{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:43:23Z","timestamp":1792784603201,"version":"4.5.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"National Basic Research Program of China (973 Program)","award":["2024YEF0111400"],"award-info":[{"award-number":["2024YEF0111400"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["32272301"],"award-info":[{"award-number":["32272301"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intestinal barrier dysfunction is a hallmark of inflammatory bowel disease (IBD), yet effective therapies remain limited, and the mechanisms of probiotic-derived extracellular vesicles (EVs) are poorly understood. Using complementary cell, murine, and intestinal organoid models, we investigated the protective effects of Lacticaseibacillus rhamnosus ZFML003-derived EVs (ZFML003-EVs). In Caco-2 cells, ZFML003-EVs restored barrier integrity by upregulating tight junction proteins (ZO-1, Occludin, Claudin-1). In DSS-induced colitis mice, oral administration alleviated colonic pathology and suppressed pro-inflammatory cytokines (TNF-\u03b1, IL-1\u03b2, iNOS), while also restoring gut microbiota and metabolic profiles. Multi-omics analysis identified PPAR\u03b3 signaling as a key mediator, with ZFML003-EVs upregulating PPAR\u03b3 target genes (Adipoq, Scd1, Plin1). Notably, GW9662-mediated PPAR\u03b3 blockade completely abolished these effects, confirming PPAR\u03b3 dependence. Collectively, ZFML003-EVs activate PPAR\u03b3 to exert anti-inflammatory and barrier-repair effects, reshape gut microbiota and metabolism, and provide a theoretical basis for IBD-targeted therapy.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05485","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:01:57Z","timestamp":1789117317000},"page":"29224-29241","source":"Crossref","is-referenced-by-count":0,"title":["<i>Lacticaseibacillus rhamnosus<\/i>\n                    -Derived\nExtracellular Vesicles Alleviate Colitis via PPAR Signaling\nand the Gut Microbiota\u2013Metabolite Axis"],"prefix":"10.1021","volume":"74","author":[{"given":"Yingjie","family":"Huang","sequence":"first","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La","family":"Xi","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Tuo","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlan","family":"Xia","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-6615","authenticated-orcid":true,"given":"Qing","family":"Gu","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-1584","authenticated-orcid":true,"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"issue":"11","key":"2026092310081233600_cit1","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.3390\/biomedicines13112738","article-title":"The Molecular\nLandscape of Inflammation in Inflammatory Bowel Disease (IBD): Targets\nfor Precision Medicine","volume":"13","author":"Lopetuso","year":"2025","journal-title":"Biomedicines"},{"issue":"1","key":"2026092310081233600_cit2","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.1038\/s41467-022-31171-0","article-title":"Programmable probiotics\nmodulate inflammation and gut microbiota for inflammatory bowel disease\ntreatment after effective oral delivery","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat.\nCommun."},{"issue":"6478","key":"2026092310081233600_cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977","article-title":"The biology, function,\nand biomedical applications\nof exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"35","key":"2026092310081233600_cit4","doi-asserted-by":"publisher","first-page":"19259","DOI":"10.1021\/acs.jafc.4c04223","article-title":"Immunomodulatory\nEffects of Probiotic-Derived\nExtracellular Vesicles: Opportunities and Challenges","volume":"72","author":"Chen","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"2026092310081233600_cit5","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1016\/j.apsb.2025.03.008","article-title":"Bacterial\nextracellular vesicles for gut microbiome-host communication and drug\ndevelopment","volume":"15","author":"Qian","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"2026092310081233600_cit6","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","article-title":"Global\nevolution of inflammatory bowel disease across\nepidemiologic stages","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"issue":"5","key":"2026092310081233600_cit7","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1111\/brv.12608","article-title":"Exosome-mediated\neffects\nand applications in inflammatory bowel disease","volume":"95","author":"Ocansey","year":"2020","journal-title":"Biol. Rev. Cambridge Philos. Soc."},{"issue":"1","key":"2026092310081233600_cit8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12951-025-03158-8","article-title":"Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis","volume":"23","author":"Yue","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026092310081233600_cit9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41522-025-00663-4","article-title":"Bifidobacterium longum NSP001-derived extracellular\nvesicles ameliorate ulcerative colitis by modulating T cell responses\nin gut microbiota-(in)dependent manners","volume":"11","author":"Nie","year":"2025","journal-title":"npj\nBiofilms Microbiomes"},{"issue":"13","key":"2026092310081233600_cit10","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200884","article-title":"Anti-Inflammatory Effect of Clostridium\nbutyricum-Derived Extracellular Vesicles in Ulcerative Colitis: Impact\non Host microRNAs Expressions and Gut Microbiome Profiles","volume":"67","author":"Ma","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"issue":"10","key":"2026092310081233600_cit11","doi-asserted-by":"publisher","first-page":"3319","DOI":"10.3390\/nu13103319","article-title":"Lactobacillus rhamnosus GG Derived\nExtracellular Vesicles Modulate Gut Microbiota and Attenuate Inflammatory\nin DSS-Induced Colitis Mice","volume":"13","author":"Tong","year":"2021","journal-title":"Nutrients"},{"issue":"1\u20133","key":"2026092310081233600_cit12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0169-409X(00)00128-9","article-title":"Caco-2 monolayers in experimental\nand theoretical predictions of drug transport","volume":"46","author":"Artursson","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"issue":"4","key":"2026092310081233600_cit13","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1053\/j.gastro.2016.07.008","article-title":"Inflammation and the\nIntestinal Barrier:\nLeukocyte-Epithelial Cell Interactions, Cell Junction Remodeling,\nand Mucosal Repair","volume":"151","author":"Luissint","year":"2016","journal-title":"Gastroenterology"},{"key":"2026092310081233600_cit14","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines\nin inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"2026092310081233600_cit15","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.3390\/ijms24032238","article-title":"Phillygenin\nAttenuated Colon Inflammation and Improved Intestinal Mucosal Barrier\nin DSS-induced Colitis Mice via TLR4\/Src Mediated MAPK and NF-\u03baB\nSignaling Pathways","volume":"24","author":"Xue","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"2026092310081233600_cit16","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1021\/acsnano.9b09125","article-title":"Amyloid-Polyphenol\nHybrid Nanofilaments Mitigate Colitis\nand Regulate Gut Microbial Dysbiosis","volume":"14","author":"Hu","year":"2020","journal-title":"ACS Nano"},{"issue":"1","key":"2026092310081233600_cit17","doi-asserted-by":"publisher","first-page":"5283","DOI":"10.1038\/s41598-021-84761-1","article-title":"DSS-induced colitis\nis associated with adipose tissue dysfunction and disrupted hepatic\nlipid metabolism leading to hepatosteatosis and dyslipidemia in mice","volume":"11","author":"Kwon","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"2026092310081233600_cit18","doi-asserted-by":"publisher","first-page":"G171","DOI":"10.1152\/ajpgi.00048.2015","article-title":"Homeostasis\nof the gut barrier and potential biomarkers","volume":"312","author":"Wells","year":"2017","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"2026092310081233600_cit19","doi-asserted-by":"publisher","first-page":"1188455","DOI":"10.3389\/fmicb.2023.1188455","article-title":"The role of complex interactions between the intestinal\nflora and\nhost in regulating intestinal homeostasis and inflammatory bowel disease","volume":"14","author":"Li","year":"2023","journal-title":"Front. Microbiol."},{"issue":"1","key":"2026092310081233600_cit20","doi-asserted-by":"publisher","first-page":"2132903","DOI":"10.1080\/19490976.2022.2132903","article-title":"Formation of secondary\nallo-bile acids by novel enzymes\nfrom gut Firmicutes","volume":"14","author":"Lee","year":"2022","journal-title":"Gut Microbes"},{"issue":"9","key":"2026092310081233600_cit21","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria:\nmicrobial signature\nof dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"issue":"3","key":"2026092310081233600_cit22","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/s41564-025-01933-9","article-title":"ILC3s\nregulate the gut microbiota via host intestinal galactosylation to\nlimit pathogen infection in mice","volume":"10","author":"Wang","year":"2025","journal-title":"Nat. Microbiol."},{"issue":"1","key":"2026092310081233600_cit23","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s40168-024-01932-8","article-title":"Host-microbe interaction-mediated\nresistance to DSS-induced inflammatory enteritis in sheep","volume":"12","author":"Yan","year":"2024","journal-title":"Microbiome"},{"key":"2026092310081233600_cit24","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.3389\/fmicb.2018.01274","article-title":"5-Aminosalicylic Acid\nAlters the Gut Bacterial Microbiota in Patients With Ulcerative Colitis","volume":"9","author":"Xu","year":"2018","journal-title":"Front. Microbiol."},{"issue":"11","key":"2026092310081233600_cit25","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.tem.2020.05.001","article-title":"IBD Microbial Metabolome:\nThe Good, Bad, and Unknown","volume":"31","author":"Sidebottom","year":"2020","journal-title":"Trends Endocrinol.\nMetab."},{"key":"2026092310081233600_cit26","doi-asserted-by":"publisher","first-page":"107663","DOI":"10.1016\/j.phrs.2025.107663","article-title":"Lactobacillus vaginalis alleviates DSS induced colitis by regulating the\ngut microbiota and increasing the production of 3-indoleacrylic acid","volume":"213","author":"Wang","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"2","key":"2026092310081233600_cit27","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/med.21752","article-title":"Metabolites\nof microbiota response to tryptophan and intestinal mucosal immunity:\nA therapeutic target to control intestinal inflammation","volume":"41","author":"Zhang","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"8","key":"2026092310081233600_cit28","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","article-title":"Tryptophan\nmetabolism in health and disease","volume":"35","author":"Xue","year":"2023","journal-title":"Cell Metab."},{"key":"2026092310081233600_cit29","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3389\/fphar.2020.00730","article-title":"Peroxisome Proliferator-Activated\nReceptors: Experimental\nTargeting for the Treatment of Inflammatory Bowel Diseases","volume":"11","author":"Decara","year":"2020","journal-title":"Front. Pharmacol."},{"key":"2026092310081233600_cit30","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.matbio.2024.08.007","article-title":"Hyperglycemic environments\ndirectly compromise intestinal epithelial\nbarrier function in an organoid model and hyaluronan (\u223c35 kDa)\nprotects via a layilin dependent mechanism","volume":"133","author":"Jatana","year":"2024","journal-title":"Matrix Biol."},{"issue":"11","key":"2026092310081233600_cit31","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3390\/biomedicines8110522","article-title":"Extracellular Vesicles\nDerived from Kefir Grain Lactobacillus Ameliorate Intestinal Inflammation via Regulation of Proinflammatory Pathway\nand Tight Junction Integrity","volume":"8","author":"Kang","year":"2020","journal-title":"Biomedicines"},{"issue":"2","key":"2026092310081233600_cit32","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.282","article-title":"Akkermansia muciniphila-derived extracellular\nvesicles influence gut permeability through the regulation of tight\njunctions","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"2026092310081233600_cit33","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1100\/tsw.2011.22","article-title":"Anti-inflammatory and immunosuppressive\neffects of\nthe A2A adenosine receptor","volume":"11","author":"Milne","year":"2011","journal-title":"Sci.\nWorld J."},{"key":"2026092310081233600_cit34","doi-asserted-by":"publisher","first-page":"948843","DOI":"10.3389\/fonc.2022.948843","article-title":"The history of small extracellular\nvesicles and their implication in cancer drug resistance","volume":"12","author":"Palazzolo","year":"2022","journal-title":"Front. Oncol."},{"issue":"5","key":"2026092310081233600_cit35","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.it.2025.03.008","article-title":"Inflammasomopathies:\nmechanisms and disease signatures","volume":"46","author":"Cahill","year":"2025","journal-title":"Trends Immunol."},{"key":"2026092310081233600_cit36","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/B978-0-12-800267-4.00005-5","article-title":"Interleukin 10 receptor\nsignaling: master regulator of intestinal mucosal homeostasis in mice\nand humans","volume":"122","author":"Shouval","year":"2014","journal-title":"Adv. Immunol."},{"key":"2026092310081233600_cit37","doi-asserted-by":"publisher","first-page":"777147","DOI":"10.3389\/fimmu.2021.777147","article-title":"Effect of Extracellular\nVesicles Derived From Lactobacillus plantarum Q7 on Gut Microbiota and Ulcerative Colitis in\nMice","volume":"12","author":"Hao","year":"2021","journal-title":"Front. Immunol."},{"issue":"11","key":"2026092310081233600_cit38","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade5079","article-title":"Versatility of bacterial outer membrane vesicles in\nregulating intestinal homeostasis","volume":"9","author":"Wang","year":"2023","journal-title":"Sci. Adv."},{"issue":"3","key":"2026092310081233600_cit39","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00210-24","article-title":"Narrative review on bacteria-derived\nmetabolites in\nthe pathogenesis of ulcerative colitis","volume":"38","author":"Tambovtseva","year":"2025","journal-title":"Clin.\nMicrobiol. Rev."},{"issue":"1","key":"2026092310081233600_cit40","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1038\/s41467-026-69341-z","article-title":"Microbiota-derived IPA protects against colitis by regulating intestinal\nHMGCS2-mediated ketogenesis to facilitate mucosal healing","volume":"17","author":"Zhang","year":"2026","journal-title":"Nat. Commun."},{"key":"2026092310081233600_cit41","doi-asserted-by":"publisher","first-page":"13072","DOI":"10.3390\/ijms252313072","article-title":"AhR-Induced Anti-Inflammatory\nEffects on a Caco-2\/THP-1 Co-Culture Model of Intestinal Inflammation\nAre Mediated by PPAR\u03b3","volume":"25","author":"da Rocha","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"2026092310081233600_cit42","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.2337\/diabetes.52.7.1655","article-title":"Induction\nof adiponectin, a fat-derived antidiabetic and antiatherogenic factor,\nby nuclear receptors","volume":"52","author":"Iwaki","year":"2003","journal-title":"Diabetes"},{"issue":"1\u20132","key":"2026092310081233600_cit43","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cca.2007.01.026","article-title":"Adiponectin as an anti-inflammatory\nfactor","volume":"380","author":"Ouchi","year":"2007","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"2026092310081233600_cit44","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.2337\/diabetes.53.5.1243","article-title":"Adipose\ntissue expression of the lipid droplet-associating proteins S3-12\nand perilipin is controlled by peroxisome proliferator-activated receptor-gamma","volume":"53","author":"Dalen","year":"2004","journal-title":"Diabetes"},{"issue":"16","key":"2026092310081233600_cit45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2528843123","article-title":"SCD1 licenses\nSTING signaling through fatty acid desaturation-mediated membrane\nremodeling","volume":"123","author":"Qin","year":"2026","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"2026092310081233600_cit46","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s40168-020-00868-z","article-title":"Bacteroides\nthetaiotaomicron-derived outer membrane\nvesicles promote regulatory dendritic cell responses in health but\nnot in inflammatory bowel disease","volume":"8","author":"Durant","year":"2020","journal-title":"Microbiome"}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c05485","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/37\/29224\/68480509\/acs.jafc.6c05485.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/37\/29224\/68480509\/acs.jafc.6c05485.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:43:55Z","timestamp":1790178235000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/37\/29224\/5428177\/Lacticaseibacillus-rhamnosus-Derived-Extracellular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":46,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2026,9,11]]},"published-print":{"date-parts":[[2026,9,23]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c05485","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}