{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:05:08Z","timestamp":1789567508842,"version":"build-2803163510"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-40"],"award-info":[{"award-number":["CARS-40"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301991"],"award-info":[{"award-number":["32301991"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study constructed a peptide-calcium chelate (LHDVK-Ca) using the duck plasma-derived pentapeptide LHDVK to investigate its binding mechanism, stability, and intestinal transport behavior. Spectroscopic analysis combined with isothermal titration calorimetry (ITC) revealed that LHDVK binds Ca2+ primarily through the carboxyl group of the aspartic acid residue with a single binding site and moderate affinity. Molecular simulations confirmed that Asp plays a dominant role in coordinating Ca2+. The chelate exhibited enhanced thermal stability and maintained high calcium retention under simulated gastrointestinal conditions. LHDVK-Ca markedly enhanced calcium absorption and translocation in Caco-2 cells by increasing TRPV6, Calbindin D9k, and PMCA1b expression, suggesting a TRPV6-dependent transcellular pathway. This study provides new evidence that short peptides derived from underutilized poultry byproducts can form stable calcium chelates with preferential binding sites and promote intestinal calcium transport through regulation of calcium-related pathways, offering potential for functional food applications.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05327","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:12:57Z","timestamp":1788451977000},"page":"28471-28482","source":"Crossref","is-referenced-by-count":0,"title":["Structure, Stability,\nand Calcium Transport Mechanism\nof a Novel Duck Plasma Peptide-Calcium Chelate (LHDVK-Ca)"],"prefix":"10.1021","volume":"74","author":[{"given":"Zhiyu","family":"Li","sequence":"first","affiliation":[{"name":"Ministry of Science and Technology , , ,","place":["Nanjing, P. R. China, 210014"]},{"name":"Huaiyin Institute of Technology , , , ,","place":["Huaian, Jiangsu, P. R. China, 223003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Jiangsu Academy of Agricultural Sciences , , , ,","place":["Nanjing, Jiangsu, P. R. China, 210014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Academy of Agricultural Sciences , , , ,","place":["Nanjing, Jiangsu, P. R. China, 210014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cancan","family":"Luo","sequence":"additional","affiliation":[{"name":"Jiangsu Academy of Agricultural Sciences , , , ,","place":["Nanjing, Jiangsu, P. R. China, 210014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiulan","family":"Peng","sequence":"additional","affiliation":[{"name":"Jiangsu Academy of Agricultural Sciences , , , ,","place":["Nanjing, Jiangsu, P. R. China, 210014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Academy of Agricultural Sciences , , , ,","place":["Nanjing, Jiangsu, P. R. China, 210014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoying","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Academy of Agricultural Sciences , , , ,","place":["Nanjing, Jiangsu, P. R. China, 210014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-8877","authenticated-orcid":true,"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Ministry of Science and Technology , , ,","place":["Nanjing, P. R. China, 210014"]},{"name":"Jiangsu Academy of Agricultural Sciences , , , ,","place":["Nanjing, Jiangsu, P. R. China, 210014"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026091609091444400_cit1","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.3390\/nu15132829","article-title":"Dietary calcium\nintake and osteoporosis risk in Arab adults","volume":"15","author":"Al-Daghri","year":"2023","journal-title":"Nutrients"},{"key":"2026091609091444400_cit2","doi-asserted-by":"publisher","first-page":"134335","DOI":"10.1016\/j.foodchem.2022.134335","article-title":"Glycosylated peptide-calcium\nchelate: Characterization, calcium absorption promotion and prebiotic\neffect","volume":"403","author":"Wu","year":"2023","journal-title":"Food Chem."},{"key":"2026091609091444400_cit3","doi-asserted-by":"publisher","first-page":"104595","DOI":"10.1016\/j.tifs.2024.104595","article-title":"Food-derived\ncalcium chelating peptides: Biological\nfunctional components for better calcium bioavailability","volume":"150","author":"Wu","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"2026091609091444400_cit4","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1556\/066.2019.48.4.8","article-title":"Rapid enrichment\nof peptides with calcium-chelating capacity and characterization of\nphysical chemical properties","volume":"48","author":"Wu","year":"2019","journal-title":"Acta Aliment."},{"key":"2026091609091444400_cit5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.procbio.2023.03.031","article-title":"Casein calcium-binding peptides:\nPreparation, characterization, and\npromotion of calcium uptake in Caco-2 cell monolayers","volume":"130","author":"Lao","year":"2023","journal-title":"Process Biochem."},{"key":"2026091609091444400_cit6","doi-asserted-by":"publisher","first-page":"106898","DOI":"10.1016\/j.jff.2025.106898","article-title":"Unraveling amino acid sequence features\nthat confer high calcium-binding\ncapacity to soybean peptides and improve absorption in Caco-2 cells","volume":"130","author":"An","year":"2025","journal-title":"J. Funct. Foods"},{"key":"2026091609091444400_cit7","doi-asserted-by":"publisher","first-page":"135387","DOI":"10.1016\/j.foodchem.2023.135387","article-title":"A novel calcium-binding\npeptide from bovine bone collagen hydrolysate and chelation mechanism\nand calcium absorption activity of peptide-calcium chelate","volume":"410","author":"Qi","year":"2023","journal-title":"Food Chem."},{"key":"2026091609091444400_cit8","doi-asserted-by":"publisher","first-page":"11970","DOI":"10.1021\/acs.jafc.3c03256","article-title":"Purification, identification, chelation mechanism,\nand calcium absorption\nactivity of a novel calcium-binding peptide from peanut (arachis hypogaea)\nprotein hydrolysate","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"2026091609091444400_cit9","doi-asserted-by":"publisher","first-page":"8569","DOI":"10.1021\/acs.jafc.3c09916","article-title":"Characterization and mechanism of\na novel rice protein peptide (ahvgmsgeepe)\ncalcium chelate in enhancing calcium absorption in Caco-2 cells","volume":"72","author":"Yang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"2026091609091444400_cit10","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00424-021-02648-6","article-title":"Colonic\nexpression of calcium transporter TRPV6 is regulated by dietary sodium\nbutyrate","volume":"474","author":"Gommers","year":"2022","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"key":"2026091609091444400_cit11","doi-asserted-by":"publisher","first-page":"7159","DOI":"10.1016\/j.psj.2020.08.060","article-title":"Investigation of optimal\nconditions for production of antioxidant peptides from duck blood\nplasma: Response surface methodology","volume":"99","author":"Yang","year":"2020","journal-title":"Poultry\nSci."},{"key":"2026091609091444400_cit12","doi-asserted-by":"publisher","first-page":"145809","DOI":"10.1016\/j.foodchem.2025.145809","article-title":"Discovery\nof novel calcium-chelating peptides from antarctic krill: Structural\nelucidation and dynamic coordination mechanisms","volume":"493","author":"Fan","year":"2025","journal-title":"Food Chem."},{"key":"2026091609091444400_cit13","doi-asserted-by":"publisher","first-page":"126534","DOI":"10.1016\/j.foodchem.2020.126534","article-title":"Purification\nand identification of\nantioxidant peptides from duck plasma proteins","volume":"319","author":"Yang","year":"2020","journal-title":"Food Chem."},{"key":"2026091609091444400_cit14","doi-asserted-by":"publisher","first-page":"137864","DOI":"10.1016\/j.ijbiomac.2024.137864","article-title":"Enzymatic\nhydrolysis of duck blood protein produces stable bioactive peptides:\nPilot-scale production, identification, and stability during gastrointestinal\nand plasma digestion","volume":"283","author":"Laosam","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026091609091444400_cit15","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.3390\/foods13152368","article-title":"Preparation, characterization\nand stability of calcium-binding peptides\nderived from chicken blood","volume":"13","author":"Yang","year":"2024","journal-title":"Foods"},{"key":"2026091609091444400_cit16","doi-asserted-by":"publisher","first-page":"139268","DOI":"10.1016\/j.foodchem.2024.139268","article-title":"Isolation and differential structure\ncharacteristics of calcium-binding peptides derived from pacific cod\nbones by hydroxyapatite affinity","volume":"451","author":"Tian","year":"2024","journal-title":"Food Chem."},{"key":"2026091609091444400_cit17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"Gromacs: High\nperformance\nmolecular simulations through multi-level parallelism from laptops\nto supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"2026091609091444400_cit18","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1002\/prot.22711","article-title":"Improved side-chain\ntorsion potentials for the amber ff99sb protein force field","volume":"78","author":"Lindorff-Larsen","year":"2010","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"2026091609091444400_cit19","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3390\/foods12051058","article-title":"Process optimization, structural characterization, and calcium release\nrate evaluation of mung bean peptides-calcium chelate","volume":"12","author":"Zhai","year":"2023","journal-title":"Foods"},{"key":"2026091609091444400_cit20","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1038\/nprot.2007.303","article-title":"Determination\nof drug permeability\nand prediction of drug absorption in Caco-2 monolayers","volume":"2","author":"Hubatsch","year":"2007","journal-title":"Nat. Protoc."},{"key":"2026091609091444400_cit21","doi-asserted-by":"publisher","first-page":"149025","DOI":"10.1016\/j.ijbiomac.2025.149025","article-title":"Calcium-loaded\nlipopeptides for enhanced bioavailability and reduction of calcium\ndeficiency","volume":"334","author":"Rokhsatzadeh","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"2026091609091444400_cit22","doi-asserted-by":"publisher","first-page":"133912","DOI":"10.1016\/j.foodchem.2022.133912","article-title":"Identification\nof high\niron-chelating peptides with unusual antioxidant effect from sea cucumbers\nand the possible binding mode","volume":"399","author":"Fan","year":"2023","journal-title":"Food Chem."},{"key":"2026091609091444400_cit23","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3390\/md21110579","article-title":"Novel ca-chelating\npeptides from protein hydrolysate of antarctic\nkrill (euphausia superba): Preparation, characterization, and calcium\nabsorption efficiency in Caco-2 cell monolayer model","volume":"21","author":"Ge","year":"2023","journal-title":"Mar. Drugs"},{"key":"2026091609091444400_cit24","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.1111\/ijfs.17187","article-title":"Egg yolk peptide-iron\nchelate: Preparation,\nconformational structure, chelating mechanism and stability in vitro","volume":"59","author":"Wei","year":"2024","journal-title":"Int. J. Food Sci. Technol."},{"key":"2026091609091444400_cit25","doi-asserted-by":"publisher","first-page":"7724","DOI":"10.1039\/c9fo01383k","article-title":"The purification, identification\nand bioactivity study of a novel calcium-binding peptide from casein\nhydrolysate","volume":"10","author":"Liao","year":"2019","journal-title":"Food Funct."},{"key":"2026091609091444400_cit26","doi-asserted-by":"publisher","first-page":"112033","DOI":"10.1016\/j.foodres.2022.112033","article-title":"Calcium-chelating improved zein peptide\nstability, cellular uptake, and bioactivity by influencing the structural\ncharacterization","volume":"162","author":"Qu","year":"2022","journal-title":"Food Res. Int."},{"key":"2026091609091444400_cit27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.mce.2011.05.038","article-title":"Vitamin d\nand intestinal calcium absorption","volume":"347","author":"Christakos","year":"2011","journal-title":"Mol. Cell.\nEndocrinol."},{"key":"2026091609091444400_cit28","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1080\/10498850.2018.1449153","article-title":"Purification\nof algal calcium-chelating\npeptide and its physical chemical properties","volume":"27","author":"Zhang","year":"2018","journal-title":"J. Aquat. Food Prod. Technol."},{"key":"2026091609091444400_cit29","doi-asserted-by":"publisher","first-page":"5516","DOI":"10.1002\/jsfa.14292","article-title":"Identification of a\nnovel calcium-binding peptide from\nlentinula edodes and structure, stability and absorption evaluation\nof its calcium chelate","volume":"105","author":"Gu","year":"2025","journal-title":"J. Sci. Food Agric."},{"key":"2026091609091444400_cit30","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.foodchem.2017.02.121","article-title":"Preparation\nof cucumber seed peptide-calcium chelate by liquid state fermentation\nand its characterization","volume":"229","author":"Wang","year":"2017","journal-title":"Food Chem."},{"key":"2026091609091444400_cit31","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/1750-3841.14975","article-title":"Identification and characterization\nof the peptides with calcium-binding capacity from tilapia (oreochromis\nniloticus) skin gelatin enzymatic hydrolysates","volume":"85","author":"Bingtong","year":"2020","journal-title":"J. Food Sci."},{"key":"2026091609091444400_cit32","doi-asserted-by":"publisher","first-page":"145039","DOI":"10.1016\/j.foodchem.2025.145039","article-title":"Glycated walnut peptide-calcium\nchelates: Structural properties, calcium absorption enhancement mechanism,\nand osteogenic effects","volume":"489","author":"Wang","year":"2025","journal-title":"Food Chem."},{"key":"2026091609091444400_cit33","doi-asserted-by":"publisher","first-page":"11624","DOI":"10.1039\/D0RA00425A","article-title":"Preparation\nof sheep bone collagen peptide-calcium chelate using enzymolysis-fermentation\nmethodology and its structural characterization and stability analysis","volume":"10","author":"Wang","year":"2020","journal-title":"RSC Adv."},{"key":"2026091609091444400_cit34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/md15010003","article-title":"Novel peptide\nwith specific calcium-binding\ncapacity from schizochytrium sp protein hydrolysates and calcium bioavailability\nin Caco-2 cells","volume":"15","author":"Cai","year":"2017","journal-title":"Mar. Drugs"},{"key":"2026091609091444400_cit35","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.3390\/nu10091325","article-title":"Functional calcium\nbinding peptides from pacific cod (gadus macrocephalus)\nbone: Calcium bioavailability enhancing activity and anti-osteoporosis\neffects in the ovariectomy-induced osteoporosis rat model","volume":"10","author":"Zhang","year":"2018","journal-title":"Nutrients"},{"key":"2026091609091444400_cit36","doi-asserted-by":"publisher","first-page":"114612","DOI":"10.1016\/j.foodres.2024.114612","article-title":"Digestion and absorption characteristics of\niron-chelating\nsilver carp scale collagen peptide and insights into their chelation\nmechanism","volume":"190","author":"Zhao","year":"2024","journal-title":"Food Res. Int."},{"key":"2026091609091444400_cit37","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1021\/acs.jafc.9b07770","article-title":"Egg-white-derived antioxidant peptide\nas an efficient nanocarrier for zinc delivery through the gastrointestinal\nsystem","volume":"68","author":"Wang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"2026091609091444400_cit38","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1021\/acsfoodscitech.3c00002","article-title":"Understanding the\nfactors influencing\nthe ability of calcium-binding peptides to promote calcium absorption","volume":"3","author":"Liu","year":"2023","journal-title":"ACS Food Sci. Technol."},{"key":"2026091609091444400_cit39","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1039\/D2FO00808D","article-title":"Comment\non \u201cdeciphering calcium-binding behaviors of casein phosphopeptides\nby experimental approaches and molecular simulation\u201d by M.\nLuo, J. Xiao, S. Sun, F. Cui, G. Liu, W. Li, Y. Li and Y. Cao, Food\nFunct., 2020, 11, 5284","volume":"14","author":"Horne","year":"2023","journal-title":"Food Funct."},{"key":"2026091609091444400_cit40","doi-asserted-by":"publisher","first-page":"12283","DOI":"10.1021\/acs.jafc.9b04522","article-title":"Calcium delivery system assembled by a nanostructured peptide derived\nfrom the sea cucumber ovum","volume":"67","author":"Cui","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"2026091609091444400_cit41","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.3390\/foods11203290","article-title":"Calcium binding\nmechanism of soybean peptide with histidine alteration by molecular\ndocking analysis and spectroscopic methods","volume":"11","author":"Gan","year":"2022","journal-title":"Foods"},{"key":"2026091609091444400_cit42","doi-asserted-by":"publisher","first-page":"5924","DOI":"10.2174\/0109298673325827240926081845","article-title":"Molecular docking in drug discovery:\nTechniques, applications, and\nadvancements","volume":"32","author":"Aguiar","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"2026091609091444400_cit43","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.3390\/foods13111652","article-title":"Preparation of calcium-binding\npeptides derived from mackerel (scomber japonicus) protein and structural\ncharacterization and stability analysis of its calcium complexes","volume":"13","author":"Cui","year":"2024","journal-title":"Foods"},{"key":"2026091609091444400_cit44","doi-asserted-by":"publisher","first-page":"142900","DOI":"10.1016\/j.foodchem.2025.142900","article-title":"Insights into\ninteraction\nmechanism between fibrinogen hydrolyzed peptides and myosin during\ngelation by molecular docking and molecular dynamic simulation","volume":"472","author":"Zhang","year":"2025","journal-title":"Food Chem."},{"key":"2026091609091444400_cit45","doi-asserted-by":"publisher","first-page":"6884","DOI":"10.1002\/jsfa.12771","article-title":"Preparation, structure\ncharacterization, and stability analysis of peptide-calcium complex\nderived from porcine nasal cartilage type ii collagen","volume":"103","author":"Cui","year":"2023","journal-title":"J. Sci. Food Agric."},{"key":"2026091609091444400_cit46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.foodchem.2019.01.103","article-title":"Preparation\nprocess optimization\nof pig bone collagen peptide-calcium chelate using response surface\nmethodology and its structural characterization and stability analysis","volume":"284","author":"Wu","year":"2019","journal-title":"Food Chem."},{"key":"2026091609091444400_cit47","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1039\/d2fo02146c","article-title":"Preparation of a cattle\nbone collagen peptide-calcium chelate by the ultrasound method and\nits structural characterization, stability analysis, and bioactivity\non mc3t3-e1 cells","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct."},{"key":"2026091609091444400_cit48","doi-asserted-by":"publisher","first-page":"1129548","DOI":"10.3389\/fnut.2023.1129548","article-title":"Calcium-binding properties, stability, and osteogenic ability of\nphosphorylated soy peptide-calcium chelate","volume":"10","author":"Kong","year":"2023","journal-title":"Front. Nutr."},{"key":"2026091609091444400_cit49","doi-asserted-by":"publisher","first-page":"106497","DOI":"10.1016\/j.jff.2024.106497","article-title":"Preparation\nand characterization of sipunculus nudus peptide-calcium chelate:\nStructural insights and osteogenic bioactivity assessment","volume":"122","author":"Ouyang","year":"2024","journal-title":"J. Funct. Foods"},{"key":"2026091609091444400_cit50","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tifs.2019.12.022","article-title":"Safety considerations\non food protein-derived bioactive peptides","volume":"96","author":"Liu","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"2026091609091444400_cit51","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1002\/jsfa.8330","article-title":"Characterization of sea cucumber\n(stichopus japonicus) ovum hydrolysates: Calcium chelation, solubility\nand absorption into intestinal epithelial cells","volume":"97","author":"Sun","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"2026091609091444400_cit52","doi-asserted-by":"publisher","first-page":"106825","DOI":"10.1016\/j.fbio.2025.106825","article-title":"Identification of a\nnovel calcium transport-promoting peptide from\nphosvitin hydrolysate: Establishment of a Caco-2 cell monolayer, sequence\ndetermination, and molecular interaction analysis","volume":"69","author":"Liu","year":"2025","journal-title":"Food Biosci."},{"key":"2026091609091444400_cit53","doi-asserted-by":"publisher","first-page":"2100182","DOI":"10.1002\/mnfr.202100182","article-title":"Kfp-1, a novel calcium-binding\npeptide isolated from\nkefir, promotes calcium influx through TRPV6 channels","volume":"65","author":"Chang","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"2026091609091444400_cit54","doi-asserted-by":"publisher","first-page":"6676","DOI":"10.1002\/jsfa.13493","article-title":"Identification of calcium\nchelating peptides from peanut protein hydrolysate and absorption\nactivity of peptide-calcium complex","volume":"104","author":"Bu","year":"2024","journal-title":"J. Sci.\nFood Agric."},{"key":"2026091609091444400_cit55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277096","article-title":"Vasoactive\nintestinal peptide and cystic fibrosis transmembrane conductance regulator\ncontribute to the transepithelial calcium transport across intestinal\nepithelium-like Caco-2 monolayer","volume":"17","author":"Rodrat","year":"2022","journal-title":"PLoS One"},{"key":"2026091609091444400_cit56","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/ijms17071095","article-title":"Regulation\nof intestinal epithelial calcium transport proteins by stanniocalcin-1\nin Caco-2 cells","volume":"17","author":"Xiang","year":"2016","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c05327","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/36\/28471\/68188447\/acs.jafc.6c05327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/36\/28471\/68188447\/acs.jafc.6c05327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:17:01Z","timestamp":1789564621000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/36\/28471\/5404689\/Structure-Stability-and-Calcium-Transport"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":56,"journal-issue":{"issue":"36","published-online":{"date-parts":[[2026,9,2]]},"published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c05327","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}