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Based on the differences in solubility, two components were obtained: supernatant polysaccharides from gluconic acid hydrolysis of APCP (s-GA-PCP, 61.5%) and precipitate polysaccharides from gluconic acid hydrolysis of APCP (p-GA-PCP, 38.5%). In a DSS-induced chronic colitis mouse model, both alleviated symptoms (weight\/colon length recovery), restored the intestinal barrier (upregulated ZO-1\/Occludin), and reduced serum TNF-\u03b1. p-GA-PCP showed better effects, while the MIX group (1:1 mixture) did not show improved efficacy compared with the p-GA-PCP alone group. Both regulated gut microbiota (enriched Lactobacillus and Bifidobacterium; reduced Bacteroidota and Verrucomicrobiota) and altered metabolic profiles. p-GA-PCP specifically enriched maslinic acid, isocitric acid, and oxoglutaric acid. Correlation analysis and in vitro experiments suggest Bifidobacterium metabolizes p-GA-PCP to produce these beneficial metabolites, exerting anti-inflammatory effects.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05795","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:20:24Z","timestamp":1785849624000},"page":"24394-24406","source":"Crossref","is-referenced-by-count":1,"title":["Gluconic Acid-Induced\nSolubilization and Anticolitis\nAction of Alkali-Soluble\n                    <i>Poria cocos<\/i>\n                    Polysaccharide Derivatives"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0300-0676","authenticated-orcid":true,"given":"Fenfa","family":"Li","sequence":"first","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Sun","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-6902","authenticated-orcid":true,"given":"Jianming","family":"Luo","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-5203","authenticated-orcid":true,"given":"Xichun","family":"Peng","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"2026081208093844900_cit1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/bs.pmbts.2019.02.011","article-title":"Molecular basis for Poria cocos mushroom polysaccharide\nused as an antitumor drug in China","volume":"163","author":"Li","year":"2019","journal-title":"Prog. 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