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In this study, the copper-containing nitrite reductase AfNiR was identified as a novel biocatalyst for AFB1 and ZEN degradation, achieving maximum efficiencies of 99.22% and 93.53%, respectively, under optimal conditions of 40 \u00b0C, pH 7.0\u20138.0, 20 \u03bcg\/mL (0.48 \u03bcM) enzyme dosage, and 24 h incubation for 5 \u03bcg\/mL (16.01 \u03bcM) AFB1, and 50 \u00b0C, pH 8.0, 20 \u03bcg\/mL (0.48 \u03bcM) enzyme dosage, and 24 h incubation for 10 \u03bcg\/mL (31.41 \u03bcM) ZEN. UPLC\u2013MS\/MS identified AFQ1 and 15-OH-ZEN as the main transformation products, both exhibiting substantially reduced toxicity indicators in zebrafish assays. Molecular docking, site-directed mutagenesis, and molecular dynamics simulations indicated that both toxins bind near the T2 copper center and that copper-coordinating residues are essential for catalysis. To improve stability, AfNiR was immobilized in Cu3(PO4)2 nanoflowers and SA\/SDS microspheres, achieving efficient detoxification in vegetable oil without affecting oil quality.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06898","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:02:10Z","timestamp":1786680130000},"page":"26714-26734","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Copper-Containing\nNitrite Reductase for Simultaneous\nDetoxification of Aflatoxin B1 and Zearalenone: Catalytic\nMechanism and Application in Edible Oils"],"prefix":"10.1021","volume":"74","author":[{"given":"Minjie","family":"Hou","sequence":"first","affiliation":[{"name":"Henan University of Technology , , ,","place":["Zhengzhou, P. R. 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China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-5959","authenticated-orcid":true,"given":"Yanli","family":"Xie","sequence":"additional","affiliation":[{"name":"Henan University of Technology , , ,","place":["Zhengzhou, P. R. 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