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Thus, a suspect screening workflow combining two complementary and platform-independent strategies in parallel, an exact mass screening tool and a combinatorial analysis of tandem mass (MS2) spectra, was developed to enhance exposure coverage. Its performance was assessed across three distinct high-resolution mass spectrometers (HRMS), using well-defined quality assurance and quality control metrics to ensure transparent and reproducible reporting of nontargeted analyses. True positive rates exceeded 80% across instruments during exact mass feature detection. Incorporating MS2-based annotation further improved identification confidence, with few false positives (\u22649). Applied to incurred bee samples, the workflow identified atrazine and two transformation products, deethylatrazine and deisopropylatrazine. Overall, this workflow provides a comprehensive framework for investigating bee poisoning incidents and represents an important step toward improving the transfer of suspect screening workflows and the comparability of HRMS data across laboratories.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05495","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:01:43Z","timestamp":1788829303000},"page":"28840-28853","source":"Crossref","is-referenced-by-count":0,"title":["Platform-Independent\nSuspect Screening Analysis of\nPesticides and Transformation Products in Honey Bees across Multiple\nHigh-Resolution Mass Spectrometers"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0447-5622","authenticated-orcid":true,"given":"Audrey","family":"Dewar","sequence":"first","affiliation":[{"name":"Universite\u0301 de Sherbrooke , , , ,","place":["Sherbrooke, QC, Canada, J1K 2R1"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pineda","sequence":"additional","affiliation":[{"name":"McGill University , , , ,","place":["Montreal, QC, Canada, H3A 0C5"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Yargeau","sequence":"additional","affiliation":[{"name":"McGill University , , , ,","place":["Montreal, QC, Canada, H3A 0C5"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7687-6629","authenticated-orcid":true,"given":"Karl J.","family":"Jobst","sequence":"additional","affiliation":[{"name":"Memorial University of Newfoundland , , , ,","place":["St. John\u2019s, NL, Canada, A1C 5S7"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Giovenazzo","sequence":"additional","affiliation":[{"name":"Universite\u0301 Laval , , , ,","place":["Que\u0301bec, QC, Canada, G1 V 0A6"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4552-4903","authenticated-orcid":true,"given":"Pedro A.","family":"Segura","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Sherbrooke , , , ,","place":["Sherbrooke, QC, Canada, J1K 2R1"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"3","key":"2026091609083879700_cit1","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1051\/apido\/2010018","article-title":"Pesticides and honey\nbee toxicity\u2013USA","volume":"41","author":"Johnson","year":"2010","journal-title":"Apidologie"},{"issue":"3","key":"2026091609083879700_cit2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1051\/apido\/2010013","article-title":"Coordinated\nresponses to honey bee decline in the USA","volume":"41","author":"Pettis","year":"2010","journal-title":"Apidologie"},{"issue":"1","key":"2026091609083879700_cit3","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3896\/IBRA.1.49.1.30","article-title":"Colony losses, managed colony population\ndecline, and Colony Collapse Disorder in the United States","volume":"49","author":"Ellis","year":"2010","journal-title":"J. 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