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Here, intestinal epithelial Bmal1 deletion in HFD-fed mice reduced weight gain, improved glucose and lipid homeostasis, and attenuated hepatic steatosis. These changes were accompanied by coordinated regulation of hepatic lipid metabolic pathways, altered bile acid-related signaling along the gut\u2013liver axis, and selective remodeling of the HFD-associated gut microbiota. Targeted analysis further revealed distinct shifts in circulating and fecal bile acid profiles. Fecal microbiota transplantation from HFD-fed Bmal1-deficient donors was associated with similar hepatic metabolic and bile acid-related changes in HFD-fed recipients. Together, these findings support a model in which intestinal epithelial Bmal1 contributes to HFD-induced hepatic lipid dysmetabolism in association with microbiota-associated bile acid remodeling.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06528","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:01:29Z","timestamp":1789110089000},"page":"29252-29265","source":"Crossref","is-referenced-by-count":0,"title":["Intestinal Epithelial\nBmal1 Contributes to High-Fat\nDiet\u2013Induced Hepatic Lipid Dysmetabolism through Microbiota-Associated\nBile Acid Remodeling"],"prefix":"10.1021","volume":"74","author":[{"given":"Zhenting","family":"Zhao","sequence":"first","affiliation":[{"name":"Northwest A&F University , , ,","place":["Yangling, China, 712100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxi","family":"Dong","sequence":"additional","affiliation":[{"name":"Northwest A&F University , , ,","place":["Yangling, China, 712100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Xin","sequence":"additional","affiliation":[{"name":"Northwest A&F University , , ,","place":["Yangling, China, 712100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Wang","sequence":"additional","affiliation":[{"name":"Northwest A&F University , , ,","place":["Yangling, China, 712100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-2868","authenticated-orcid":true,"given":"Xuebo","family":"Liu","sequence":"additional","affiliation":[{"name":"Northwest A&F University , , ,","place":["Yangling, China, 712100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-9902","authenticated-orcid":true,"given":"Beita","family":"Zhao","sequence":"additional","affiliation":[{"name":"Northwest A&F University , , ,","place":["Yangling, China, 712100"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"issue":"1","key":"2026092310071414200_cit1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s00125-010-1895-5","article-title":"Adipose triacylglycerol\nlipase is a major regulator of hepatic lipid metabolism but not insulin\nsensitivity in mice","volume":"54","author":"Turpin","year":"2011","journal-title":"Diabetologia"},{"issue":"12","key":"2026092310071414200_cit2","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41574-019-0256-9","article-title":"The regulation of\nhepatic fatty acid synthesis and\npartitioning: the effect of nutritional state","volume":"15","author":"Hodson","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"7503","key":"2026092310071414200_cit3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role\nof hepatic\nlipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"issue":"2","key":"2026092310071414200_cit4","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jhep.2010.06.044","article-title":"Effects of a high-fat diet on energy metabolism and\nROS production in rat liver","volume":"54","author":"Vial","year":"2011","journal-title":"J. Hepatol."},{"issue":"5","key":"2026092310071414200_cit5","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/hep.20920","article-title":"Insulin resistance: a metabolic pathway\nto chronic liver disease","volume":"42","author":"Bugianesi","year":"2005","journal-title":"Hepatology"},{"issue":"2","key":"2026092310071414200_cit6","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1152\/physrev.00024.2006","article-title":"Disordered\nlipid metabolism and the\npathogenesis of insulin resistance","volume":"87","author":"Savage","year":"2007","journal-title":"Physiol.\nRev."},{"issue":"7","key":"2026092310071414200_cit7","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/s42255-023-00843-6","article-title":"Liver insulinization\nas a driver\nof triglyceride dysmetabolism","volume":"5","author":"Cook","year":"2023","journal-title":"Nat. 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