{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:25:55Z","timestamp":1787153155906,"version":"build-2736575974"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0214300"],"award-info":[{"award-number":["2024YFE0214300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>4-Hydroxyphenylpyruvate dioxygenase (HPPD) has become an attractive target for herbicide development owing to the slow development and low risk of resistance to its inhibitors. However, most available HPPD inhibitors exhibit limited crop selectivity and poor efficacy against grasses. Therefore, the exploration of novel molecular scaffolds is of great research value. In this study, we adopted a ring-fusion strategy to enhance \u03c0\u2013\u03c0 stacking interactions and developed a structurally novel pyrazole-4-chloro-benzimidazolin-2-one scaffold. Through systematic structural optimization, compound II-19 showed the strongest enzyme inhibitory activity, with an IC50 of 52 nM, about 6-fold higher potency than the positive control, mesotrione. The crystal structure of AtHPPD-II-19 revealed that the inhibitor engages in characteristic chelation and \u03c0\u2013\u03c0 stacking interactions within the active site, and the 3-NO2-benzyl group contributes additional hydrophobic interactions and a possible weak water-mediated interaction involving Gln293. Additionally, I-5 showed excellent broad-spectrum weed control and good safety toward peanut at 30 g a.i.\/ha. These results indicate that compound I-5 is a promising candidate for the development of new HPPD inhibitors for weed control in peanut fields.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06453","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:02:07Z","timestamp":1786356127000},"page":"25119-25128","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Pyrazole-Benzimidazolin-2-One Derivatives\nas 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors"],"prefix":"10.1021","volume":"74","author":[{"given":"Biao","family":"Li","sequence":"first","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4288-7922","authenticated-orcid":true,"given":"Rui-Ning","family":"Ying","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Quan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Cynda (chemical) CO., Ltd. Boxing Economic Development , , ,","place":["Binzhou, Shandong, P. R. China, 256500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5627-3708","authenticated-orcid":true,"given":"Hong-Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-0921","authenticated-orcid":true,"given":"Da-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-2593","authenticated-orcid":true,"given":"Guang-Fu","family":"Yang","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"9","key":"2026081910170435300_cit1","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1002\/ps.3710","article-title":"Resistance\nto AHAS inhibitor herbicides: current understanding","volume":"70","author":"Yu","year":"2014","journal-title":"Pest Manag. Sci."},{"key":"2026081910170435300_cit2","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1038\/s41467-022-31023-x","article-title":"Structural basis\nof resistance to herbicides that target acetohydroxyacid synthase","volume":"13","author":"Lonhienne","year":"2022","journal-title":"Nat. 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