{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:07:53Z","timestamp":1785337673812,"version":"3.55.0"},"reference-count":25,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Apple polyphenols are key determinants of fruit quality and potential health-related properties, yet their association with fruit mineral composition remains insufficiently characterized at the cultivar scale. We quantified five minerals (K, S, P, Mg, Ca) by ICP-OES and 13 polyphenol variables by HPLC-MS across 140 dessert apple cultivars (Malus domestica) grown under common conditions. FDR-corrected Pearson correlations revealed selective, compound-specific patterns, with potassium and phosphorus showing the strongest positive associations with chlorogenic acid (K: r = 0.55, q = 1.2 \u00d7 10\u201310; P: r = 0.43, q = 2.7 \u00d7 10\u20136), both robust under Spearman analysis. Partial correlations identified potassium as the dominant independent correlate (partial r = 0.39, q = 6.5 \u00d7 10\u20135), while phosphorus, sulfur, and magnesium associations reflected collinearity with potassium. PLS showed only modest coupling (Q2 \u2248 0.06, R2Y \u2248 0.13). Exploratory sulfur\u2013chlorogenic acid and calcium\u2013cyanidin patterns remain preliminary; findings represent cultivar-scale associations, not orchard-management recommendations.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06394","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:15:35Z","timestamp":1784164535000},"page":"22908-22918","source":"Crossref","is-referenced-by-count":0,"title":["Associations between\nFruit Mineral Composition and\nPolyphenol Profiles across 140 Dessert Apple Cultivars (\n                    <i>Malus domestica<\/i>\n                    )"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8635-4825","authenticated-orcid":true,"given":"Eleonora","family":"Zickenheiner","sequence":"first","affiliation":[{"name":"Humboldt-Universita\u0308t Zu Berlin , , Invalidenstra\u00dfe 42 , ,","place":["Berlin, Germany, 10115"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026072910063422800_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plaphy.2013.05.009","article-title":"Plant phenolics: Recent advances on their biosynthesis,\ngenetics, and ecophysiology","volume":"74","author":"Cheynier","year":"2013","journal-title":"Plant Physiol.\nBiochem."},{"key":"2026072910063422800_cit2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fchem.2018.00052","article-title":"Anthocyanin biosynthesis\nand degradation mechanisms\nin Solanaceous vegetables: A review","volume":"6","author":"Liu","year":"2018","journal-title":"Front.\nChem."},{"issue":"1","key":"2026072910063422800_cit3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/antiox7010020","article-title":"Polyphenolic\nCompounds Analysis of Old and New Apple Cultivars and Contribution\nof Polyphenolic Profile to the In Vitro Antioxidant Capacity","volume":"7","author":"Kschonsek","year":"2018","journal-title":"Antioxidants"},{"issue":"2","key":"2026072910063422800_cit4","first-page":"121","article-title":"Chemical compositional properties and mineral contents\nof some apple cultivars","volume":"1","author":"Er","year":"2010","journal-title":"South West. J. Hortic.\nBiol. Environ."},{"key":"2026072910063422800_cit5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/B978-0-12-818732-6.00003-4","article-title":"Nutrient redistribution\nin fruit crops: Physiological implications","volume-title":"Fruit Crops: diagnosis and Management of Nutrient Constraints","author":"Botelho","year":"2020"},{"issue":"4","key":"2026072910063422800_cit6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.31883\/pjfns\/127635","article-title":"Phenolic Compounds from Apples: Reviewing their Occurrence,\nAbsorption, Bioavailability, Processing, and Antioxidant Activity\n\u2013 a Review","volume":"70","author":"Starowicz","year":"2020","journal-title":"Pol. J. Food Nutr. Sci."},{"key":"2026072910063422800_cit7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00217-020-03624-7","article-title":"Study of polyphenols,\nantioxidant capacity and minerals\nfor the valorisation of ancient apple cultivars from Northeast Italy","volume":"247","author":"Preti","year":"2021","journal-title":"Eur. Food Res. Technol."},{"issue":"5","key":"2026072910063422800_cit8","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.3390\/plants12051160","article-title":"Autochthonous\nApple Cultivars from the Campania Region (Southern Italy): Bio-Agronomic\nand Qualitative Traits","volume":"12","author":"Cice","year":"2023","journal-title":"Plants"},{"key":"2026072910063422800_cit9","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1094\/PDIS-12-15-1416-RE","article-title":"Integrated control\nof apple scab and powdery mildew in an organic\napple orchard by combining potassium carbonates with wettable sulfur,\npruning, and cultivar susceptibility","volume":"100","author":"Holb","year":"2016","journal-title":"Plant\nDis."},{"key":"2026072910063422800_cit10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/9781118060841.ch8","article-title":"Bitter pit in apple fruit","volume":"11","author":"Ferguson","year":"1989","journal-title":"Hortic.\nRev."},{"issue":"14","key":"2026072910063422800_cit11","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.1002\/jsfa.9087","article-title":"Control efficacy\nof Ca-containing foliar fertilizers on bitter pit\nin bagged \u2018Fuji\u2019 apple and effects on the Ca and N contents\nof apple fruits and leaves","volume":"98","author":"Yu","year":"2018","journal-title":"J. Sci. Food Agric."},{"issue":"1","key":"2026072910063422800_cit12","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1039\/C5JA00294J","article-title":"Microwave-assisted\ndigestion using diluted acid and base solutions for plant analysis\nby ICP OES","volume":"31","author":"Barros","year":"2016","journal-title":"J. Anal. At. Spectrom."},{"key":"2026072910063422800_cit13","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.3390\/plants11202710","article-title":"Edible Wild Vegetables Urtica dioica\nL. and Aegopodium podagraria L.\u2500Antioxidants Affected by Processing","volume":"11","author":"Engelhardt","year":"2022","journal-title":"Plants"},{"key":"2026072910063422800_cit14","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.3390\/molecules26092647","article-title":"Relationship\nbetween Phenolic Compounds, Antioxidant Properties, and the Allergenic\nProtein Mal d 1 in Different Selenium-Biofortified Apple Cultivars\n(Malus domestica)","volume":"26","author":"Groth","year":"2021","journal-title":"Molecules"},{"key":"2026072910063422800_cit15","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate:\nA practical and\npowerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R.\nStat. Soc. Ser. B"},{"key":"2026072910063422800_cit16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0169-7439(01)00155-1","article-title":"PLS-regression: A basic\ntool of chemometrics","volume":"58","author":"Wold","year":"2001","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"2026072910063422800_cit17","doi-asserted-by":"crossref","DOI":"10.1201\/9781315370279","volume-title":"Generalized Additive\nModels: an Introduction with R","author":"Wood","year":"2017","edition":"2nd"},{"issue":"3","key":"2026072910063422800_cit18","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/15538362.2019.1616653","article-title":"ANovel\nApproach for Predicting Yield of Seeds in Ficus Fruits Using A Non-Parametric\nMethod","volume":"20","author":"Jayarathna","year":"2020","journal-title":"Int. J. Fruit Sci."},{"issue":"4","key":"2026072910063422800_cit19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227726","article-title":"Degree day\nmodels to forecast the seasonal phenology of Drosophila suzukii in\ntart cherry orchards in the Midwest U.S","volume":"15","author":"Kamiyama","year":"2020","journal-title":"PLoS\nOne"},{"key":"2026072910063422800_cit20","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/mp\/ssp106","article-title":"Phenylpropanoid\nbiosynthesis","volume":"3","author":"Vogt","year":"2010","journal-title":"Mol. Plant"},{"key":"2026072910063422800_cit21","doi-asserted-by":"publisher","first-page":"958490","DOI":"10.3389\/fpls.2022.958490","article-title":"Redox regulation of\nenzymes involved in sulfate assimilation and in the synthesis of sulfur-containing\namino acids and glutathione in plants","volume":"13","author":"de Bont","year":"2022","journal-title":"Front.\nPlant Sci."},{"key":"2026072910063422800_cit22","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.1093\/jxb\/erz319","article-title":"Sulfur nutrition:\nImpacts on plant\ndevelopment, metabolism, and stress responses","volume":"70","author":"Kopriva","year":"2019","journal-title":"J. Exp. Bot."},{"issue":"6","key":"2026072910063422800_cit23","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/nbt966","article-title":"Engineering\nplants with increased\nlevels of the antioxidant chlorogenic acid","volume":"22","author":"Niggeweg","year":"2004","journal-title":"Nat. Biotechnol."},{"issue":"3\u20134","key":"2026072910063422800_cit24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0304-4238(01)00290-4","article-title":"Relationships between fruit nutrients and concentrations\nof flavonoids and chlorogenic acid in \u2018Elstar\u2019 apple\nskin","volume":"92","author":"Awad","year":"2002","journal-title":"Sci. Hortic."},{"issue":"1","key":"2026072910063422800_cit25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1399-3054.2004.00427.x","article-title":"Effects of nitrogen\nsupply on growth, contents of phenolic\ncompounds and pathogen (scab) resistance of apple trees","volume":"123","author":"Leser","year":"2005","journal-title":"Physiol. Plant."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c06394","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/29\/22908\/65967617\/acs.jafc.6c06394.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/29\/22908\/65967617\/acs.jafc.6c06394.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:26:39Z","timestamp":1785335199000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/29\/22908\/5211373\/Associations-between-Fruit-Mineral-Composition-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":25,"journal-issue":{"issue":"29","published-online":{"date-parts":[[2026,7,15]]},"published-print":{"date-parts":[[2026,7,29]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c06394","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]}}}