{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:45:12Z","timestamp":1792784712190,"version":"4.5.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Anhui Province Key Cultivation Project for Excellent Young Teachers in Universities","award":["YQZD2025018"],"award-info":[{"award-number":["YQZD2025018"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82304190"],"award-info":[{"award-number":["82304190"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>3-Monochloro-1,2-propanediol (3-MCPD), a common food contaminant, induces fetal growth restriction in mice by triggering senescence in the placental vasculature. Transcriptomic analysis reveals suppression of the taurine\u2013hypotaurine pathway through downregulation of Fmo1. Mechanistically, 3-MCPD upregulates Ezh2, which deposits repressive H3K27me3 marks at the Fmo1 promoter, silencing its transcription and depleting placental taurine. Taurine supplementation or Ezh2 inhibition rescues 3-MCPD-induced vascular senescence in human endothelial cells. These findings identify an Ezh2\u2013taurine axis essential for placental vascular health, and establish a mechanistic framework for how a widespread food pollutant disrupts this pathway to cause adverse pregnancy outcomes. This work highlights taurine as a potential nutritional intervention against 3-MCPD developmental toxicity, offering a dietary strategy for protecting at-risk pregnancies.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06392","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:01:56Z","timestamp":1789567316000},"page":"30323-30336","source":"Crossref","is-referenced-by-count":0,"title":["Gestational Exposure\nto the Food Processing Contaminant\n3-MCPD Impairs Fetal Growth by Disrupting Placental Taurine\nMetabolism to Drive Vascular Senescence"],"prefix":"10.1021","volume":"74","author":[{"given":"Yanfei","family":"He","sequence":"first","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Song","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Anhui Medical University , , ,","place":["Hefei, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Xie","sequence":"additional","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlin","family":"Yang","sequence":"additional","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazuo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengpeng","family":"Xia","sequence":"additional","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-2503","authenticated-orcid":true,"given":"Lingli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-6742","authenticated-orcid":true,"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-0979","authenticated-orcid":true,"given":"Tian","family":"Wei","sequence":"additional","affiliation":[{"name":"Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230032"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"Suppl_7","key":"2026093009071234700_cit1","doi-asserted-by":"publisher","first-page":"729S","DOI":"10.1093\/ajcn\/nqy353","article-title":"Dietary\npatterns before and during pregnancy and birth outcomes: a systematic\nreview","volume":"109","author":"Ramkripa","year":"2019","journal-title":"Am. 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