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J. Presl. (CC) is an important medicinal and edible plant with significant therapeutic potential and economic value. This review summarizes its major chemical constituents, including volatile oils, polysaccharides, flavonoids, phenolics, phenylpropanoids, and terpenoids, together with their pharmacological activities, such as antioxidant, anti-inflammatory, antimicrobial, hypoglycemic, neuroprotective, and cardiovascular protective effects. To improve quality evaluation and standardization, potential quality markers (Q-markers) are systematically identified based on phylogeny, measurability, traceability, pharmacological efficacy, and preparation characteristics. Unlike previous reviews, this work comprehensively integrates the nutritional profile, Q-marker characterization, pharmacodynamic prediction, botanical features, toxicological safety, clinical applications, and advanced drug delivery systems of CCs. This review provides a comprehensive theoretical basis for the quality control, rational utilization, and clinical translation of CC.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06159","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:02:15Z","timestamp":1786705335000},"page":"25804-25848","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Analysis\nof\n                    <i>Cinnamomum cassia<\/i>\n                    (L.) J. Presl.: Chemical Composition,\nPharmacological Effects, Q-Marker\nPrediction, and Therapeutic Mechanism Exploration"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-0603","authenticated-orcid":true,"given":"Qingquan","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianping","family":"Feng","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1427-4868","authenticated-orcid":true,"given":"Yongtai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"19","key":"2026090104483444900_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24193473","article-title":"Cinnamomum cassia Presl: A Review\nof Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"},{"issue":"9","key":"2026090104483444900_cit2","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1080\/10408390902773052","article-title":"Cinnamon and\nhealth","volume":"50","author":"Gruenwald","year":"2010","journal-title":"Crit Rev. 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Ethnopharmacol."},{"issue":"1","key":"2026090104483444900_cit10","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology:\ntowards the\nartificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief Bioinform."},{"key":"2026090104483444900_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153535","article-title":"Discovery of potential\nQ-marker of traditional Chinese medicine based on plant metabolomics\nand network pharmacology: Periplocae Cortex as an example","volume":"85","author":"Li","year":"2021","journal-title":"Phytomedicine"},{"issue":"44","key":"2026090104483444900_cit12","doi-asserted-by":"publisher","first-page":"27461","DOI":"10.1039\/D1RA04965H","article-title":"A review: the botany, ethnopharmacology, phytochemistry, pharmacology\nof Cinnamomi cortex","volume":"11","author":"Liu","year":"2021","journal-title":"RSC Adv."},{"key":"2026090104483444900_cit13","unstructured":"National Plant Specimen Resource Center.\n          . 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