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Confronting the dual challenges of structural rigidity and declining antifungal performance in conventional succinate dehydrogenase inhibitors (SDHIs), this study developed novel syringic acid derivatives. Notably, W11 exhibited remarkable broad-spectrum potency against eight phytopathogenic fungi and two oomycete species, with EC50 values of 0.679, 0.424, and 0.384 \u03bcg\/mL against Gibberella zeae, Alternaria solani, and Colletotrichum fructicola, respectively. This activity significantly surpassed that of the commercial fungicide boscalid (EC50 &amp;gt;25.0, 0.826, and &amp;gt;25.0 \u03bcg\/mL). Interestingly, W11 exhibited excellent succinate dehydrogenase inhibitory activity, causing a marked increase in intracellular reactive oxygen species (ROS), severe mitochondrial damage, and ultimately cell death. Overall, this work presents a structure-driven strategy that expands the antifungal spectrum of SDHIs and offers a promising scaffold for developing eco-friendly agrochemicals to address both limited antifungal activity and emerging oomycete challenges in sustainable agriculture.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06805","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:02:19Z","timestamp":1788570139000},"page":"28268-28283","source":"Crossref","is-referenced-by-count":0,"title":["Identification\nof Syringic Hydrazide Derivatives as\nPromising Succinate Dehydrogenase Inhibitors with Superior Antifungal\nand Anti-Oomycete Efficacy for Ensuring Food Safety"],"prefix":"10.1021","volume":"74","author":[{"given":"Yuanyuan","family":"Wu","sequence":"first","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 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