{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:07:24Z","timestamp":1788991644851,"version":"build-2803163510"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011105"],"award-info":[{"award-number":["2024A1515011105"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22278159"],"award-info":[{"award-number":["22278159"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cyclodextrin glucanotransferase (CGTase)-catalyzed glycosylation is an effective approach to improve flavonoid solubility and bioavailability, while poor substrate solubility and low selectivity often limit its practical application. Herein, a polysaccharide-based sugar\u2013aqueous system coupled with cascade glycosylation\u2013hydrolysis was developed for selective glycosylation of trilobatin. Compared with conventional organic solvents and deep eutectic solvents, the sugar\u2013aqueous system significantly enhanced catalytic performance, achieving 83.62% conversion with \u03b1-cyclodextrin. Subsequent amyloglucosidase hydrolysis enabled the selective enrichment of trilobatin 4\u2033-O-\u03b1-D-glucopyranoside with a 97.66% purity. Kinetic analysis showed improved enzyme\u2013substrate affinity, while circular dichroism and molecular docking suggested favorable enzyme stability and substrate\u2013polysaccharide interactions that contributed to enhanced glycosylation. These results indicate that polysaccharide-based aqueous systems can promote catalytic efficiency and selectivity beyond their roles as glycosyl donors and solubilizing media, providing a mild and sustainable strategy for producing functional flavonoid glycosides.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06400","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:24:50Z","timestamp":1788222290000},"page":"27731-27742","source":"Crossref","is-referenced-by-count":0,"title":["Selective Enrichment\nof \u03b1-Glucosylated\nTrilobatin via Cascade Enzymatic Glycosylation\u2013Hydrolysis in\nPolysaccharide-Based Aqueous Reaction Systems"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0555-3299","authenticated-orcid":true,"given":"Xiaohan","family":"Liu","sequence":"first","affiliation":[{"name":"South China University of Technology , , Wushan Road 381 , ,","place":["Guangzhou, China, 510641"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Wushan Road 381 , ,","place":["Guangzhou, China, 510641"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runyu","family":"Yao","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Wushan Road 381 , ,","place":["Guangzhou, China, 510641"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-6296","authenticated-orcid":true,"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Wushan Road 381 , ,","place":["Guangzhou, China, 510641"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-1612","authenticated-orcid":true,"given":"Guanglei","family":"Zhao","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Wushan Road 381 , ,","place":["Guangzhou, China, 510641"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"11","key":"2026090917071220000_cit1","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.1039\/D2FO00245K","article-title":"Effects of Natural Dihydrochalcones\nin Sweet Tea (Lithocarpus Polystachyus) on Diabetes:\nA Systematical Review and Meta-Analysis of Animal Studies","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct"},{"key":"2026090917071220000_cit2","doi-asserted-by":"publisher","first-page":"116056","DOI":"10.1016\/j.indcrop.2022.116056","article-title":"Identification and\nFunctional Analysis of Glycosyltransferase Catalyzing\nthe Synthesis of Phlorizin and Trilobatin in Lithocarpus Polystachyus\nRehd","volume":"192","author":"Zhang","year":"2023","journal-title":"Ind. 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