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Several compounds exhibited 100% inhibition against Sclerotinia sclerotiorum and Phytophthora capsici (Pc). Among them, Q8 showed the most potent activity against Pc with an EC50 value of 4.1 \u03bcg mL\u20131, superior to azoxystrobin (69.0 \u03bcg mL\u20131) and fluopyram (123.2 \u03bcg mL\u20131). In vivo tests on chili fruits demonstrated that Q8 at 200 \u03bcg mL\u20131 provided superior curative and protective effects (73.7 and 80.8%) compared to azoxystrobin (53.0 and 54.4%). Mechanistic studies revealed that Q8 disrupted cell membrane integrity and inhibited succinate dehydrogenase (SDH) activity, with computational simulations suggesting a higher binding affinity for SDH than fluopyram. Safety evaluation showed no obvious adverse effects on seed germination or earthworm survival. Collectively, these results indicate that Q8 represents a promising lead compound for fungicide development.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05505","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:02:34Z","timestamp":1786647754000},"page":"26006-26016","source":"Crossref","is-referenced-by-count":1,"title":["Novel Flavonol\nDerivatives Bearing a 1,2,3,4-Tetrahydroquinoline\nMoiety: Design, Synthesis, and Anti-\n                    <i>Phytophthora capsici<\/i>\n                    Activity"],"prefix":"10.1021","volume":"74","author":[{"given":"Qingxue","family":"Hu","sequence":"first","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Geng","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tian","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Pan","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-8411","authenticated-orcid":true,"given":"Gefei","family":"Hao","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2210-3831","authenticated-orcid":true,"given":"Linhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-1808","authenticated-orcid":true,"given":"Buddhi","family":"Marambe","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, University of Peradeniya , , ,","place":["Peradeniya, Sri Lanka, 20400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barana C.","family":"Jayawardana","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, University of Peradeniya , , ,","place":["Peradeniya, Sri Lanka, 20400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-5414","authenticated-orcid":true,"given":"Wei","family":"Xue","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"11","key":"2026090104471877200_cit1","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.3390\/genes16111263","article-title":"The Enhancement of Fungal Disease Resistance in Major\nStaple Crops Using CRISPR-Cas Technology","volume":"16","author":"Sapakhova","year":"2025","journal-title":"Genes"},{"issue":"2","key":"2026090104471877200_cit2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s42161-018-0069-z","article-title":"A Reappraisal\nof the Natural and Experimental Host Range of Neotropical Phytophthora\nCapsici Isolates from Solanaceae, Cucurbitaceae, Rosaceae, and Fabaceae","volume":"100","author":"Reis","year":"2018","journal-title":"J. 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