{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:54:02Z","timestamp":1791982442082,"version":"4.4.0"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["32502379"],"award-info":[{"award-number":["32502379"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1104601-05"],"award-info":[{"award-number":["2023YFF1104601-05"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["32025030"],"award-info":[{"award-number":["32025030"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Environmental mycotoxins threaten human and animal health. Deoxynivalenol (DON) and emerging tenuazonic acid (TeA) severely contaminate food crops. The intestine is DON\u2019s main toxic target and TeA\u2019s primary exposure site, but TeA\u2019s intestinal risk and their combined toxicity remain understudied. In this study, using an intestinal organoid model, we found that DON and TeA significantly suppressed cell viability (toxicity ratio \u223c 1:20) with synergistic effects under high toxicity, disrupting organoid development and intestinal barrier function (cell cycle arrest, reduced tight junction proteins, increased goblet cells), linked to their ribotoxicity and inducing lipid metabolism disorders (downregulated fatty acid \u03b2-oxidation genes) via the PPAR pathway. Single-cell transcriptome revealed that they impaired intestinal cell proliferation\/differentiation, inducing ribotoxic stress in stem\/TA cells and reducing canonical enterocytes (ECs), and ECs were core targets of their lipid toxicity. In conclusion, DON and TeA share intestinal toxicological characteristics, and their combined exposure potentiates toxicity, requiring targeted measures to mitigate co-exposure risks.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c07522","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:02:26Z","timestamp":1790704946000},"page":"31840-31857","source":"Crossref","is-referenced-by-count":0,"title":["Intestinal Organoid-Based Toxicity Study on Co-exposure\nto Food Contaminants Deoxynivalenol and Tenuazonic Acid"],"prefix":"10.1021","volume":"74","author":[{"given":"Huikang","family":"Lin","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhe","family":"Chang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhu","family":"Tan","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-8644","authenticated-orcid":true,"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-1592","authenticated-orcid":true,"given":"Aibo","family":"Wu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200031"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"33","key":"2026101408095906800_cit1","doi-asserted-by":"publisher","first-page":"7052","DOI":"10.1021\/acs.jafc.6b03413","article-title":"Emerging Mycotoxins:\nBeyond Traditionally Determined Food Contaminants","volume":"65","author":"Gruber-Dorninger","year":"2017","journal-title":"J. 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Nutr."},{"key":"2026101408095906800_cit4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.fochx.2025.102350","article-title":"Mycotoxins: A comprehensive review\nof its global trends in major\ncereals, advancements in chromatographic detections and future prospectives","author":"Niaz","year":"2025","journal-title":"Food Chem.:X"},{"issue":"15","key":"2026101408095906800_cit5","doi-asserted-by":"publisher","first-page":"5602","DOI":"10.3390\/ijerph17155602","article-title":"Assessment of Deoxynivalenol in Wheat,\nCorn and Its Products and Estimation of Dietary Intake","volume":"17","author":"Iqbal","year":"2020","journal-title":"Int. J. Environ. Res. 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