{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:07:19Z","timestamp":1789567639794,"version":"build-2803163510"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1801100"],"award-info":[{"award-number":["2023YFD1801100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32473099"],"award-info":[{"award-number":["32473099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hainan Province Science and Technology Special Fund","award":["ZDYF2023XDNY038"],"award-info":[{"award-number":["ZDYF2023XDNY038"]}]},{"name":"Hainan Province Science and Technology Special Fund","award":["ZDYF2024XDNY198"],"award-info":[{"award-number":["ZDYF2024XDNY198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bovine mastitis caused by enteropathogenic Escherichia coli (EPEC) poses a significant threat to the dairy industry, and antimicrobial resistance underscores the urgent need for novel therapeutics. Here, we show that the engineered antimicrobial peptide Z-d14CFR exerts dual protective effects against EPEC-induced mastitis through direct bactericidal activity and host-directed modulation of mitochondrial dynamics. Z-d14CFR disrupts bacterial membranes, induces oxidative stress in EPEC, and alleviates mammary tissue damage and NLRP3 inflammasome activation in a murine mastitis model. Mechanistically, EPEC infection induces dynamin-related protein 1 (Drp1)-mediated mitochondrial hyper-fission and dysfunction, whereas Z-d14CFR restores mitochondrial dynamics by promoting fusion protein expression and suppressing excessive fission, thereby reducing ROS production and downstream NLRP3-driven inflammation. Using pharmacological inhibition and genetic modification (knockout and overexpression) of Drp1, we found that the protective effects of Z-d14CFR are dependent on Drp1-mediated mitochondrial dynamics. These findings indicate Z-d14CFR as a promising dual-function candidate for combating bacterial mastitis and addressing antimicrobial resistance.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06812","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:11:11Z","timestamp":1788405071000},"page":"28284-28297","source":"Crossref","is-referenced-by-count":0,"title":["Engineered Antimicrobial\nPeptide Z-d14CFR Protects\nAgainst Mastitis through Modulation of Drp1-Mediated Host Mitochondrial\nDynamics"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8442-6574","authenticated-orcid":true,"given":"Wenwen","family":"Meng","sequence":"first","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, P. R. China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Agricultural University , , ,","place":["Hohhot, P. R. China, 010018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, P. R. China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, P. R. China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jian","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, P. R. China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohong","family":"Zhu","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, P. R. China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-5611","authenticated-orcid":true,"given":"Jiufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, P. R. China, 100193"]},{"name":"Sanya Institute of China Agricultural University , ,","place":["Sanya, P. R. China, 572025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Danzhou Luoniushan Agricultural Technology Development Co., Ltd. , ,","place":["Danzhou, P. R. China, 571700"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjing","family":"Zou","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, P. R. China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, P. R. China, 100193"]},{"name":"Sanya Institute of China Agricultural University , ,","place":["Sanya, P. R. 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