{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:44Z","timestamp":1792784684981,"version":"4.5.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010083","name":"Hunan Provincial Innovation Foundation for Postgraduate","doi-asserted-by":"publisher","award":["CX20251260"],"award-info":[{"award-number":["CX20251260"]}],"id":[{"id":"10.13039\/501100010083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2019TP1029"],"award-info":[{"award-number":["2019TP1029"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","award":["GJFP20230204"],"award-info":[{"award-number":["GJFP20230204"]}],"id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","award":["2024JK2158"],"award-info":[{"award-number":["2024JK2158"]}],"id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["U24A20466"],"award-info":[{"award-number":["U24A20466"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["U25A20730"],"award-info":[{"award-number":["U25A20730"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Forestry Science and Technology Innovation Project in Hunan Province","award":["XLK2024"],"award-info":[{"award-number":["XLK2024"]}]},{"name":"State Key Laboratory of Utilization of Woody Oil Resource","award":["SKL-CSUFT202503"],"award-info":[{"award-number":["SKL-CSUFT202503"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously reported that Lactarius hatsudake Tanaka polysaccharide (LHP) can inhibit hepatocellular carcinoma, but the mechanism remains unclear especially gut microbe-mediated antitumor immunity. This research found that LHP and fecal microbiota transplantation were associated with reduced tumor growth. The ratio of CD8+\/CD4+ T cells and levels of interferon-\u03b3 were increased following LHP intervention in the tumor, spleen, and blood. Additionally, in vivo and in vitro microbiome analyses indicated that LHP treatment significantly increased beneficial bacteria such as Bifidobacterium animalis while reducing Lactobacillus murinus. Furthermore, metabolomic analyses suggested that LHP may be metabolized into propionate via the succinate pathway, accompanied by changes in the microbial composition, which significantly inhibit the arginine and tryptophan metabolic pathways. These microbial and metabolite changes paralleled improvements in the tumor immune microenvironment and coincided with attenuated hepatocellular carcinoma progression. These findings suggest that LHP-induced gut microbiota remodeling is associated with antitumor immune modulation.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06885","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:02:17Z","timestamp":1790146937000},"page":"30768-30783","source":"Crossref","is-referenced-by-count":0,"title":["<i>Lactarius hatsudake<\/i>\n                    Tanaka Polysaccharides\nInhibit Hepatocellular Carcinoma by Modulating the Gut Microbiota\nand Its Metabolites"],"prefix":"10.1021","volume":"74","author":[{"given":"Songlin","family":"Chang","sequence":"first","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Zha","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiao","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Zhou","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Tian","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9457-5037","authenticated-orcid":true,"given":"Wang","family":"Li","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6942-3214","authenticated-orcid":true,"given":"Jiali","family":"Ren","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026100711070634500_cit1","doi-asserted-by":"publisher","first-page":"118558","DOI":"10.1016\/j.carbpol.2021.118558","article-title":"Edible fungal polysaccharides, the\ngut microbiota, and host health","volume":"273","author":"Liang","year":"2021","journal-title":"Carbohydr.\nPolym."},{"issue":"13","key":"2026100711070634500_cit2","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.3390\/molecules27134090","article-title":"Mushroom Polysaccharide-Assisted\nAnticarcinogenic Mycotherapy: Reviewing Its Clinical Trials","volume":"27","author":"Sivanesan","year":"2022","journal-title":"Molecules"},{"issue":"21","key":"2026100711070634500_cit3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038032","article-title":"Investigation on the Efficiency of\nLentinan for Injection Combining Cisplatin on Treating Malignant Pleural\nEffusion Based on Systematic Review and Meta-Analysis","volume":"103","author":"Wang","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"2026100711070634500_cit4","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.tifs.2021.11.017","article-title":"New light on Grifola frondosa polysaccharides as\nbiological response modifiers","volume":"119","author":"Zhang","year":"2022","journal-title":"Trends Food Sci.\nTechnol."},{"key":"2026100711070634500_cit5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1534735420946823","article-title":"Lentinan Inhibits\ntumor progression by immunomodulation in a mouse model of bladder\ncancer","volume":"19","author":"Sun","year":"2020","journal-title":"Integr. Cancer Ther."},{"key":"2026100711070634500_cit6","doi-asserted-by":"publisher","first-page":"122171","DOI":"10.1016\/j.carbpol.2024.122171","article-title":"Glucan\npolysaccharides isolated from Lactarius hatsudake Tanaka mushroom: Structural characterization and in vitro bioactivities","volume":"337","author":"Yang","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"2026100711070634500_cit7","doi-asserted-by":"publisher","first-page":"9250367","DOI":"10.26599\/FSHW.2024.9250367","article-title":"Anti-hepatocarcinoma\neffect of polysaccharides extracted\nfrom Lactarius hatsudake Tanaka mushroom: in vitro and in vivo studies","volume":"14","author":"Yang","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"issue":"12","key":"2026100711070634500_cit8","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s41568-022-00513-x","article-title":"Targeting\nthe gut microbiota for cancer therapy","volume":"22","author":"Fernandes","year":"2022","journal-title":"Nat.\nRev. Cancer"},{"issue":"9","key":"2026100711070634500_cit9","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41579-022-00712-1","article-title":"Carbohydrate-active\nenzymes (CAZymes) in the gut microbiome","volume":"20","author":"Wardman","year":"2022","journal-title":"Nat.\nRev. Microbiol."},{"issue":"2","key":"2026100711070634500_cit10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.immuni.2022.01.006","article-title":"Tryptophan-Derived\nMicrobial Metabolites Activate the\nAryl Hydrocarbon Receptor in Tumor-Associated Macrophages to Suppress\nAnti-Tumor Immunity","volume":"55","author":"Hezaveh","year":"2022","journal-title":"Immunity"},{"issue":"81","key":"2026100711070634500_cit11","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo2003","article-title":"Immune\nCheckpoint Blockade Induces\nGut Microbiota Translocation That Augments Extraintestinal Antitumor\nImmunity","volume":"8","author":"Choi","year":"2023","journal-title":"Sci. Immunol."},{"key":"2026100711070634500_cit12","doi-asserted-by":"publisher","first-page":"104606","DOI":"10.1016\/j.tifs.2024.104606","article-title":"The fate of dietary polysaccharides\nin the digestive tract","volume":"150","author":"Yang","year":"2024","journal-title":"Trends Food Sci. Technol."},{"issue":"1","key":"2026100711070634500_cit13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s40168-024-01896-9","article-title":"Bacteroides\nUniformis Degrades \u03b2-Glucan to Promote Lactobacillus Johnsonii\nImproving Indole-3-Lactic Acid Levels in Alleviating Colitis","volume":"12","author":"Zhang","year":"2024","journal-title":"Microbiome"},{"issue":"4","key":"2026100711070634500_cit14","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1136\/gutjnl-2020-321031","article-title":"Ginseng Polysaccharides Alter the Gut Microbiota and\nKynurenine\/Tryptophan Ratio, Potentiating the Antitumour Effect of\nAntiprogrammed Cell Death 1\/Programmed Cell Death Ligand 1 (Anti-PD-1\/PD-L1)\nImmunotherapy","volume":"71","author":"Huang","year":"2022","journal-title":"Gut"},{"key":"2026100711070634500_cit15","doi-asserted-by":"publisher","first-page":"109835","DOI":"10.1016\/j.carres.2026.109835","article-title":"Investigation of Monosaccharide\nColorimetric Efficiency by Phenol-Sulfuric Acid Method and Optimization\nof Quantitative Models for Polysaccharides","volume":"562","author":"Li","year":"2026","journal-title":"Carbohydr. Res."},{"issue":"6601","key":"2026100711070634500_cit16","doi-asserted-by":"publisher","DOI":"10.1126\/science.abp9960","article-title":"The Microbiome and Gut Homeostasis","volume":"377","author":"Lee","year":"2022","journal-title":"Science"},{"issue":"2","key":"2026100711070634500_cit17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0740-2570(03)00024-8","article-title":"Splenic\nHistology and Histopathology: An Update","volume":"20","author":"Kraus","year":"2003","journal-title":"Semin.\nDiagn. Pathol."},{"issue":"5","key":"2026100711070634500_cit18","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.cmet.2021.03.002","article-title":"Gut microbial metabolites facilitate anticancer\ntherapy efficacy\nby modulating cytotoxic CD8+ T cell immunity","volume":"33","author":"He","year":"2021","journal-title":"Cell Metab"},{"issue":"11","key":"2026100711070634500_cit19","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/s41551-021-00749-2","article-title":"Generation of systemic antitumour immunity via the\nin situ modulation\nof the gut microbiome by an orally administered inulin gel","volume":"5","author":"Han","year":"2021","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"2026100711070634500_cit20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nri3567","article-title":"Human memory\nT cells: generation,\ncompartmentalization and homeostasis","volume":"14","author":"Farber","year":"2014","journal-title":"Nat. Rev.\nImmunol."},{"issue":"11","key":"2026100711070634500_cit21","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T\ncell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"2026100711070634500_cit22","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s12967-024-05104-y","article-title":"Potential Anti-Tumor\nEffects of Regulatory T Cells\nin the Tumor Microenvironment: A Review","volume":"22","author":"Li","year":"2024","journal-title":"J.\nTransl. Med."},{"issue":"10","key":"2026100711070634500_cit23","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.immuni.2023.09.005","article-title":"CD8+ T\nCells in the Cancer-Immunity Cycle","volume":"56","author":"Giles","year":"2023","journal-title":"Immunity"},{"issue":"1","key":"2026100711070634500_cit24","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12943-018-0913-y","article-title":"Effects of tumor metabolic microenvironment on regulatory T cells","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Cancer."},{"issue":"5","key":"2026100711070634500_cit25","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s13238-020-00748-0","article-title":"Gut microbiota alterations\nare distinct for primary colorectal cancer and hepatocellular carcinoma","volume":"12","author":"Jia","year":"2021","journal-title":"Protein Cell"},{"key":"2026100711070634500_cit26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.mam.2017.06.002","article-title":"Interactions between\nGut Bacteria\nand Bile in Health and Disease","volume":"56","author":"Long","year":"2017","journal-title":"Mol. Aspects\nMed."},{"key":"2026100711070634500_cit27","doi-asserted-by":"publisher","first-page":"124291","DOI":"10.1016\/j.ijbiomac.2023.124291","article-title":"A Cold-Water Extracted Polysaccharide-Protein Complex from Grifola\nFrondosa Exhibited Anti-Tumor Activity via TLR4-NF-\u039aB Signaling\nActivation and Gut Microbiota Modification in H22 Tumor-Bearing Mice","volume":"239","author":"Zhao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"2026100711070634500_cit28","doi-asserted-by":"publisher","first-page":"1847629","DOI":"10.1080\/19490976.2020.1847629","article-title":"Bifidobacterium Animalis: The Missing Link for the Cancer-Preventive\nEffect of Gynostemma Pentaphyllum","volume":"13","author":"Liao","year":"2021","journal-title":"Gut Microbes"},{"issue":"1","key":"2026100711070634500_cit29","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s41467-024-45636-x","article-title":"Dubosiella\nNewyorkensis Modulates\nImmune Tolerance in Colitis via the L-Lysine-Activated AhR-IDO1-Kyn\nPathway","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"issue":"23","key":"2026100711070634500_cit30","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.1016\/j.cell.2023.09.011","article-title":"Arginine Reprograms\nMetabolism in Liver Cancer via RBM39","volume":"186","author":"Mossmann","year":"2023","journal-title":"Cell"},{"issue":"5","key":"2026100711070634500_cit31","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1158\/2159-8290.CD-RW2018-048","article-title":"The Kyn\u2013AhR\npathway upregulates PD-1 to promote tumor immune\nescape","volume":"8","author":"Liu","year":"2018","journal-title":"Cancer Discov."},{"issue":"6","key":"2026100711070634500_cit32","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.ccell.2014.10.002","article-title":"Inhibition of de Novo NAD(+) Synthesis by Oncogenic\nURI Causes Liver Tumorigenesis through DNA Damage","volume":"26","author":"Tummala","year":"2014","journal-title":"Cancer Cell"},{"issue":"1","key":"2026100711070634500_cit33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-022-01408-7","article-title":"Lactobacillus reuteri tryptophan metabolism promotes host\nsusceptibility to CNS autoimmunity","volume":"10","author":"Montgomery","year":"2022","journal-title":"Microbiome"},{"issue":"10","key":"2026100711070634500_cit34","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1136\/gutjnl-2020-323951","article-title":"Lactobacillus Gallinarum Modulates the Gut Microbiota and Produces Anti-Cancer\nMetabolites to Protect against Colorectal Tumourigenesis","volume":"71","author":"Sugimura","year":"2022","journal-title":"Gut"},{"issue":"7","key":"2026100711070634500_cit35","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/j.cell.2024.02.022","article-title":"Microbial Metabolite\nEnhances Immunotherapy Efficacy by Modulating T Cell Stemness in Pan-Cancer","volume":"187","author":"Jia","year":"2024","journal-title":"Cell"},{"issue":"2","key":"2026100711070634500_cit36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ccell.2021.12.001","article-title":"Reuterin\nin the Healthy Gut Microbiome Suppresses Colorectal Cancer Growth\nthrough Altering Redox Balance","volume":"40","author":"Bell","year":"2022","journal-title":"Cancer Cell"},{"issue":"9","key":"2026100711070634500_cit37","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/j.cell.2023.03.011","article-title":"Dietary Tryptophan Metabolite Released\nby Intratumoral Lactobacillus Reuteri Facilitates Immune Checkpoint\nInhibitor Treatment","volume":"186","author":"Bender","year":"2023","journal-title":"Cell"},{"issue":"6510","key":"2026100711070634500_cit38","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1126\/science.abc3421","article-title":"Microbiome-Derived\nInosine Modulates Response to Checkpoint Inhibitor Immunotherapy","volume":"369","author":"Mager","year":"2020","journal-title":"Science"},{"issue":"1","key":"2026100711070634500_cit39","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s12964-023-01219-9","article-title":"Short-Chain Fatty Acids in Diseases","volume":"21","author":"Zhang","year":"2023","journal-title":"Cell Commun.\nSignal."},{"issue":"1","key":"2026100711070634500_cit40","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/fsh3.12025","article-title":"Macro Insights into the Shared and\nDistinct Regulations of Dietary Polysaccharides on Gut Microbiota\nand Their Roles in Obesity","volume":"2","author":"Xie","year":"2024","journal-title":"Food Saf. Health"},{"issue":"4","key":"2026100711070634500_cit41","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1002\/fft2.70048","article-title":"Bioactive Polysaccharides\nTargeting Gut Microbiota to Modulate Host Health: A Gear Effect Theory","volume":"6","author":"Sun","year":"2025","journal-title":"Food Front"},{"issue":"1","key":"2026100711070634500_cit42","doi-asserted-by":"publisher","DOI":"10.1002\/efd2.141","article-title":"Fiber and\nEsophageal Cancer Prevention: Is There a Role for the Microbiome?","volume":"6","author":"Stoner","year":"2025","journal-title":"eFood"},{"key":"2026100711070634500_cit43","doi-asserted-by":"publisher","first-page":"701626","DOI":"10.3389\/fimmu.2021.701626","article-title":"Propionic\nacid rescues high-fat diet enhanced immunopathology in autoimmunity\nvia effects on Th17 responses","volume":"12","author":"Haase","year":"2021","journal-title":"Front. Immunol."},{"issue":"5","key":"2026100711070634500_cit44","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/s41396-021-01119-1","article-title":"Human Gut-Microbiome-Derived\nPropionate Coordinates Proteasomal Degradation via HECTD2 Upregulation\nto Target EHMT2 in Colorectal Cancer","volume":"16","author":"Ryu","year":"2022","journal-title":"ISME J."},{"issue":"16","key":"2026100711070634500_cit45","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.3390\/molecules26164951","article-title":"Anticancer Effects of Propionic Acid Inducing Cell\nDeath in Cervical Cancer Cells","volume":"26","author":"Pham","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"2026100711070634500_cit46","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s42003-023-04970-4","article-title":"Fungal \u03b2-Glucan-Facilitated\nCross-Feeding Activities\nbetween Bacteroides and Bifidobacterium Species","volume":"6","author":"Fernandez-Julia","year":"2023","journal-title":"Commun. Biol."},{"issue":"1","key":"2026100711070634500_cit47","doi-asserted-by":"publisher","first-page":"14430","DOI":"10.1038\/s41598-018-32860-x","article-title":"Regulation\nof the Effector Function of CD8+ T Cells by Gut Microbiota-Derived\nMetabolite Butyrate","volume":"8","author":"Luu","year":"2018","journal-title":"Sci. Rep."},{"key":"2026100711070634500_cit48","doi-asserted-by":"publisher","first-page":"1332588","DOI":"10.3389\/fimmu.2024.1332588","article-title":"GPR41 and GPR43 Regulate\nCD8+ T Cell Priming during Herpes Simplex Virus Type 1\nInfection","volume":"15","author":"Lee","year":"2024","journal-title":"Front. Immunol."},{"issue":"2","key":"2026100711070634500_cit49","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.immuni.2019.06.002","article-title":"Microbiota-Derived\nShort-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated\nCD8+ T Cells","volume":"51","author":"Bachem","year":"2019","journal-title":"Immunity"},{"issue":"5","key":"2026100711070634500_cit50","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1002\/fft2.70084","article-title":"Dietary Riboflavin\nSupplementation Suppresses Colorectal Cancer Progression by Restoring\nthe Function Effector of CD8+ T Cells","volume":"6","author":"Chen","year":"2025","journal-title":"Food Front"}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c06885","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/39\/30768\/68612532\/acs.jafc.6c06885.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/39\/30768\/68612532\/acs.jafc.6c06885.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:03:28Z","timestamp":1791389008000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/39\/30768\/5436101\/Lactarius-hatsudake-Tanaka-Polysaccharides-Inhibit"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":50,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,23]]},"published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c06885","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]}}}