{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:44:05Z","timestamp":1786538645938,"version":"build-2736575974"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2024YFD1701700"],"award-info":[{"award-number":["2024YFD1701700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["22377031"],"award-info":[{"award-number":["22377031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is a promising target for new herbicide research. To develop new HPPD-inhibiting herbicides, we used a scaffold-hopping strategy by introducing a quinazolinone ring and combining it with the classic triketone pharmacophore, designing and synthesizing a series of novel HPPD inhibitors with a fused-ring architecture. The results showed that II-series of compounds exhibited excellent inhibitory activity against Arabidopsis thaliana (At) HPPD, with IC50 values 0.5- to 2.5-fold lower than those of mesotrione. Moreover, we obtained the crystal structure of AtHPPD\u2013II-36 complex at a resolution of 1.8 \u00c5. Importantly, II-36 exhibited high safety to wheat and outstanding herbicidal efficacy against Echinochloa crus-galli, Digitaria sanguinalis, and Bromus japonicus at a dosage of 30 g ai\/ha. Our study provides a valuable example for designing novel HPPD inhibitors with enhanced herbicidal activity and improved crop selectivity.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05378","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:05:15Z","timestamp":1785852315000},"page":"24185-24197","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Triketone-Quinazolinone\nHybrids as Novel\n4-Hydroxyphenylpyruvate Dioxygenase Inhibitors"],"prefix":"10.1021","volume":"74","author":[{"given":"Wan-Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P.R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jun","family":"Dong","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P.R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Meng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P.R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4288-7922","authenticated-orcid":true,"given":"Rui-Ning","family":"Ying","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P.R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Mei","family":"Cai","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P.R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P.R. 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China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"issue":"6390","key":"2026081208100672700_cit1","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1126\/science.aar3780","article-title":"Wicked evolution: Can we address\nthe sociobiological dilemma of pesticide resistance?","volume":"360","author":"Gould","year":"2018","journal-title":"Science"},{"issue":"1","key":"2026081208100672700_cit2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/nph.15723","article-title":"Evolutionary\nand ecological insights from herbicide-resistant weeds: what have\nwe learned about plant adaptation, and what is left to uncover?","volume":"223","author":"Baucom","year":"2019","journal-title":"New Phytol"},{"key":"2026081208100672700_cit3","unstructured":"Heap, I.\n          \n          The International Herbicide-Resistant\nWeed Database. 2026https:\/\/www.weedscience.org\/ Accessed\n17 July 2026."},{"key":"2026081208100672700_cit4","doi-asserted-by":"publisher","first-page":"2602414","DOI":"10.34133\/2019\/2602414","article-title":"Crystal Structure\nof 4-Hydroxyphenylpyruvate Dioxygenase\nin Complex with Substrate Reveals a New Starting Point for Herbicide\nDiscovery","volume":"2019","author":"Lin","year":"2019","journal-title":"Research"},{"issue":"6","key":"2026081208100672700_cit5","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.tibs.2023.02.006","article-title":"Insights\ninto 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from\ncomparative structural biology","volume":"48","author":"Lin","year":"2023","journal-title":"Trends Biochem.\nSci"},{"issue":"39","key":"2026081208100672700_cit6","doi-asserted-by":"publisher","first-page":"8523","DOI":"10.1021\/acs.jafc.7b03851","article-title":"4-Hydroxyphenylpyruvate\ndioxygenase inhibitors: from chemical biology to agrochemicals","volume":"65","author":"Ndikuryayo","year":"2017","journal-title":"J. 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