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Although their pharmaceutical applications have been extensively reviewed, a comprehensive summary of their agrochemical uses is lacking. This review provides a concise overview of the synthetic approaches and structural modification strategies for furanones, systematically examines their structural diversity, and outlines their insecticidal, fungicidal, antiviral, herbicidal, and plant growth\u2013regulating activities. Additionally, the mechanisms of action of representative compounds are discussed in detail. Furthermore, this review highlights the potential of artificial intelligence\u2013based drug design, particularly for the discovery of novel, highly efficient, and ecofriendly structures. This review offers strategic perspectives for the future design and development of green, efficient furanone-based agrochemicals.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c07130","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:12:13Z","timestamp":1785849133000},"page":"23235-23260","source":"Crossref","is-referenced-by-count":0,"title":["Progress and Perspectives\nof Furanone Derivatives\nin Pesticide Chemistry"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4847-3541","authenticated-orcid":true,"given":"Yanqun","family":"Peng","sequence":"first","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-5320","authenticated-orcid":true,"given":"Luoman","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-7259","authenticated-orcid":true,"given":"Zengxue","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-371X","authenticated-orcid":true,"given":"Deyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8204-5939","authenticated-orcid":true,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for R&D of Fine Chemicals of Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"2","key":"2026080510104605900_cit1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.aac.2024.01.006","article-title":"Selectivin:\na nematicide from parasitic nematodes-specifically activated chemical","volume":"3","author":"Jiang","year":"2024","journal-title":"Adv. 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