{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:18:19Z","timestamp":1788254299332,"version":"build-2803163510"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005621","name":"Kasetsart University Research and Development Institute","doi-asserted-by":"publisher","award":["FF(KU)4.69"],"award-info":[{"award-number":["FF(KU)4.69"]}],"id":[{"id":"10.13039\/501100005621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"ASEA-UNINET Project Funding","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Central Laboratory and Greenhouse Complex, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pathogenic bacteria in aquaculture and agriculture remain a major challenge to food production and animal health, with substantial economic impacts worldwide. In this study, three previously undescribed naphthalene derivatives (1\u20133) and one naphthalenone (4), along with 12 known compounds, were isolated from the roots of Diospyros undulata. Naphthoquinones 5 and 7 exhibited potent antibacterial activity against several pathogens, including Staphylococcus aureus and Streptococcus agalactiae. Mechanistic studies indicated that these compounds disrupt bacterial membranes and inhibit biofilm formation. Molecular docking suggested interactions with key bacterial targets, including sortase A and FtsZ enzymes. In vivo studies in Nile tilapia demonstrated improved survival following infection when supplemented with D. undulata root extract. Additionally, compounds 5 and 12 showed cytotoxicity against human cancer cell lines, while compound 1 exhibited intracellular antioxidant activity. These findings highlight naphthoquinone derivatives from D. undulata as promising plant-derived antibacterial candidates and biomedical applications.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c06920","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T17:02:41Z","timestamp":1786640561000},"page":"26332-26350","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Constituents\nfrom Roots of\n                    <i>Diospyros undulata<\/i>\n                    as\nPromising Antibacterial Agents\u2500\n                    <i>In Vitro<\/i>\n                    ,\n                    <i>In Silico<\/i>\n                    ,\n                    <i>In Vivo<\/i>\n                    , and Cytotoxic Studies"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-1677","authenticated-orcid":true,"given":"Weerasak","family":"Songoen","sequence":"first","affiliation":[{"name":"Kasetsart University , , Kamphaeng Saen Campus , ,","place":["Nakhon Pathom, Thailand, 73140"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morakot","family":"Thabpho","sequence":"additional","affiliation":[{"name":"Kasetsart University , , Kamphaeng Saen , ,","place":["Nakhon Pathom, Thailand, 73140"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Wenisch","sequence":"additional","affiliation":[{"name":"University of Vienna , , Wa\u0308hringer Strasse 42 , ,","place":["Vienna, Austria, A-1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1319-0793","authenticated-orcid":true,"given":"Witthawat","family":"Phanchai","sequence":"additional","affiliation":[{"name":"Khon Kaen University , , ,","place":["Khon Kaen, Thailand, 40002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Brecker","sequence":"additional","affiliation":[{"name":"University of Vienna , , Wa\u0308hringer Strasse 38 , ,","place":["Vienna, Austria, A-1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchai","family":"Pluempanupat","sequence":"additional","affiliation":[{"name":"Kasetsart University , , ,","place":["Bangkok, Thailand, 10900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutthawat","family":"Chuanopparat","sequence":"additional","affiliation":[{"name":"Kasetsart University , , ,","place":["Bangkok, Thailand, 10900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-1426","authenticated-orcid":true,"given":"Michael A.","family":"Jakupec","sequence":"additional","affiliation":[{"name":"University of Vienna , , Wa\u0308hringer Strasse 42 , ,","place":["Vienna, Austria, A-1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manakorn","family":"Sukmak","sequence":"additional","affiliation":[{"name":"Kasetsart University , , Kamphaeng Saen , ,","place":["Nakhon Pathom, Thailand, 73140"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanika","family":"Winaipanich","sequence":"additional","affiliation":[{"name":"Kasetsart University , , Kamphaeng Saen , ,","place":["Nakhon Pathom, Thailand, 73140"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthana","family":"Thitichayaphong","sequence":"additional","affiliation":[{"name":"Kasetsart University , , Kamphaeng Saen , ,","place":["Nakhon Pathom, Thailand, 73140"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akkharadet","family":"Piyasaengthong","sequence":"additional","affiliation":[{"name":"Kasetsart University , , ,","place":["Bangkok, Thailand, 10900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriphan","family":"Sukkhaeng","sequence":"additional","affiliation":[{"name":"Kasetsart University , , Kamphaeng Saen Campus , ,","place":["Nakhon Pathom, Thailand, 73140"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-8736","authenticated-orcid":true,"given":"Johann","family":"Schinnerl","sequence":"additional","affiliation":[{"name":"University of Vienna , , Rennweg 14 , ,","place":["Vienna, Austria, A-1030"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"4","key":"2026090104480976600_cit1","first-page":"277","article-title":"The antibiotic\nresistance crisis: part 1: causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"issue":"6","key":"2026090104480976600_cit2","doi-asserted-by":"publisher","first-page":"598","DOI":"10.3390\/antibiotics14060598","article-title":"Antibiotic Resistance in Aquaculture:\nChallenges, Trends Analysis, and Alternative Approaches","volume":"14","author":"Mohammed","year":"2025","journal-title":"Antibiotics"},{"issue":"S1","key":"2026090104480976600_cit3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/raq.12743","article-title":"Bacterial\ndiseases of tilapia, their zoonotic potential and risk of antimicrobial\nresistance","volume":"15","author":"Haenen","year":"2023","journal-title":"Rev. Aquacult."},{"issue":"1\u20134","key":"2026090104480976600_cit4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.aquaculture.2005.01.002","article-title":"A review of the main bacterial fish\ndisease in mariculture systems","volume":"246","author":"Toranzo","year":"2005","journal-title":"Aquaculture"},{"key":"2026090104480976600_cit5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fcimb.2013.00097","article-title":"Distribution and\ndynamics of epidemic and pandemic Vibrio parahaemolyticus virulence factors","volume":"3","author":"Ceccarelli","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2026090104480976600_cit6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3354\/dao02621","article-title":"Determination of\nthe infectious nature\nof the agent of acute hepatopancreatic necrosis syndrome affecting\npenaeid shrimp","volume":"105","author":"Tran","year":"2013","journal-title":"Dis. Aquat. Organ."},{"issue":"3","key":"2026090104480976600_cit7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/vetsci12030197","article-title":"Major causative\nbacteria of dairy cow mastitis in the inner Mongolia autonomous region,\nChina, 2015\u20132024: An epidemiologic survey and analysis","volume":"12","author":"Zhao","year":"2025","journal-title":"Vet. Sci."},{"issue":"23","key":"2026090104480976600_cit8","doi-asserted-by":"publisher","first-page":"6524","DOI":"10.1021\/acs.jafc.1c01148","article-title":"Alkylated Salicylaldehydes\nand Prenylated Indole Alkaloids\nfrom the Endolichenic Fungus Aspergillus chevalieri and Their Bioactivities","volume":"69","author":"Lin","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"2026090104480976600_cit9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ijfoodmicro.2004.03.022","article-title":"Essential\noils: Their antibacterial properties and potential applications in\nfoods\u2013a review","volume":"94","author":"Burt","year":"2004","journal-title":"Int. J. Food Microbiol."},{"issue":"2","key":"2026090104480976600_cit10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijantimicag.2011.02.014","article-title":"Recent advances\nin understanding the antibacterial\nproperties of flavonoids","volume":"38","author":"Cushnie","year":"2011","journal-title":"Int. J. Antimicrob.\nAgents"},{"key":"2026090104480976600_cit11","doi-asserted-by":"publisher","first-page":"720726","DOI":"10.3389\/fphar.2021.720726","article-title":"Exploring\nphytochemicals for combating antibiotic resistance\nin microbial pathogens","volume":"12","author":"Khare","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"8","key":"2026090104480976600_cit12","doi-asserted-by":"publisher","first-page":"746","DOI":"10.3390\/antibiotics13080746","article-title":"Plant-derived\nantimicrobials and their crucial role in Ccombating antimicrobial\nresistance","volume":"13","author":"Angelini","year":"2024","journal-title":"Antibiotics"},{"issue":"4","key":"2026090104480976600_cit13","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/S0031-9422(97)01020-0","article-title":"Pharmacology and\nchemotaxonomy of Diospyros","volume":"49","author":"Mallavadhani","year":"1998","journal-title":"Phytochemistry"},{"issue":"1","key":"2026090104480976600_cit14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.18311\/jnr\/2008\/289","article-title":"A Review of phytochemical and biological\nstudies of Diospyros species used in folklore medicine\nof Jharkhand","volume":"8","author":"Sinha","year":"2008","journal-title":"J. Nat. Remedies."},{"key":"2026090104480976600_cit15","first-page":"59","article-title":"The Thai local\nwisdom of medicinal plants usage from\nPhu Dong Ee-Pia forest, Ubonratana district, Khon Kaen province","volume":"6","author":"Pathommapas","year":"2008","journal-title":"UDRU J. Sci. Technol. C"},{"issue":"10","key":"2026090104480976600_cit16","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1080\/14786419.2019.1630120","article-title":"A new cytotoxic\nplumbagin derivative from roots of Diospyros undulata","volume":"35","author":"Suchaichit","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"2026090104480976600_cit17","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.phytol.2018.02.008","article-title":"Two new naphthalenones from Diospyros undulata stem bark and their cytotoxic activity","volume":"24","author":"Suchaichit","year":"2018","journal-title":"Phytochem.\nLett."},{"key":"2026090104480976600_cit18","volume-title":"M100 Performance Standards for Antimicrobial\nSusceptibility\nTesting","author":"CLSI.","year":"2019"},{"issue":"1","key":"2026090104480976600_cit19","doi-asserted-by":"publisher","first-page":"7948","DOI":"10.1038\/s41598-025-92435-5","article-title":"Antibiofilm\nactivity of plumbagin against Staphylococcus aureus","volume":"15","author":"Bie","year":"2025","journal-title":"Sci. Rep."},{"key":"2026090104480976600_cit20","doi-asserted-by":"publisher","first-page":"1020652","DOI":"10.3389\/fmicb.2022.1020652","article-title":"Plumbagin resurrect\ncolistin susceptible against colistin-resistant Pseudomonas aeruginosa in vitro and in vivo","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"issue":"5","key":"2026090104480976600_cit21","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.006363","article-title":"Exophiala amphawaensis sp. nov., a novel black yeast isolated from\nthe gut of amphipods in Thailand","volume":"74","author":"Haranto","year":"2024","journal-title":"Int. J.\nSyst. Evol. Microbiol."},{"key":"2026090104480976600_cit22","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.aquaculture.2018.02.040","article-title":"Histological\nchanges in Nile tilapia fed essential\noils of clove basil and ginger after challenge with Streptococcus agalactiae","volume":"490","author":"Brum","year":"2018","journal-title":"Aquaculture"},{"key":"2026090104480976600_cit23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.4236\/abb.2015.63014","article-title":"Alkaline Phosphatase\n(ALP), Aspartate Aminotransferase\n(AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues\nof Rats Fed on Processed Atlantic Horse Mackerel (Trachurus trachurus)","volume":"06","author":"Talabi","year":"2015","journal-title":"Adv. Biosci. Biotechnol."},{"issue":"10","key":"2026090104480976600_cit24","article-title":"Urea\nand creatinine\nof Clarias gariepinus in three different commercial\nponds","volume":"12","author":"Ajeniyi","year":"2014","journal-title":"Nat. Sci."},{"issue":"2","key":"2026090104480976600_cit25","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/BF00350923","article-title":"Electrophoretic\nstudies of serum proteins of four Tilapia species (Pisces)","volume":"8","author":"Badawi","year":"1971","journal-title":"Marine Biol."},{"issue":"4","key":"2026090104480976600_cit26","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3390\/molecules26041078","article-title":"Highly aromatic flavan-3-ol derivatives\nfrom palaeotropical Artocarpus lacucha Buch.-Ham\npossess radical scavenging and antiproliferative properties","volume":"26","author":"Songoen","year":"2021","journal-title":"Molecules"},{"issue":"18","key":"2026090104480976600_cit27","doi-asserted-by":"publisher","first-page":"8404","DOI":"10.1021\/jf8013074","article-title":"Structure\u2013activity\nrelationships of flavonoids\nin the cellular antioxidant activity assay","volume":"56","author":"Wolfe","year":"2008","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"2026090104480976600_cit28","doi-asserted-by":"publisher","first-page":"5778","DOI":"10.1016\/j.ejmech.2011.09.012","article-title":"Anti-tumoral activities of dioncoquinones\nB and C and related naphthoquinones gained from total synthesis or\nisolation from plants","volume":"46","author":"Bringmann","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"2026090104480976600_cit29","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1016\/0031-9422(92)83750-S","article-title":"6-Hydroxyplumbagin,\na naphthoquinone from Plumbago indica","volume":"31","author":"Dinda","year":"1992","journal-title":"Phytochemistry"},{"issue":"3","key":"2026090104480976600_cit30","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1246\/bcsj.77.537","article-title":"Cytotoxic\nantifeedant\nfrom Dionaea muscipula Ellis: A defensive mechanism\nof carnivorous plants against predators","volume":"77","author":"Tokunaga","year":"2004","journal-title":"Bull.\nChem. Soc. Jpn."},{"key":"2026090104480976600_cit31","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1139\/V10-084","article-title":"Naphthalene derivatives from Diospyros wallichii","volume":"88","author":"Salae","year":"2010","journal-title":"Can. J. Chem."},{"issue":"13","key":"2026090104480976600_cit32","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1080\/14786419.2012.718770","article-title":"A new dimeric\nnaphthoquinone from Diospyros anisandra","volume":"27","author":"Uc-Cacho\u0301n","year":"2013","journal-title":"Nat. Prod. Res."},{"issue":"10","key":"2026090104480976600_cit33","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1016\/S0031-9422(00)80563-4","article-title":"Isolation and structures\nof diomuscinone\nand diomuscipulone from Dionaea muscipula","volume":"23","author":"Miyoshi","year":"1984","journal-title":"Phytochemistry"},{"issue":"8","key":"2026090104480976600_cit34","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1002\/ddr.21599","article-title":"Discovery of natural\nnaphthoquinones as sortase A inhibitors and potential anti-infective\nsolutions against Staphylococcus aureus","volume":"80","author":"Nitulescu","year":"2019","journal-title":"Drug Dev. Res."},{"key":"2026090104480976600_cit35","doi-asserted-by":"publisher","first-page":"128192","DOI":"10.1016\/j.bmcl.2021.128192","article-title":"Antimicrobial, modulatory,\nand antibiofilm activity of tt-farnesol on bacterial and fungal strains\nof importance to human health","volume":"47","author":"Lopes","year":"2021","journal-title":"Bioorg. Med.\nChem. Lett."},{"issue":"18","key":"2026090104480976600_cit36","doi-asserted-by":"publisher","first-page":"4585","DOI":"10.1111\/febs.12429","article-title":"Plumbagin\ninhibits cytokinesis in Bacillus subtilis by inhibiting\nFtsZ assembly\u2013a mechanistic study of its antibacterial activity","volume":"280","author":"Bhattacharya","year":"2013","journal-title":"FEBS J."},{"key":"2026090104480976600_cit37","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23551","article-title":"Pathogenicity of Streptococcus agalactiae in Oreochromis niloticus","volume":"0","author":"He","year":"2018","journal-title":"Oncotarget"},{"issue":"1","key":"2026090104480976600_cit38","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1939-165X.2000.tb00389.x","article-title":"Hematology and plasma chemistry reference\nintervals for cultured Tilapia (Oreochromis Hybrid)","volume":"29","author":"Hrubec","year":"2000","journal-title":"Vet. Clin. Pathol."},{"key":"2026090104480976600_cit39","doi-asserted-by":"publisher","first-page":"200168","DOI":"10.1016\/j.cirep.2024.200168","article-title":"Health\nstatus biomarkers and hemato-biochemical indices in Nile tila\u0301pia","volume":"7","author":"Bavia","year":"2024","journal-title":"Compar. Immun. Rep."},{"issue":"3","key":"2026090104480976600_cit40","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1638\/06-025.1","article-title":"Hematologic\nand plasma biochemical\nvalues of healthy hybrid Tilapia (Oreochromis aureus \u00d7 Oreochromis nilotica) maintained in a recirculating\nsystem","volume":"38","author":"Michael","year":"2007","journal-title":"J. Zoo Wildl. Med."},{"issue":"17","key":"2026090104480976600_cit41","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/j.phytochem.2006.05.039","article-title":"Antiprotozoal\nand cytotoxic naphthalene derivatives from Diospyros assimilis","volume":"67","author":"Ganapaty","year":"2006","journal-title":"Phytochemistry"},{"issue":"2","key":"2026090104480976600_cit42","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301871","article-title":"Larvicidal activity against Spodoptera frugiperda of some constituents from two Diospyros species. In silico pesticide-likeness properties, acetylcholinesterase\nactivity and molecular docking","volume":"21","author":"Pe\u0301rez-Valera","year":"2024","journal-title":"Chem. Biodivers."},{"issue":"1","key":"2026090104480976600_cit43","doi-asserted-by":"publisher","first-page":"16046","DOI":"10.1038\/hortres.2016.46","article-title":"Biosynthesis and molecular\nactions of specialized 1,4-naphthoquinone\nnatural products produced by horticultural plants","volume":"3","author":"Widhalm","year":"2016","journal-title":"Horticult. Res."},{"issue":"4","key":"2026090104480976600_cit44","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1021\/np50076a009","article-title":"A Cytotoxic\nand antifungal 1,4-naphthoquinone\nand related compounds from a New Zealand brown alga, Landsburgia quercifolia","volume":"54","author":"Perry","year":"1991","journal-title":"J. Nat. Prod."},{"issue":"24","key":"2026090104480976600_cit45","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1021\/jo01312a019","article-title":"Electronic control\nof stereoselectivity. 6. Directionality of singlet oxygen addition\nto 1,4-dimethoxynaphthalenes laterally fused to bridged bicyclic systems","volume":"45","author":"Paquette","year":"1980","journal-title":"J. Org. Chem."},{"issue":"36","key":"2026090104480976600_cit46","doi-asserted-by":"publisher","first-page":"9697","DOI":"10.1021\/acs.jafc.0c03396","article-title":"2-Methoxy-1,4-naphthoquinone\nInduces Metabolic Shifts in Penicillium Digitatum Revealed by High-Dimensional Biological Data","volume":"68","author":"Guo","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"2026090104480976600_cit47","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1021\/acssuschemeng.7b00039","article-title":"Naphthoquinones\nfrom Walnut Husk\nResidues Show Strong Nematicidal Activities against the Root-knot\nNematode Meloidogyne hispanica","volume":"5","author":"Maleita","year":"2017","journal-title":"ACS Sustainable Chem. Eng."},{"issue":"21","key":"2026090104480976600_cit48","doi-asserted-by":"publisher","first-page":"6069","DOI":"10.1039\/D4QO01256A","article-title":"Herpotriquinones A and B, two dimeric\nnaphthoquinone\u2013epoxycyclohexenone\nadducts with anti-neuroinflammatory activity from the isopod-associated\nfungus Herpotrichia sp","volume":"11","author":"Zhai","year":"2024","journal-title":"SF09.\nOrg. Chem. Front."},{"issue":"2","key":"2026090104480976600_cit49","first-page":"253","article-title":"Antimalarial and antimycobacterial\nactivities of dimeric Naphthoquinone from Diospyros glandulosa and Diospyros rhodocalyx","volume":"6","author":"Theerachayanan","year":"2007","journal-title":"CMU. J. Nat. Sci."},{"issue":"47","key":"2026090104480976600_cit50","doi-asserted-by":"publisher","first-page":"26209","DOI":"10.1021\/acs.jafc.4c08652","article-title":"Naphthoquinone Derivatives from the\nEndophytic Fungus Fusarium solani Induce Pancreatic\nCancer Cells Apoptosis via Targeting EGFR-Mediated PI3K\/Akt Pathway","volume":"72","author":"Gao","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"2026090104480976600_cit51","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1021\/acs.jnatprod.6b00610","article-title":"Cytotoxic Naphthoquinone and Azaanthraquinone\nDerivatives\nfrom an Endophytic Fusarium solani","volume":"80","author":"Chowdhury","year":"2017","journal-title":"J. Nat. Prod."},{"key":"2026090104480976600_cit52","doi-asserted-by":"publisher","first-page":"101083","DOI":"10.1016\/j.crfs.2025.101083","article-title":"Antibacterial\nactivity and potential mechanisms of plumbagin against Escherichia coli and its application in milk","volume":"10","author":"Guo","year":"2025","journal-title":"Curr.\nRes. Food Sci."},{"key":"2026090104480976600_cit53","doi-asserted-by":"publisher","first-page":"114690","DOI":"10.1016\/j.biopha.2023.114690","article-title":"An overview on the\nantibacterial properties of juglone, naphthazarin, plumbagin and lawsone\nderivatives and their metal complexes","volume":"162","author":"Majdi","year":"2023","journal-title":"Biomed.\nPharmacother."},{"issue":"4","key":"2026090104480976600_cit54","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ijmm.2016.05.004","article-title":"Antimicrobial activity\nof plumbagin, a naturally occurring naphthoquinone from Plumbago rosea, against Staphylococcus aureus and Candida albicans","volume":"306","author":"Nair","year":"2016","journal-title":"Int. J. Med. Microbiol."},{"issue":"7","key":"2026090104480976600_cit55","doi-asserted-by":"publisher","first-page":"4126","DOI":"10.1021\/acs.jafc.4c12108","article-title":"Harnessing Functional Food Sources:\nDeriving Anti-Inflammatory and Antibacterial Naphthalene Derivatives\nfrom the Edible Bulbs of Eleutherine bulbosa","volume":"73","author":"Gao","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"13","key":"2026090104480976600_cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e43721","article-title":"1,4-Naphthoquinone analogues promote\ncross-protection to antibiotics through glutathione-dependent MexT-mediated\nMexEF-OprN expression in Pseudomonas aeruginosa","volume":"11","author":"Saninjuk","year":"2025","journal-title":"Heliyon"},{"issue":"5","key":"2026090104480976600_cit57","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/S1875-5364(25)60818-1","article-title":"Comprehensive analysis\nof the antibacterial activity\nof 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus","volume":"23","author":"Chen","year":"2025","journal-title":"Chin. J. Nat.\nMed."},{"key":"2026090104480976600_cit58","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.aquaculture.2019.01.024","article-title":"In vitro and in vivo screening of herbal extracts against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus)","volume":"503","author":"Guo","year":"2019","journal-title":"Aquaculture"},{"key":"2026090104480976600_cit59","doi-asserted-by":"publisher","first-page":"736778","DOI":"10.1016\/j.aquaculture.2021.736778","article-title":"The screen herbal immunopotentiator\nand research\non its effect on the innate immune system and disease resistance of\nNile tilapia (Oreochromis niloticus) against Streptococcus agalactiae","volume":"541","author":"Ding","year":"2021","journal-title":"Aquaculture"},{"key":"2026090104480976600_cit60","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.fsi.2022.06.032","article-title":"Effects\nof Elephantopus scaber extract on growth, proximate\ncomposition, immunity, intestinal microbiota\nand resistance of the GIFT strain of Nile tilapia Oreochromis niloticus to Streptococcus agalactiae","volume":"127","author":"Xu","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"2026090104480976600_cit61","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/ptr.1116","article-title":"In vitro cytotoxicity activity of\ndiosquinone, a naphthoquinone epoxide","volume":"17","author":"Adeniyi","year":"2003","journal-title":"Phytother.\nRes."},{"issue":"31","key":"2026090104480976600_cit62","doi-asserted-by":"publisher","first-page":"33888","DOI":"10.1021\/acsomega.4c03865","article-title":"Flavan-benzofurans\nfrom Artocarpus lacucha: Their intracellular antioxidant\nactivity and molecular docking to glutathione reductase","volume":"9","author":"Songoen","year":"2024","journal-title":"ACS Omega"}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c06920","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/33\/26332\/66533342\/acs.jafc.6c06920.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/33\/26332\/66533342\/acs.jafc.6c06920.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:48:17Z","timestamp":1788252497000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/33\/26332\/5254677\/Bioactive-Constituents-from-Roots-of-Diospyros"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":62,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2026,8,13]]},"published-print":{"date-parts":[[2026,8,26]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c06920","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}