{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:22Z","timestamp":1792784662327,"version":"4.5.0"},"reference-count":87,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100020749","name":"Hubei Key Laboratory of Wudang Local Chinese Medicine Research","doi-asserted-by":"publisher","award":["WDCM2024001"],"award-info":[{"award-number":["WDCM2024001"]}],"id":[{"id":"10.13039\/501100020749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2026AFC0949"],"award-info":[{"award-number":["2026AFC0949"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505088"],"award-info":[{"award-number":["82505088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Provincial Key Laboratory of Traditional Chinese Medicine Resources and Chinese Medicine Chemistry, Hubei University of Chinese Medicine","award":["KLRCCM2501"],"award-info":[{"award-number":["KLRCCM2501"]}],"id":[{"id":"https:\/\/ror.org\/02my3bx32","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University","award":["2024ZLKF2-54"],"award-info":[{"award-number":["2024ZLKF2-54"]}],"id":[{"id":"https:\/\/ror.org\/0419nfc77","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic kidney disease (CKD) is a serious public health challenge that closely correlates with unhealthy diets. Gigantol, a naturally active compound derived from the edible plant Dendrobium, has shown potential in renal protection, but its efficacy in treating metabolic dysfunction-related CKD driven by a high-fat and high-fructose diet (HFFD) remains unclear. Here, we found that gigantol restored abnormal renal function and pathological manifestations in HFFD-fed mice. Mechanistically, gigantol suppresses the phosphorylation of TFEB at Ser211 and promotes TFEB nuclear translocation to enhance PINK1\/Parkin-mediated mitophagy and suppress ferroptosis. Similar findings were observed in palmitic-acid-induced cell models. Notably, silencing TFEB or blocking mitophagy reversed the effect of gigantol on suppressing ferroptosis and improving renal injury. Overall, this study demonstrates that gigantol alleviates metabolic-dysfunction-related CKD in mice by promoting TFEB-mediated mitophagy to suppress ferroptosis, suggesting that dietary supplementation with Dendrobium or gigantol represents an effective strategy in mitigating CKD, especially subtypes driven by metabolic dysfunction.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05807","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:03:54Z","timestamp":1790712234000},"page":"31630-31646","source":"Crossref","is-referenced-by-count":0,"title":["Gigantol Ameliorates\nHigh-Fat and High-Fructose Diet-Induced\nChronic Kidney Disease by Promoting TFEB-Mediated Mitophagy to Suppress\nFerroptosis"],"prefix":"10.1021","volume":"74","author":[{"given":"Yingying","family":"Song","sequence":"first","affiliation":[{"name":"Hubei University of Chinese Medicine , , ,","place":["Wuhan, China, 430065"]},{"name":"Hubei University of Chinese Medicine , , ,","place":["Wuhan, China, 430065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurou","family":"Huang","sequence":"additional","affiliation":[{"name":"Hubei University of Chinese Medicine , , ,","place":["Wuhan, China, 430065"]},{"name":"Hubei University of Chinese Medicine , , ,","place":["Wuhan, China, 430065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Huang","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , ,","place":["Yichang, China, 443002"]},{"name":"China Three Gorges University , , ,","place":["Yichang, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxi","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Medical Technology, Peking University Health Science Center , ,","place":["Beijing, China, 1001913"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , ,","place":["Yichang, China, 443002"]},{"name":"China Three Gorges University , , ,","place":["Yichang, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwu","family":"Qin","sequence":"additional","affiliation":[{"name":"Third People\u2019s Hospital of China Three Gorges University , , ,","place":["Yichang, China, 443099"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Medical Technology, Peking University Health Science Center , ,","place":["Beijing, China, 1001913"]},{"name":"Three Gorges University Hospital of Traditional Chinese Medicine & Yichang Hospital of Traditional Chinese Medicine , ,","place":["Yichang, China, 443008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2443-2361","authenticated-orcid":true,"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , ,","place":["Yichang, China, 443002"]},{"name":"China Three Gorges University , , ,","place":["Yichang, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"23","key":"2026101408094342600_cit1","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1093\/eurheartj\/ehaf167","article-title":"Cardiovascular disease in chronic\nkidney disease","volume":"46","author":"Marx-Schutt","year":"2025","journal-title":"Eur. Heart J."},{"issue":"10518","key":"2026101408094342600_cit2","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/S0140-6736(25)01853-7","article-title":"Global, regional, and national burden\nof chronic kidney disease in adults, 1990\u20132023, and its attributable\nrisk factors: a systematic analysis for the Global Burden of Disease\nStudy 2023","volume":"406","author":"GBD 2023 Chronic Kidney Disease Collaborators","year":"2025","journal-title":"Lancet"},{"issue":"10523","key":"2026101408094342600_cit3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/S0140-6736(25)01942-7","article-title":"Chronic kidney disease","volume":"407","author":"Herrington","year":"2026","journal-title":"Lancet"},{"issue":"10513","key":"2026101408094342600_cit4","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0140-6736(25)01917-8","article-title":"Global burden of 292 causes of death in 204\ncountries and territories and 660 subnational locations, 1990\u20132023:\na systematic analysis for the Global Burden of Disease Study 2023","volume":"406","author":"GBD 2023 Causes of Death Collaborators","year":"2025","journal-title":"Lancet"},{"issue":"1","key":"2026101408094342600_cit5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41581-024-00889-z","article-title":"Metabolism at the crossroads of inflammation\nand fibrosis in chronic kidney disease","volume":"21","author":"Miguel","year":"2025","journal-title":"Nat.\nRev. Nephrol."},{"issue":"2","key":"2026101408094342600_cit6","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.ekir.2024.10.035","article-title":"The Role of\nMitochondria in Diabetic Kidney Disease\nand Potential Therapeutic Targets","volume":"10","author":"Takasu","year":"2025","journal-title":"Kidney Int.\nRep."},{"issue":"2","key":"2026101408094342600_cit7","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202216581","article-title":"LONP1 targets HMGCS2 to protect mitochondrial function\nand attenuate chronic kidney disease","volume":"15","author":"Bai","year":"2023","journal-title":"EMBO Mol.\nMed."},{"issue":"6","key":"2026101408094342600_cit8","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.kint.2025.01.022","article-title":"Mitochondrial\ndysfunction and mitophagy\nblockade contribute to renal osteodystrophy in chronic kidney disease-mineral\nbone disorder","volume":"107","author":"Hsu","year":"2025","journal-title":"Kidney Int."},{"issue":"3","key":"2026101408094342600_cit9","doi-asserted-by":"publisher","first-page":"937","DOI":"10.7150\/ijbs.89916","article-title":"Loss of MTX2\ncauses mitochondrial dysfunction, podocyte injury, nephrotic proteinuria\nand glomerulopathy in mice and patients","volume":"20","author":"Li","year":"2024","journal-title":"Int.\nJ. Biol. Sci."},{"issue":"4","key":"2026101408094342600_cit10","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.cmet.2019.08.003","article-title":"Mitochondrial Damage and Activation\nof the STING Pathway Lead to Renal Inflammation and Fibrosis","volume":"30","author":"Chung","year":"2019","journal-title":"Cell Metab."},{"key":"2026101408094342600_cit11","doi-asserted-by":"publisher","first-page":"102860","DOI":"10.1016\/j.redox.2023.102860","article-title":"LRRK2 aggravates\nkidney injury through promoting MFN2 degradation and abnormal mitochondrial\nintegrity","volume":"66","author":"Zhang","year":"2023","journal-title":"Redox Biol."},{"key":"2026101408094342600_cit12","doi-asserted-by":"publisher","first-page":"116669","DOI":"10.1016\/j.bcp.2024.116669","article-title":"Mitochondria-targeting therapeutic\nstrategies for chronic kidney disease","volume":"231","author":"Sun","year":"2025","journal-title":"Biochem.\nPharmacol."},{"issue":"3","key":"2026101408094342600_cit13","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1080\/15548627.2023.2259282","article-title":"FGF21 and autophagy\ncoordinately counteract kidney disease progression\nduring aging and obesity","volume":"20","author":"Minami","year":"2024","journal-title":"Autophagy"},{"issue":"4","key":"2026101408094342600_cit14","doi-asserted-by":"publisher","first-page":"503","DOI":"10.4093\/dmj.2023.0213","article-title":"Dysfunctional Mitochondria Clearance\nin Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic\nDiseases","volume":"48","author":"Tang","year":"2024","journal-title":"Diabetes Metab J."},{"issue":"9","key":"2026101408094342600_cit15","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1021\/acs.jafc.1c07795","article-title":"Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic\nKidney Disease Mice through the Promotion of Mitophagy via the Nrf2\/PINK\/Parkin\nPathway","volume":"70","author":"Ding","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"2026101408094342600_cit16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/15548627.2025.2581214","article-title":"XIAP-ULK1-mediated\nmitophagy modulates carnitine metabolism to mitigate\ndiabetic kidney disease","volume":"22","author":"Hu","year":"2026","journal-title":"Autophagy"},{"issue":"4","key":"2026101408094342600_cit17","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1080\/15548627.2025.2601874","article-title":"ESRRA-ATG5-Mediated\nmitophagy enhances\narginine metabolism to alleviate diabetic kidney disease","volume":"22","author":"Hu","year":"2026","journal-title":"Autophagy"},{"issue":"22","key":"2026101408094342600_cit18","doi-asserted-by":"publisher","first-page":"12775","DOI":"10.1021\/acs.jafc.3c09634","article-title":"Magnoflorine\nAmeliorates\nChronic Kidney Disease in High-Fat and High-Fructose-Fed Mice by Promoting\nParkin\/PINK1-Dependent Mitophagy to Inhibit NLRP3\/Caspase-1-Mediated\nPyroptosis","volume":"72","author":"Cheng","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"2026101408094342600_cit19","doi-asserted-by":"publisher","first-page":"907209","DOI":"10.3389\/fphar.2022.907209","article-title":"Urolithin\nA Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing\nSTING-NLRP3 Axis-Mediated Inflammatory Response via Restoration of\nParkin-Dependent Mitophagy","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"2026101408094342600_cit20","doi-asserted-by":"publisher","first-page":"109201","DOI":"10.1016\/j.jdiacomp.2025.109201","article-title":"The role\nof oral alpha-lipoic acid as an adjuvant antioxidant therapy in diabetic\nnephropathy among children and adolescents with type 1 diabetes: a\nrandomized controlled trial","volume":"40","author":"Elhenawy","year":"2026","journal-title":"J. Diabetes Complicat."},{"issue":"10","key":"2026101408094342600_cit21","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1016\/j.ymthe.2023.07.026","article-title":"STING\/ACSL4\naxis-dependent ferroptosis\nand inflammation promote hypertension-associated chronic kidney disease","volume":"31","author":"Gao","year":"2023","journal-title":"Mol. Ther."},{"issue":"1","key":"2026101408094342600_cit22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41420-022-00931-8","article-title":"Ferroptosis,\na new target for treatment of renal injury and fibrosis in a 5\/6 nephrectomy-induced\nCKD rat model","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov."},{"issue":"1","key":"2026101408094342600_cit23","doi-asserted-by":"publisher","first-page":"114875","DOI":"10.1016\/j.yexcr.2025.114875","article-title":"MiR-181c-5p-SIRT1\naxis-driven Pink1\/Parkin-mediated mitophagy prevents ferroptosis and\nvascular calcification in chronic kidney disease","volume":"456","author":"Chen","year":"2026","journal-title":"Exp. Cell Res."},{"issue":"4","key":"2026101408094342600_cit24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10495-026-02267-5","article-title":"SIRT1-regulated\nmitophagy mitigates\nlipotoxicity-induced ferroptosis in diabetic kidney disease","volume":"31","author":"Jian","year":"2026","journal-title":"Apoptosis"},{"issue":"4","key":"2026101408094342600_cit25","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.7150\/ijbs.80775","article-title":"Mitophagy alleviates cisplatin-induced renal tubular\nepithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis","volume":"19","author":"Lin","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"10","key":"2026101408094342600_cit26","doi-asserted-by":"publisher","first-page":"101284","DOI":"10.1016\/j.jpha.2025.101284","article-title":"Metformin alleviates renal tubular\ninjury in diabetic kidney disease by activating mitophagy and inhibiting\nferroptosis via HIF-1alpha\/MIOX axis","volume":"15","author":"Wu","year":"2025","journal-title":"J. Pharm.\nAnal."},{"issue":"1","key":"2026101408094342600_cit27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12875-018-0783-9","article-title":"Expanding the role of clinical pharmacists\non interdisciplinary primary care teams for chronic pain and opioid\nmanagement","volume":"19","author":"Giannitrapani","year":"2018","journal-title":"BMC Fam. Pract."},{"issue":"12","key":"2026101408094342600_cit28","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1017\/S1368980021001828","article-title":"The impact of a produce\nprescription programme on healthy food purchasing and diabetes-related\nhealth outcomes","volume":"24","author":"Xie","year":"2021","journal-title":"Public Health Nutr."},{"issue":"3","key":"2026101408094342600_cit29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41581-020-00345-8","article-title":"Food as medicine:\ntargeting the uraemic phenotype in\nchronic kidney disease","volume":"17","author":"Mafra","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"2026101408094342600_cit30","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4062\/biomolther.2024.142","article-title":"Natural Compounds\nin Kidney Disease: Therapeutic Potential\nand Drug Development","volume":"33","author":"Natesan","year":"2025","journal-title":"Biomol. Ther."},{"issue":"11","key":"2026101408094342600_cit31","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1038\/s41401-020-0406-6","article-title":"Dihydro-stilbene\ngigantol relieves CCl(4)-induced hepatic\noxidative stress and inflammation in mice via inhibiting C5b-9 formation\nin the liver","volume":"41","author":"Xue","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"5","key":"2026101408094342600_cit32","doi-asserted-by":"publisher","first-page":"4389","DOI":"10.1021\/acs.jafc.5c09366","article-title":"Gigantol Ameliorates\nMetabolic Dysfunction-Associated Steatohepatitis\nby Promoting TFEB-Mediated Lipophagy and Fatty Acid Oxidation","volume":"74","author":"Zhang","year":"2026","journal-title":"J. Agric. Food Chem."},{"key":"2026101408094342600_cit33","doi-asserted-by":"publisher","first-page":"1474808","DOI":"10.3389\/fendo.2025.1474808","article-title":"Therapeutic\neffect and mechanism of gigantol on hyperuricemia","volume":"16","author":"Wu","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"1","key":"2026101408094342600_cit34","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3390\/molecules24010080","article-title":"Gigantol\nhas Protective Effects against High Glucose-Evoked Nephrotoxicity\nin Mouse Glomerulus Mesangial Cells by Suppressing ROS\/MAPK\/NF-kappaB\nSignaling Pathways","volume":"24","author":"Chen","year":"2019","journal-title":"Molecules"},{"issue":"2","key":"2026101408094342600_cit35","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.kint.2025.01.044","article-title":"Metabolic dysfunction-associated\nkidney disease: pathogenesis\nand clinical manifestations","volume":"108","author":"Bansal","year":"2025","journal-title":"Kidney Int."},{"issue":"10","key":"2026101408094342600_cit36","doi-asserted-by":"publisher","first-page":"6158","DOI":"10.1021\/acs.jafc.4c07684","article-title":"Morroniside Ameliorates\nHigh-Fat\nand High-Fructose-Driven Chronic Kidney Disease by Motivating AMPK-TFEB\nSignal Activation to Accelerate Lipophagy and Inhibiting Inflammatory\nResponse","volume":"73","author":"Zhang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"2026101408094342600_cit37","doi-asserted-by":"publisher","first-page":"108028","DOI":"10.1016\/j.phrs.2025.108028","article-title":"Mdivi-1 promotes\nlipid droplets-mitochondria contact and ameliorates cardiac lipotoxicity\nin high-fat diet-fed mice","volume":"222","author":"Xu","year":"2025","journal-title":"Pharmacol. Res."},{"key":"2026101408094342600_cit38","doi-asserted-by":"publisher","first-page":"112001","DOI":"10.1016\/j.intimp.2024.112001","article-title":"Inhibition\nof Drp1-mediated mitochondrial fission improves contrast-induced acute\nkidney injury by targeting the mROS-TXNIP-NLRP3 inflammasome axis","volume":"133","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"2026101408094342600_cit39","doi-asserted-by":"publisher","first-page":"00381-4","DOI":"10.1016\/j.jare.2026.05.006","article-title":"Renal tubular\nNfe2l1 protect cisplatin-induced acute kidney injury via suppressing\nACSL4-dependent ferroptosis","volume":"S2090-1232","author":"Hu","year":"2026","journal-title":"J. Adv. Res."},{"issue":"10","key":"2026101408094342600_cit40","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1080\/15548627.2022.2037920","article-title":"Assessment of mitophagy in human iPSC-derived cardiomyocytes","volume":"18","author":"Yang","year":"2022","journal-title":"Autophagy"},{"issue":"1","key":"2026101408094342600_cit41","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12933-025-03057-0","article-title":"Prognostic effect of triglyceride glucose-related parameters\non all-cause\nand cardiovascular mortality in individuals with cardiovascular-kidney-metabolic\nsyndrome: evidence from international multi-cohort studies","volume":"25","author":"Li","year":"2026","journal-title":"Cardiovasc. Diabetol."},{"issue":"2","key":"2026101408094342600_cit42","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41581-023-00775-0","article-title":"Oxidative\nstress and the role of redox signalling in chronic kidney disease","volume":"20","author":"Kishi","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"2026101408094342600_cit43","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41581-023-00694-0","article-title":"Regulated\ncell death\npathways in kidney disease","volume":"19","author":"Sanz","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"issue":"12","key":"2026101408094342600_cit44","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy\nin human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat. Metab."},{"key":"2026101408094342600_cit45","doi-asserted-by":"publisher","first-page":"103435","DOI":"10.1016\/j.redox.2024.103435","article-title":"YAP1 preserves\ntubular mitochondrial quality control to mitigate diabetic kidney\ndisease","volume":"78","author":"Ye","year":"2024","journal-title":"Redox Biol."},{"issue":"6","key":"2026101408094342600_cit46","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200199rr","article-title":"Mitophagy\ninduced by UMI-77 preserves mitochondrial fitness in renal tubular\nepithelial cells and alleviates renal fibrosis","volume":"36","author":"Jin","year":"2022","journal-title":"FASEB J."},{"issue":"5","key":"2026101408094342600_cit47","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.kint.2023.01.025","article-title":"Cobaltosic oxide-polyethylene glycol-triphenylphosphine\nnanoparticles\nameliorate the acute-to-chronic kidney disease transition by inducing\nBNIP3-mediated mitophagy","volume":"103","author":"Qin","year":"2023","journal-title":"Kidney Int."},{"issue":"9","key":"2026101408094342600_cit48","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis\nand mitochondrial dynamic regulatory\nnetworks","volume":"19","author":"Li","year":"2023","journal-title":"Int. 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