRAR-mediated\nregulation of\ninsulin receptor transcripts in Drosophila melanogaster during nutritional stress","volume":"31","author":"Chen","year":"2022","journal-title":"Insect Mol. Biol."},{"key":"2026091609091174600_cit12","doi-asserted-by":"publisher","first-page":"109732","DOI":"10.1016\/j.isci.2024.109732","article-title":"Long noncoding RNAs heat shock RNA omega nucleates\nTBPH and promotes intestinal stem cell differentiation upon heat shock","volume":"27","author":"Guo","year":"2024","journal-title":"iScience"},{"key":"2026091609091174600_cit13","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.bbrc.2019.06.107","article-title":"An antisense\nlncRNA functions in\nalternative splicing of Bmdsx in the silkworm, Bombyx mori","volume":"516","author":"Xu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026091609091174600_cit14","doi-asserted-by":"publisher","first-page":"101280","DOI":"10.1016\/j.cbd.2024.101280","article-title":"Whole transcriptome\nanalysis identifies differentially expressed\nmRNA, miRNA and lncRNA associated with male sterility in the silkworm, Bombyx mori","volume":"52","author":"Huang","year":"2024","journal-title":"Comp. Biochem. Physiol.\nPart D Genomics Proteomics"},{"key":"2026091609091174600_cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007504","article-title":"Immune-inducible non-coding RNA molecule\nlincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster","volume":"15","author":"Valanne","year":"2019","journal-title":"PLoS Pathog."},{"key":"2026091609091174600_cit16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.chom.2019.12.006","article-title":"LncRNA sensing of a\nviral suppressor of RNAi activates non-canonical\ninnate immune signaling in Drosophila","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Host Microbe"},{"key":"2026091609091174600_cit17","doi-asserted-by":"publisher","first-page":"10117","DOI":"10.3390\/ijms221810117","article-title":"LncRNA-CR11538 decoys\nDif\/Dorsal to Reduce antimicrobial peptide products for restoring Drosophila Toll immunity homeostasis","volume":"22","author":"Zhou","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026091609091174600_cit18","doi-asserted-by":"publisher","first-page":"104183","DOI":"10.1016\/j.dci.2021.104183","article-title":"lncRNA-CR46018\npositively regulates the Drosophila Toll immune response\nby interacting with Dif\/Dorsal","volume":"124","author":"Zhou","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"2026091609091174600_cit19","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.4049\/jimmunol.2100658","article-title":"Interaction\nof lncRNA-CR33942 with Dif\/Dorsal facilitates antimicrobial peptide\ntranscriptions and enhances Drosophila Toll immune\nresponses","volume":"208","author":"Zhou","year":"2022","journal-title":"J. Immunol."},{"key":"2026091609091174600_cit20","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/imb.12760","article-title":"Cellular lnc_209997 suppresses Bombyx mori nucleopolyhedrovirus replication by targeting miR-275-5p in B. mori","volume":"31","author":"Lin","year":"2022","journal-title":"Insect Mol. Biol."},{"key":"2026091609091174600_cit21","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/imb.12821","article-title":"LincRNA_XR209691.3 could promote Bombyx mori nucleopolyhedrovirus replication by interacting with\nBmHSP70","volume":"32","author":"Lin","year":"2023","journal-title":"Insect Mol. Biol."},{"key":"2026091609091174600_cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009888","article-title":"Regulation of GSTu1-mediated\ninsecticide resistance in Plutella xylostella by\nmiRNA and lncRNA","volume":"17","author":"Zhu","year":"2021","journal-title":"PLoS Genet."},{"key":"2026091609091174600_cit23","doi-asserted-by":"publisher","first-page":"15870","DOI":"10.1038\/s41598-017-16057-2","article-title":"Genome-wide identification\nof long non-coding RNA genes and their association with insecticide\nresistance and metamorphosis in diamondback moth, Plutella xylostella","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"2026091609091174600_cit24","doi-asserted-by":"publisher","first-page":"916","DOI":"10.3390\/insects13100916","article-title":"Analysis of long non-coding\nRNA-mediated regulatory networks of Plutella xylostella in response to Metarhizium anisopliae infection","volume":"13","author":"Zafar","year":"2022","journal-title":"Insects"},{"key":"2026091609091174600_cit25","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","article-title":"The dorsoventral regulatory gene\ncassette spa\u0308tzle\/Toll\/Cactus controls the\npotent antifungal response in Drosophila adults","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell"},{"key":"2026091609091174600_cit26","doi-asserted-by":"publisher","first-page":"649","DOI":"10.4049\/jimmunol.1002302","article-title":"The Drosophila toll\nsignaling pathway","volume":"186","author":"Valanne","year":"2011","journal-title":"J. Immunol."},{"key":"2026091609091174600_cit27","doi-asserted-by":"publisher","first-page":"139417","DOI":"10.1016\/j.ijbiomac.2024.139417","article-title":"MiR8523 negatively\nregulates the immunity of Plutella xylostella against\nentomopathogenic fungus Isaria cicadae by targeting PxSpz5","volume":"293","author":"Xu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"2026091609091174600_cit28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3389\/fbioe.2020.00331","article-title":"Comparative transcriptome analysis\nreveals new lncRNAs responding\nto salt stress in sweet sorghum","volume":"8","author":"Sun","year":"2020","journal-title":"Front. Bioeng.\nBiotechnol."},{"key":"2026091609091174600_cit29","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation\nby\nlong non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026091609091174600_cit30","doi-asserted-by":"publisher","first-page":"W12","DOI":"10.1093\/nar\/gkx428","article-title":"CPC2: a fast and accurate\ncoding potential calculator\nbased on sequence intrinsic features","volume":"45","author":"Kang","year":"2017","journal-title":"Nucleic\nAcids Res."},{"key":"2026091609091174600_cit31","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis\nof relative gene expression data using real-time\nquantitative PCR and the 2\u2013\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2026091609091174600_cit32","doi-asserted-by":"publisher","first-page":"103413","DOI":"10.1016\/j.ibmb.2020.103413","article-title":"lincRNA_Tc13743.2-miR-133-5p-TcGSTm02\nregulation pathway mediates\ncyflumetofen resistance in Tetranychus cinnabarinus","volume":"123","author":"Feng","year":"2020","journal-title":"Insect Biochem. Mol. Biol."},{"key":"2026091609091174600_cit33","doi-asserted-by":"publisher","first-page":"12654","DOI":"10.1073\/pnas.231471798","article-title":"Drosophila MyD88\nis an adapter in\nthe Toll signaling pathway","volume":"98","author":"Horng","year":"2001","journal-title":"Proc. Natl. Acad.\nSci. U.S.A."},{"key":"2026091609091174600_cit34","doi-asserted-by":"publisher","first-page":"4585","DOI":"10.1002\/ps.70575","article-title":"Risk assessment of\nisocycloseram: resistance development in Plutella xylostella and selective toxicity to the predatory stink bug Arma chinensis","volume":"82","author":"Sun","year":"2026","journal-title":"Pest Manag. Sci."},{"key":"2026091609091174600_cit35","doi-asserted-by":"publisher","first-page":"1504175","DOI":"10.3389\/fmicb.2024.1504175","article-title":"Editorial: Role of entomopathogenic\nfungi in sustainable agriculture","volume":"15","author":"Vivekanandhan","year":"2024","journal-title":"Front. Microbiol."},{"key":"2026091609091174600_cit36","doi-asserted-by":"publisher","first-page":"23330","DOI":"10.1038\/srep23330","article-title":"Genome-wide identification and developmental\nexpression profiling\nof long noncoding RNAs during Drosophila metamorphosis","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"2026091609091174600_cit37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147147","article-title":"Systematic identification\nand characterization of long\nnon-coding RNAs in the silkworm, Bombyx mori","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"key":"2026091609091174600_cit38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005069","article-title":"Identification of Aedes\naegypti long intergenic non-coding RNAs and their association with Wolbachia and dengue virus infection","volume":"10","author":"Etebari","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2026091609091174600_cit39","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1111\/1744-7917.12867","article-title":"Genome-wide identification and characterization of long non-coding\nRNAs in Tribolium castaneum","volume":"28","author":"Yang","year":"2021","journal-title":"Insect Sci."},{"key":"2026091609091174600_cit40","doi-asserted-by":"publisher","first-page":"104972","DOI":"10.1016\/j.pestbp.2021.104972","article-title":"Identification and the\npotential roles of long non-coding RNAs in\nregulating acetyl-CoA carboxylase ACC transcription in spirotetramat-resistant Aphis gossypii","volume":"179","author":"Peng","year":"2021","journal-title":"Pestic. Biochem. Phys."},{"key":"2026091609091174600_cit41","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13587","article-title":"Genome-wide identification of long non-coding (lncRNA)\nin Nilaparvata lugens\u2019s adaptability to resistant\nrice","volume":"10","author":"Zha","year":"2022","journal-title":"PeerJ"},{"key":"2026091609091174600_cit42","doi-asserted-by":"publisher","first-page":"001827","DOI":"10.1099\/jgv.0.001827","article-title":"Genome-wide identification of lncRNAs associated with\nviral infection in Spodoptera frugiperda","volume":"104","author":"Robin","year":"2023","journal-title":"J. Gen. Virol."},{"key":"2026091609091174600_cit43","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ygeno.2017.08.003","article-title":"Genome-wide\nidentification and characterization of putative lncRNAs\nin the diamondback moth, Plutella xylostella (L.)","volume":"110","author":"Wang","year":"2018","journal-title":"Genomics"},{"key":"2026091609091174600_cit44","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1186\/s12864-017-3748-9","article-title":"Genome-wide identiffcation\nof lncRNAsassociated with chlorantraniliprole resistance in diamondback\nmoth Plutella xylostella (L.)","volume":"18","author":"Zhu","year":"2017","journal-title":"BMC Genom"},{"key":"2026091609091174600_cit45","doi-asserted-by":"publisher","first-page":"5092","DOI":"10.1038\/s41467-019-13075-8","article-title":"Regulation\nof CHD2 expression by the Chaserr long noncoding RNA gene is essential\nfor viability","volume":"10","author":"Rom","year":"2019","journal-title":"Nat. Commun."},{"key":"2026091609091174600_cit46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/ni747","article-title":"Drosophila MyD88 is required for the response to fungal\nand Gram-positive bacterial infections","volume":"3","author":"Tauszig-Delamasure","year":"2002","journal-title":"Nat.\nImmunol."},{"key":"2026091609091174600_cit47","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors\nand their crosstalk with other innate receptors\nin infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"2026091609091174600_cit48","doi-asserted-by":"publisher","first-page":"9877","DOI":"10.1038\/srep09877","article-title":"Genome-wide\ncharacterization and expression profiling of immune genes in the diamondback\nmoth, Plutella xylostella (L.)","volume":"5","author":"Xia","year":"2015","journal-title":"Sci. Rep."},{"key":"2026091609091174600_cit49","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.tig.2021.09.006","article-title":"The Toll gene\nin Drosophila pattern formation","volume":"38","author":"Nu\u0308sslein-Volhard","year":"2022","journal-title":"Trends Genet."},{"key":"2026091609091174600_cit50","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.3390\/ijms20184646","article-title":"Insights into the functions\nof lncRNAs in Drosophila","volume":"20","author":"Li","year":"2019","journal-title":"Int.\nJ. Mol. Sci."},{"key":"2026091609091174600_cit51","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1042\/CS20181061","article-title":"A novel lncRNA NR4A1AS up-regulates orphan nuclear\nreceptor NR4A1\nexpression by blocking UPF1-mediated mRNA destabilization in colorectal\ncancer","volume":"133","author":"Xie","year":"2019","journal-title":"Clin. Sci."},{"key":"2026091609091174600_cit52","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.ymthe.2019.05.023","article-title":"PTB-AS, a novel natural antisense transcript, promotes glioma progression\nby improving PTBP1 mRNA stability with SND1","volume":"27","author":"Zhu","year":"2019","journal-title":"Mol. Ther."},{"key":"2026091609091174600_cit53","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.ncrna.2024.06.002","article-title":"New mechanism of LncRNA:\nIn addition to act as a ceRNA","volume":"9","author":"Zhang","year":"2024","journal-title":"Noncoding RNA\nRes."},{"key":"2026091609091174600_cit54","doi-asserted-by":"publisher","first-page":"6845","DOI":"10.1093\/nar\/gkr330","article-title":"Experimental\nstrategies for microRNA\ntarget identification","volume":"39","author":"Thomson","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2026091609091174600_cit55","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2741\/4917","article-title":"Emerging roles of microRNAs in the\nregulation of Toll-like receptor (TLR)-signaling","volume":"26","author":"Banerjee","year":"2021","journal-title":"Front. Biosci."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c05238","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/36\/28866\/68427282\/acs.jafc.6c05238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/36\/28866\/68427282\/acs.jafc.6c05238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:13:04Z","timestamp":1789564384000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/36\/28866\/5424724\/Lnc40766-TLR6-miR14-3p-Regulation-Pathway-Mediates"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":55,"journal-issue":{"issue":"36","published-online":{"date-parts":[[2026,9,7]]},"published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c05238","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]}}}