{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:06:20Z","timestamp":1789567580936,"version":"build-2803163510"},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202401010ZYTS"],"award-info":[{"award-number":["YDZJ202401010ZYTS"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prunella vulgaris polysaccharide (PVP) possesses multiple bioactivities, yet its role in ulcerative colitis (UC) remains undefined. In this study, the effects of PVP were examined in mice with a DSS-induced colitis. In this colitis model, PVP treatment markedly reduced colonic inflammation and maintained the tight junction integrity. Meanwhile, PVP-enriched beneficial gut microbiota. Further research has revealed that PVP-modulated microbiota alone are sufficient to relieve UC symptoms. Mechanistically, PVP-enriched Ligilactobacillus agilis (Lig. agilis) subsequently enhanced tight junction protein expression and attenuated inflammation. In summary, these data suggest that PVP mitigates DSS-driven colitis, an effect mediated by enriching Lig. Agilis to suppress inflammation and maintain intestinal barrier integrity, and such effects point to the therapeutic value of PVP for treating UC.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06508","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:24:55Z","timestamp":1788495895000},"page":"28498-28509","source":"Crossref","is-referenced-by-count":0,"title":["<i>Prunella vulgaris<\/i>\n                    Polysaccharide\nAmeliorates DSS-Induced Ulcerative Colitis by Increasing the Abundance\nof\n                    <i>Ligilactobacillus agilis<\/i>\n                    to Inhibit\nInflammation and Preserve Intestinal Barrier Integrity"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3777-1465","authenticated-orcid":true,"given":"Zheyu","family":"Song","sequence":"first","affiliation":[{"name":"China-Japan Union Hospital of Jilin University , , ,","place":["Changchun, China, 130033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Hou","sequence":"additional","affiliation":[{"name":"China-Japan Union Hospital of Jilin University , , ,","place":["Changchun, China, 130033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunze","family":"Ban","sequence":"additional","affiliation":[{"name":"Meihekou Central Hospital , , ,","place":["Meihekou, Jilin, China, 135000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[{"name":"China-Japan Union Hospital of Jilin University , , ,","place":["Changchun, China, 130033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6472-6310","authenticated-orcid":true,"given":"Lu","family":"Hou","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine , , ,","place":["Changchun, China, 130117"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"2026091609094491600_cit1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.synbio.2026.06.005","article-title":"Lactiplantibacillus\nplantarum as a multifunctional probiotic for inflammatory bowel disease:\nMechanisms, synbiotic strategies, and delivery systems","volume":"16","author":"Tao","year":"2027","journal-title":"Synth. 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