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This study constructed an engineered strain, LG209, by overexpressing the transcriptional regulator OmpR, which significantly enhanced nematicidal activity against Meloidogyne incognita J2s and increased secondary metabolite production. From its fermentation broth, 20 compounds were isolated, including a new naphthoquinone derivative. Notably, phenylacetic acid (3), 2-(4-methoxyphenyl)acetic acid (5), and 9H-carbazole (18) exhibited strong nematicidal activity, with LC50 values of 52.34, 88.52, and 15.18 \u03bcg\/mL at 96 h, respectively. These compounds induced ROS burst and lipid peroxidation, leading to necrotic cell death in nematodes. Additionally, certain indole derivatives modulated nematode chemotaxis. In soil trials, LG209 fermentation broth achieved 68.9% control efficacy against root-knot nematode in tomato, surpassing the wild-type strain. This work provides a promising engineered strain and lead compounds for developing novel microbial nematicides.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c07342","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:27:29Z","timestamp":1784215649000},"page":"22919-22933","source":"Crossref","is-referenced-by-count":0,"title":["Harnessing\n                    <i>OmpR<\/i>\n                    for Enhanced Biocontrol:\nCharacterization of a Novel Engineered Strain of\n                    <i>Lysobacter gummosus<\/i>\n                    with Increased Nematicidal Properties"],"prefix":"10.1021","volume":"74","author":[{"given":"Yue-Yu","family":"Ma","sequence":"first","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Fan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, China, 650500"]},{"name":"Chuxiong Normal University , , ,","place":["Chuxiong, China, 675099"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4811-8430","authenticated-orcid":true,"given":"Guo-Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026072910072782500_cit1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/214321a0","article-title":"Carbohydrate nutrition of some nematode-trap ing-trapping\nfungi","volume":"214","author":"Satchuthananthavale","year":"1967","journal-title":"Nature"},{"key":"2026072910072782500_cit2","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.copbio.2021.06.010","article-title":"Biotechnological advances\nwith applicability in potatoes for resistance against root-knot nematodes","volume":"70","author":"Bali","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"key":"2026072910072782500_cit3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1146\/annurev-phyto-021621-120943","article-title":"Rooting out\nthe mechanisms of root-knot\nnematode-plant interactions","volume":"60","author":"Rutter","year":"2022","journal-title":"Annu. Rev. Phytopathol."},{"key":"2026072910072782500_cit4","doi-asserted-by":"publisher","first-page":"8672","DOI":"10.1021\/acs.jafc.8b01940","article-title":"Management of cyst and root knot\nnematodes: A chemical\necology perspective","volume":"66","author":"Torto","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"2026072910072782500_cit5","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1111\/pbi.14359","article-title":"Biochemical\nand nanotechnological approaches to combat phytoparasitic nematodes","volume":"22","author":"Opdensteinen","year":"2024","journal-title":"Plant Biotechnol. 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Prod."},{"key":"2026072910072782500_cit8","doi-asserted-by":"publisher","first-page":"142143","DOI":"10.1016\/j.chemosphere.2024.142143","article-title":"Exploiting\nfly ash as an ecofriendly pesticide\/nematicide on Abelmoschus esculentus: Insights into soil amendment-induced\nantioxidant fight against nematode mediated ROS","volume":"358","author":"Bhat","year":"2024","journal-title":"Chemosphere"},{"key":"2026072910072782500_cit9","doi-asserted-by":"publisher","first-page":"124561","DOI":"10.1016\/j.ijbiomac.2023.124561","article-title":"Preparation of enzyme-responsive\ncomposite nanocapsules with sodium carboxymethyl cellulose to improve\nthe control effect of root-knot nematode disease","volume":"241","author":"Pan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"2026072910072782500_cit10","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.soilbio.2008.03.011","article-title":"Biological control\nof the root-knot nematode Meloidogyne javanica by Trichoderma harzianum","volume":"40","author":"Sahebani","year":"2008","journal-title":"Soil Biol.\nand Biochem."},{"key":"2026072910072782500_cit11","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/nph.15953","article-title":"Strigolactones enhance root-knot\nnematode (Meloidogyne graminicola) infection in rice\nby antagonizing\nthe jasmonate pathway","volume":"224","author":"Lahari","year":"2019","journal-title":"New Phytol."},{"key":"2026072910072782500_cit12","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/nph.20220","article-title":"Cover crop rotation\nsuppresses root-knot nematode infection by shaping soil microbiota","volume":"245","author":"Zhang","year":"2025","journal-title":"New Phytol."},{"key":"2026072910072782500_cit13","doi-asserted-by":"publisher","first-page":"20763","DOI":"10.1021\/acs.jafc.4c01952","article-title":"Synergistic Effect\nof Two Peptaibols from Biocontrol\nFungus Trichoderma longibrachiatum Strain 40418 on\nCO-Induced Plant Resistance","volume":"72","author":"Luo","year":"2024","journal-title":"J. Agric. Food\nChem."},{"key":"2026072910072782500_cit14","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1039\/D2NP00074A","article-title":"Natural nematicidal\nmetabolites and advances in their\nbiocontrol capacity on plant parasitic nematodes","volume":"40","author":"Li","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"2026072910072782500_cit15","doi-asserted-by":"publisher","first-page":"20306","DOI":"10.1021\/ja3104044","article-title":"potent\nnematocidal PKS-NRPS hybrid metabolites from thermophilic fungus talaromyces\nthermophilus","volume":"134","author":"Guo","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"2026072910072782500_cit16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jare.2025.01.009","article-title":"Regulation\nof important natural products biosynthesis by WRKY transcription factors\nin plants","volume":"77","author":"Li","year":"2025","journal-title":"J. Adv. 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Microbiol."},{"key":"2026072910072782500_cit26","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1104\/pp.113.232025","article-title":"Pathway-level acceleration of glycogen\ncatabolism by a response regulator in the cyanobacterium Synechocystis species PCC 6803","volume":"164","author":"Osanai","year":"2014","journal-title":"Plant Physiol."},{"key":"2026072910072782500_cit27","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01192-20","article-title":"Roles of the EnvZ\/OmpR Two-Component System and Porins in Iron Acquisition\nin Escherichia coli","volume":"11","author":"Gerken","year":"2020","journal-title":"mBio"},{"key":"2026072910072782500_cit28","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/j.1365-2672.2009.04471.x","article-title":"Stenotrophomonas and Lysobacter: ubiquitous\nplant-associated gamma-proteobacteria of developing\nsignificance in applied\nmicrobiology","volume":"108","author":"Hayward","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"2026072910072782500_cit29","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1094\/PHYTO-07-23-0261-LE","article-title":"Metabolites from Lysobacter gummosus YMF3.00690\nAgainst Meloidogyne javanica","volume":"114","author":"Zhou","year":"2024","journal-title":"Phytopathology"},{"key":"2026072910072782500_cit30","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1021\/acs.jafc.4c08961","article-title":"3-Furoic Acid from\nSea-derived Aspergillus luchuensis Hy-6 as a valuable\nlead compound against plant-parasitic nematodes in Cucumber","volume":"73","author":"Wang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"2026072910072782500_cit31","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/s42003-021-02863-y","article-title":"Phosphorothioate-DNA bacterial diet\nreduces the ROS levels in C. elegans while improving\nlocomotion and longevity","volume":"4","author":"Huang","year":"2021","journal-title":"Commun. 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Total Environ."},{"key":"2026072910072782500_cit34","doi-asserted-by":"publisher","first-page":"31231","DOI":"10.1021\/acs.jafc.5c12752","article-title":"DhTmp1, a Zn(II)2Cys6 transcription\nfactor, negatively regulates pathogenicity in Dactylellina haptotyla by repressing nematicidal metabolite biosynthesis","volume":"73","author":"Lei","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"2026072910072782500_cit35","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1093\/oxfordjournals.jbchem.a002863","article-title":"The OmpR-family of proteins: insight into the tertiary\nstructure and functions of two-component regulator proteins","volume":"129","author":"Itou","year":"2001","journal-title":"J. Biochem."},{"key":"2026072910072782500_cit36","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1038\/s41467-025-56697-x","article-title":"Structural insights into transcription\nregulation of the global OmpR\/PhoB family regulator PhoP from Mycobacterium tuberculosis","volume":"16","author":"Shi","year":"2025","journal-title":"Nat. Commun."},{"key":"2026072910072782500_cit37","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/j.1574-6976.2009.00204.x","article-title":"Indole as an intercellular\nsignal in microbial communities","volume":"34","author":"Lee","year":"2010","journal-title":"FEMS Microbiol.\nRev."},{"key":"2026072910072782500_cit38","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01896-23","article-title":"2-Furoic acid associated\nwith the infection of nematodes by Dactylellina haptotyla and its biocontrol potential on plant root-knot nematodes","volume":"11","author":"Lei","year":"2023","journal-title":"Microbiol. 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