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Using a reserpine-induced depression rat model, we integrated behavioral, inflammatory, histological, microbiota, metabolomic, and fecal microbiota transplantation (FMT) analyses. DMY alleviated anhedonia, behavioral despair, and cognitive dysfunction, reduced circulating pro-inflammatory cytokines and hippocampal neuronal damage, and increased brain-derived neurotrophic factor expression. DMY also restored gut microbial diversity and composition and partially normalized bile acid and short-chain fatty acid profiles. Notably, FMT from DMY-treated donors reproduced antidepressant-like behavioral effects and restored key microbial metabolites. These findings suggest that DMY may alleviate depression-like phenotypes through coordinated regulation of gut microbiota, microbial metabolites, and neuroinflammatory responses, supporting its potential as a dietary strategy for depression management.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05330","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:02:19Z","timestamp":1791784939000},"page":"32288-32308","source":"Crossref","is-referenced-by-count":0,"title":["Dihydromyricetin\nAlleviates Reserpine-Induced Depression\nby Modulating the Microbiota\u2013Gut\u2013Brain Axis"],"prefix":"10.1021","volume":"74","author":[{"given":"Zikang","family":"Wang","sequence":"first","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Liao","sequence":"additional","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural University , , ,","place":["Changsha, China, 410128"]},{"name":"Hunan Agricultural 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