{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:24:16Z","timestamp":1787153056685,"version":"build-2736575974"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2026AFC0837"],"award-info":[{"award-number":["2026AFC0837"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260129"],"award-info":[{"award-number":["32260129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304892"],"award-info":[{"award-number":["82304892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Natural polysaccharides derived from Zingiber officinale (ZO) can alleviate ulcerative colitis (UC). In this study, a homogeneous glucan, ZOP-1a (250.39 kDa), was isolated from ZO and structurally characterized. ZOP-1a possessed an \u03b1-1,4-d-Glcp backbone, with branches substituted at H-6 by \u03b1-d-Glcp-(1 \u2192 6)-\u03b1-d-Glcp-(1\u2192 and at H-3 by \u03b1-d-Glcp-(1 \u2192 3)-\u03b2-d-Glcp-(1\u2192 and \u03b1-d-Glcpp-(1\u2192 residues. In DSS-induced colitis mice, ZOP-1a markedly ameliorated colon injury, as reflected by improved body weight, colon length, and histopathological damage, inhibited NF-\u03baB\/MAPK signaling and reshaped gut microbiota dysbiosis, thereby restoring intestinal homeostasis. Moreover, ZOP-1a increased the abundance of short-chain fatty acid (SCFA)-producing bacteria, and in vitro Lactobacillus fermentation supported its potential contribution to SCFA generation. Fecal microbiota transplantation from ZOP-1a-treated colitis mice effectively alleviated UC symptoms in recipient mice. Overall, ZOP-1a may serve as a promising prebiotic candidate for maintaining intestinal homeostasis and preventing UC.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05577","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:02:54Z","timestamp":1785945774000},"page":"25315-25334","source":"Crossref","is-referenced-by-count":0,"title":["Structural Characterization\nof a Glucan from\n                    <i>Zingiber officinale<\/i>\n                    and Its Efficacy in Alleviating\nUlcerative Colitis by Ameliorating Gut Microbiota Imbalance"],"prefix":"10.1021","volume":"74","author":[{"given":"Qiqi","family":"Wang","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Dongguan, China, 523000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinan University , , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Dongguan, China, 523000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"He","sequence":"additional","affiliation":[{"name":"Jinan University , , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Dongguan, China, 523000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-1683","authenticated-orcid":true,"given":"Denglang","family":"Zou","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Dongguan, China, 523000"]},{"name":"Jinan University , , ,","place":["Guangzhou, China, 510632"]},{"name":"Hubei University of Chinese Medicine , , ,","place":["Wuhan, China, 430065"]},{"name":"Hubei University of Chinese Medicine , , ,","place":["Wuhan, China, 430065"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"10432","key":"2026081910194271700_cit1","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/S0140-6736(23)02586-2","article-title":"Crohn\u2019s disease","volume":"403","author":"Dolinger","year":"2024","journal-title":"Lancet"},{"issue":"10218","key":"2026081910194271700_cit2","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0140-6736(19)33225-8","article-title":"Are patients with ulcerative colitis\nstill at increased\nrisk of colon cancer?","volume":"395","author":"Damas","year":"2020","journal-title":"Lancet"},{"issue":"22","key":"2026081910194271700_cit3","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1001\/jama.2019.3946","article-title":"Fecal microbiota\ntransplantation\nfor ulcerative colitis","volume":"321","author":"Benech","year":"2019","journal-title":"Jama"},{"key":"2026081910194271700_cit4","doi-asserted-by":"publisher","first-page":"122829","DOI":"10.1016\/j.carbpol.2024.122829","article-title":"Astragalus polysaccharides alleviate DSS-induced ulcerative colitis in mice\nby restoring SCFA production and regulating Th17\/Treg cell homeostasis\nin a microbiota-dependent manner","volume":"349","author":"Zhang","year":"2025","journal-title":"Carbohydr.\nPolym."},{"issue":"1","key":"2026081910194271700_cit5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1053\/j.scrs.2017.09.007","article-title":"March. Probiotics\nand fecal microbiota transplantation\nin surgical disorders","volume":"29","author":"Yeh","year":"2018","journal-title":"Semin. Colon. Rectal.\nS."},{"key":"2026081910194271700_cit6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.carbpol.2017.12.009","article-title":"Biological activities\nand pharmaceutical applications of polysaccharide from natural resources:\nA review","volume":"183","author":"Yu","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit7","doi-asserted-by":"publisher","first-page":"126799","DOI":"10.1016\/j.ijbiomac.2023.126799","article-title":"Research progress of natural plant\npolysaccharides inhibiting inflammatory\nsignaling pathways and regulating intestinal flora and metabolism\nto protect inflammatory bowel disease","volume":"253","author":"Zhang","year":"2023","journal-title":"Int.\nJ. Biol. Macromol."},{"key":"2026081910194271700_cit8","doi-asserted-by":"publisher","first-page":"138855","DOI":"10.1016\/j.ijbiomac.2024.138855","article-title":"Multifaceted\nroles of plant-derived bioactive polysaccharides:\nA review of their biological functions, delivery, bioavailability,\nand applications within the food and pharmaceutical sectors","volume":"290","author":"Salehi","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit9","doi-asserted-by":"publisher","first-page":"128887","DOI":"10.1016\/j.ijbiomac.2023.128887","article-title":"Regulation\nof the intestinal flora\nusing polysaccharides from Callicarpa nudiflora Hook\nto alleviate ulcerative colitis and the molecular mechanisms involved","volume":"258","author":"Qin","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit10","doi-asserted-by":"publisher","first-page":"130822","DOI":"10.1016\/j.ijbiomac.2024.130822","article-title":"Ginseng polysaccharides ameliorate\nulcerative colitis via regulating gut microbiota\nand tryptophan metabolism","volume":"265","author":"Wan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit11","doi-asserted-by":"crossref","DOI":"10.26599\/FMH.2024.9420018","article-title":"Perspectives in\nFood & Medicine Homology","volume-title":"Food & Medicine\nHomology","author":"Cong","year":"2024"},{"issue":"9","key":"2026081910194271700_cit12","doi-asserted-by":"publisher","first-page":"3901","DOI":"10.1016\/j.apsb.2024.06.002","article-title":"Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier\nto alleviate intestinal\ninflammation by modulating Akkermansia muciniphila abundance","volume":"14","author":"Wang","year":"2024","journal-title":"Acta. Pharm. Sinica. B"},{"key":"2026081910194271700_cit13","doi-asserted-by":"crossref","DOI":"10.1016\/j.nutos.2025.02.008","article-title":"Ginger\u2019s\nNutritional Implication on Gastrointestinal Health","volume-title":"Clinical Nutrition Open Science","author":"Aregawi","year":"2025"},{"key":"2026081910194271700_cit14","doi-asserted-by":"publisher","first-page":"116087","DOI":"10.1016\/j.foodres.2025.116087","article-title":"Probiotic-fermented ginger-processed Gastrodia elata BI. Ameliorates\nAlCl3-induced cognitive dysfunction in an Alzheimer\u2019s\ndisease rat model by regulating the gut microbiota and CREB\/BDNF pathway","volume":"207","author":"Huang","year":"2025","journal-title":"Food Res. Int."},{"issue":"1","key":"2026081910194271700_cit15","first-page":"1663","article-title":"Evaluation of phytochemical\nand nutritional composition\nof ginger rhizome powder","volume":"17","author":"Princewill","year":"2014","journal-title":"J. Agric. Rural Dev."},{"issue":"1","key":"2026081910194271700_cit16","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1038\/s41467-025-56624-0","article-title":"An abundant\nginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"2026081910194271700_cit17","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.ijbiomac.2022.11.104","article-title":"Ginger polysaccharides\nenhance intestinal immunity\nby modulating gut microbiota in cyclophosphamide-induced immunosuppressed\nmice","volume":"223","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"2026081910194271700_cit18","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3390\/foods8060185","article-title":"Bioactive\ncompounds and bioactivities\nof ginger (Zingiber officinale Roscoe)","volume":"8","author":"Mao","year":"2019","journal-title":"Foods"},{"issue":"24","key":"2026081910194271700_cit19","doi-asserted-by":"publisher","first-page":"10651","DOI":"10.1039\/D3FO03552B","article-title":"Research\nprogress on ginger polysaccharides: extraction, purification and structure\u2013bioactivity\nrelationship","volume":"14","author":"Wu","year":"2023","journal-title":"Food Funct."},{"key":"2026081910194271700_cit20","doi-asserted-by":"publisher","first-page":"117912","DOI":"10.1016\/j.lwt.2025.117912","article-title":"Simultaneous extraction of crude\npolysaccharides, soluble proteins, gingerols, and shogaols from dried\nginger by subcritical water extraction","volume":"225","author":"Sakdasri","year":"2025","journal-title":"LWT"},{"key":"2026081910194271700_cit21","doi-asserted-by":"publisher","first-page":"136474","DOI":"10.1016\/j.ijbiomac.2024.136474","article-title":"Physicochemical properties, structure\nand biological\nactivity of ginger polysaccharide: Effect of microwave infrared dual-field\ncoupled drying","volume":"281","author":"Zeng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit22","doi-asserted-by":"publisher","first-page":"129833","DOI":"10.1016\/j.ijbiomac.2024.129833","article-title":"Effect of subcritical water temperature\non the chain\nconformation and immune activity of ginger polysaccharides","volume":"261","author":"Zheng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit23","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.ijbiomac.2022.08.032","article-title":"Ginger\npolysaccharides\nrelieve ulcerative colitis via maintaining intestinal\nbarrier integrity and gut microbiota modulation","volume":"219","author":"Hao","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"2026081910194271700_cit24","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3390\/foods14050753","article-title":"Structure\ncharacterization and treatment\neffect of zingiber officinale polysaccharide on dextran\nsulfate sodium-induced ulcerative colitis","volume":"14","author":"Jing","year":"2025","journal-title":"Foods"},{"key":"2026081910194271700_cit25","doi-asserted-by":"publisher","first-page":"137621","DOI":"10.1016\/j.ijbiomac.2024.137621","article-title":"Structural characterization\nand anti-fatigue mechanism based on the gut-muscle axis of a polysaccharide\nfrom Zingiber officinale","volume":"283","author":"Jing","year":"2024","journal-title":"Int.\nJ. Biol. Macromol."},{"key":"2026081910194271700_cit26","doi-asserted-by":"publisher","first-page":"121709","DOI":"10.1016\/j.carbpol.2023.121709","article-title":"Structural\ncharacterization and osteogenic differentiation-promoting activity\nof polysaccharide purified from Chroogomphus rutilus","volume":"328","author":"Zhou","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit27","doi-asserted-by":"publisher","first-page":"123386","DOI":"10.1016\/j.ijbiomac.2023.123386","article-title":"Structure\nof a Pueraria root polysaccharide and its immunoregulatory activity\non T and B lymphocytes, macrophages, and immunosuppressive mice","volume":"230","author":"Cai","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit28","doi-asserted-by":"publisher","first-page":"121669","DOI":"10.1016\/j.carbpol.2023.121669","article-title":"Structural characteristics of steamed Polygonatum cyrtonema polysaccharide and its bioactivity on colitis via\nimproving the intestinal barrier and modifying the gut microbiota","volume":"327","author":"Gong","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit29","doi-asserted-by":"publisher","first-page":"120441","DOI":"10.1016\/j.carbpol.2022.120441","article-title":"Structural characterization\nand anti-inflammatory effects of an arabinan isolated from Rehmannia glutinosa Libosch","volume":"303","author":"Zhang","year":"2023","journal-title":"Carbohydr.\nPolym."},{"key":"2026081910194271700_cit30","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.ijbiomac.2019.01.214","article-title":"Extraction,\npurification and properties of water-soluble polysaccharides from\nmushroom Lepista nuda","volume":"128","author":"Shu","year":"2019","journal-title":"Int.\nJ. Biol. Macromol."},{"key":"2026081910194271700_cit31","doi-asserted-by":"publisher","first-page":"121565","DOI":"10.1016\/j.carbpol.2023.121565","article-title":"Structural\nelucidation of an active\npolysaccharide from Radix Puerariae lobatae and its\nprotection against acute alcoholic liver disease","volume":"325","author":"Cao","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit32","doi-asserted-by":"publisher","first-page":"120453","DOI":"10.1016\/j.carbpol.2022.120453","article-title":"Structure and hepatoprotective\nactivity of Usp10\/NF-\u03baB\/Nrf2 pathway-related Morchella esculenta polysaccharide","volume":"303","author":"Teng","year":"2023","journal-title":"Carbohydr.\nPolym."},{"key":"2026081910194271700_cit33","doi-asserted-by":"publisher","first-page":"123838","DOI":"10.1016\/j.carbpol.2025.123838","article-title":"Structural feature\nand antitumor activity of a N-acetylglucosamine\ncontaining polysaccharide from Ganoderma sinense","volume":"366","author":"Feng","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit34","doi-asserted-by":"publisher","first-page":"119718","DOI":"10.1016\/j.carbpol.2022.119718","article-title":"Structure elucidation\nand antitumor activity of a water soluble polysaccharide from Hemicentrotus pulcherrimus","volume":"292","author":"Jiang","year":"2022","journal-title":"Carbohydr.\nPolym."},{"key":"2026081910194271700_cit35","doi-asserted-by":"publisher","first-page":"125124","DOI":"10.1016\/j.ijbiomac.2023.125124","article-title":"Structural\ncharacterization and in vitro hepatoprotective activity\nof a novel antioxidant polysaccharide\nfrom fruiting bodies of the mushroom Pleurotus ferulae","volume":"243","author":"Muhaxi","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit36","doi-asserted-by":"publisher","first-page":"121613","DOI":"10.1016\/j.carbpol.2023.121613","article-title":"Yucca schidigera\npurpurea-sourced arabinogalactan polysaccharides\naugments antioxidant capacity facilitating intestinal antioxidant\nfunctions","volume":"326","author":"Fan","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit37","doi-asserted-by":"publisher","first-page":"121747","DOI":"10.1016\/j.carbpol.2023.121747","article-title":"Effect of chemical, thermal, and enzymatic processing\nof wheat bran on the solubilization, technological and biological\nproperties of non-starch polysaccharides","volume":"328","author":"Paesani","year":"2024","journal-title":"Carbohydr.\nPolym."},{"key":"2026081910194271700_cit38","doi-asserted-by":"publisher","first-page":"123634","DOI":"10.1016\/j.carbpol.2025.123634","article-title":"Nanoporous\ncarboxymethyl cellulose\naerogels with enhanced thermal insulation and mechanical toughness","volume":"361","author":"Yang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit39","doi-asserted-by":"publisher","first-page":"123710","DOI":"10.1016\/j.carbpol.2025.123710","article-title":"Pectin-type polysaccharides from\nraspberry (Rubus idaeus L.): structure characterization\nand activity\nagainst DSS-induced colitis","volume":"364","author":"Dou","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit40","doi-asserted-by":"publisher","first-page":"155122","DOI":"10.1016\/j.prp.2024.155122","article-title":"Targeting\nMAPK signaling: a promising approach for treating inflammatory lung\ndisease","volume":"254","author":"Saleem","year":"2024","journal-title":"Pathol. Res."},{"key":"2026081910194271700_cit41","doi-asserted-by":"publisher","first-page":"1721584","DOI":"10.3389\/fphar.2025.1721584","article-title":"Natural products targeting the MAPK signaling pathway:\npotential options for ulcerative colitis treatment","volume":"16","author":"Li","year":"2026","journal-title":"Front. Pharmacol."},{"key":"2026081910194271700_cit42","doi-asserted-by":"publisher","first-page":"859167","DOI":"10.3389\/fphar.2022.859167","article-title":"Wu-mei-wan ameliorates\nmurine ulcerative colitis by regulating macrophage polarization","volume":"13","author":"Yan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"2026081910194271700_cit43","doi-asserted-by":"publisher","first-page":"106794","DOI":"10.1016\/j.intimp.2020.106794","article-title":"Anemoside B4 prevents\nacute ulcerative colitis through inhibiting\nof TLR4\/NF-\u03baB\/MAPK signaling pathway","volume":"87","author":"Ma","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"2026081910194271700_cit44","doi-asserted-by":"publisher","first-page":"111321","DOI":"10.1016\/j.fct.2020.111321","article-title":"Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages\nmodel and intestinal-like Caco-2\/macrophages co-culture inflammation\nmodel","volume":"140","author":"Hu","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"2026081910194271700_cit45","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.ijbiomac.2019.02.088","article-title":"Anti-inflammatory\neffects of Morchella esculenta polysaccharide and\nits derivatives in fine particulate matter-treated NR8383 cells","volume":"129","author":"Li","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit46","doi-asserted-by":"publisher","first-page":"156490","DOI":"10.1016\/j.phymed.2025.156490","article-title":"Sea buckthorn berries\nalleviate ulcerative colitis via regulating gut Faecalibaculum rodentium-mediated\nbutyrate biosynthesis","volume":"139","author":"Song","year":"2025","journal-title":"Phytomedicine"},{"key":"2026081910194271700_cit47","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.ijbiomac.2018.01.087","article-title":"Structural characterization and antioxidant\nactivity of polysaccharide\nfrom ginger","volume":"111","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit48","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.ijbiomac.2020.02.325","article-title":"Characterization\nand antitumor activities of polysaccharides\nobtained from ginger (Zingiber officinale) by different\nextraction methods","volume":"152","author":"Liao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit49","doi-asserted-by":"publisher","first-page":"129261","DOI":"10.1016\/j.foodchem.2021.129261","article-title":"A neutral polysaccharide\nwith a triple helix structure from ginger: Characterization and immunomodulatory\nactivity","volume":"350","author":"Yang","year":"2021","journal-title":"Food Chem."},{"issue":"39","key":"2026081910194271700_cit50","doi-asserted-by":"publisher","first-page":"24688","DOI":"10.1021\/acs.jafc.5c05665","article-title":"Characterization of Ginger Polysaccharide and Amelioration\nof High-Fat-Induced Obesity by Regulating the Energy Intake and Expenditure","volume":"73","author":"Liang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"2026081910194271700_cit51","doi-asserted-by":"publisher","first-page":"133711","DOI":"10.1016\/j.ijbiomac.2024.133711","article-title":"Effects of dietary ginger (Zingiber officinale) polysaccharide on the growth, antioxidant, immunity response, intestinal\nmicrobiota, and disease resistance to Aeromonas hydrophila in crucian\ncarp (Carassius auratus)","volume":"275","author":"Luo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit52","doi-asserted-by":"publisher","first-page":"119131","DOI":"10.1016\/j.jep.2024.119131","article-title":"Exploring\nthe structure-activity\nrelationship of safflower polysaccharides: From the structural characteristics\nto biological function and therapeutic applications","volume":"339","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"2026081910194271700_cit53","doi-asserted-by":"publisher","first-page":"117863","DOI":"10.1016\/j.carbpol.2021.117863","article-title":"Extraction,\npurification,\nstructural characteristics and biological properties of the polysaccharides\nfrom Codonopsis pilosula: A review","volume":"261","author":"Luan","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit54","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.ijbiomac.2019.01.159","article-title":"Isolation, purification,\nstructural analysis and biological activities of water-soluble polysaccharide\nfrom glehniae radix","volume":"128","author":"Du","year":"2019","journal-title":"Int. J.\nBiol. Macromol."},{"key":"2026081910194271700_cit55","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.ijbiomac.2020.04.201","article-title":"Effects of polysaccharide from Pueraria lobata on\ngut microbiota in mice","volume":"158","author":"Chen","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit56","doi-asserted-by":"publisher","first-page":"138359","DOI":"10.1016\/j.ijbiomac.2024.138359","article-title":"Fructans with various\nmolecular weights from Polygonatum cyrtonema Hua\ndifferentially ameliorate intestinal inflammation by regulating the\ngut microbiota and maintaining intestinal barrier","volume":"285","author":"Yuan","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit57","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1016\/j.ijbiomac.2021.11.024","article-title":"Effects of molecular\nweight of chitosan on anti-inflammatory activity and modulation of\nintestinal microflora in an ulcerative colitis model","volume":"193","author":"Niu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit58","doi-asserted-by":"publisher","first-page":"129067","DOI":"10.1016\/j.ijbiomac.2023.129067","article-title":"The molecular\nmechanism of polysaccharides in combating major depressive disorder:\nA comprehensive review","volume":"259","author":"Kong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081910194271700_cit59","doi-asserted-by":"publisher","first-page":"122527","DOI":"10.1016\/j.carbpol.2024.122527","article-title":"A novel antidepressant\nhomogeneous polysaccharide YLP-1\nfrom Millettia pulchra ameliorates tryptophan metabolism\nand SCFAs through modulating gut microbiota","volume":"344","author":"Yu","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"2026081910194271700_cit60","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1021\/acs.biomac.9b01644","article-title":"Recent advances\nin chain conformation and bioactivities of triple-helix polysacchar\nides","volume":"21","author":"Meng","year":"2020","journal-title":"Biomacromolecules"},{"issue":"1","key":"2026081910194271700_cit61","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/19490976.2016.1270810","article-title":"Dysbiosis in Crohn\u2019s disease-joint\naction of\nstochastic injuries and focal inflammation in the gut","volume":"8","author":"Butto\u0301","year":"2017","journal-title":"Gut Microbes"},{"issue":"6","key":"2026081910194271700_cit62","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01651-22","article-title":"Probiotics (Lactobacillus plantarum\nHNU082) supplementation relieves ulcerative colitis by affecting intestinal\nbarrier functions, immunity-related gene expression, gut microbiota,\nand metabolic pathways in mice","volume":"10","author":"Wu","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"2026081910194271700_cit63","doi-asserted-by":"publisher","first-page":"125919","DOI":"10.1016\/j.ijbiomac.2023.125919","article-title":"Therapeutic efficacy\nand underlying mechanisms of Gastrodia elata polysaccharides\non dextran sulfate sodium-induced\ninflammatory bowel disease in mice: Modulation of the gut microbiota\nand improvement of metabolic disorders","volume":"248","author":"Xu","year":"2023","journal-title":"Int.\nJ. Biol. Macromol."},{"issue":"1","key":"2026081910194271700_cit64","doi-asserted-by":"publisher","first-page":"8878633","DOI":"10.1155\/2021\/8878633","article-title":"Protective role\nof a new polysaccharide extracted from Lonicera japonica Thunb in mice with ulcerative colitis\ninduced by dextran sulphate sodium","volume":"2021","author":"Zhou","year":"2021","journal-title":"BioMed Res.\nInt."},{"issue":"3","key":"2026081910194271700_cit65","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/ibd\/izx029","article-title":"A cross-talk between microbiota-derived\nshort-chain fatty acids and the host mucosal immune system regulates\nintestinal homeostasis and inflammatory bowel disease","volume":"24","author":"Gonc\u0327alves","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"issue":"36","key":"2026081910194271700_cit66","doi-asserted-by":"publisher","first-page":"11245","DOI":"10.1021\/acs.jafc.2c03091","article-title":"Study on the effect of molecular weight on the gut microbiota fermentation\nproperties of blackberry polysaccharides in vitro","volume":"70","author":"Li","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"14","key":"2026081910194271700_cit67","doi-asserted-by":"publisher","first-page":"6582","DOI":"10.1039\/D3FO01253K","article-title":"A polysaccharide from Allium tenuissimum L. flowers\nrelieves ulcerative colitis by regulating the inflammatory signaling\npathway and gut microbiota","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct."},{"key":"2026081910194271700_cit68","doi-asserted-by":"publisher","first-page":"113709","DOI":"10.1016\/j.lwt.2022.113709","article-title":"The effect of fermentation conditions\n(temperature, salt concentration, and pH) with lactobacillus strains\nfor producing short chain fatty acids","volume":"165","author":"Hadinia","year":"2022","journal-title":"LWT"},{"key":"2026081910194271700_cit69","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain\nfatty acids (SCFAs)-mediated gut epithelial and immune regulation\nand its relevance for inflammatory bowel diseases","volume":"10","author":"Venegas","year":"2019","journal-title":"Front. Immunol."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c05577","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/32\/25315\/66415603\/acs.jafc.6c05577.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/32\/25315\/66415603\/acs.jafc.6c05577.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:25:59Z","timestamp":1787149559000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/32\/25315\/5246212\/Structural-Characterization-of-a-Glucan-from"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":69,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,8,5]]},"published-print":{"date-parts":[[2026,8,19]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c05577","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]}}}