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Depending on their amino acid composition, physicochemical properties, and assembly state, some FDBPs may interact directly with cellular membranes and modulate lipid organization. Membrane phase separation provides an emerging biophysical framework for interpreting the actions of FDBPs. This review presents a prospective analysis of FDBP-membrane phase interactions, emphasizing available research methods, biological contexts, and structure\u2013activity relationships. In particular, we examine how peptide localization, charged and hydrophobic residues, chemical modification, and multivalent assembly may influence membrane fluidity, thickness, surface charge, and the organization of liquid-ordered and liquid-disordered domains. This perspective has the potential to broaden the mechanistic understanding of FDBPs\u2019 bioactivities and to guide the rational design of membrane-targeted functional foods.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c07756","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:01:52Z","timestamp":1786359712000},"page":"24879-24897","source":"Crossref","is-referenced-by-count":0,"title":["Membrane Phase Separation: An Emerging Biophysical\nPerspective on Food-Derived Bioactive Peptides"],"prefix":"10.1021","volume":"74","author":[{"given":"Haofei","family":"Du","sequence":"first","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-6332","authenticated-orcid":true,"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Ye","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-5494","authenticated-orcid":true,"given":"Zhipeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-7074","authenticated-orcid":true,"given":"Yiding","family":"Yu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026081910161008000_cit1","doi-asserted-by":"publisher","first-page":"104896","DOI":"10.1016\/j.tifs.2025.104896","article-title":"Food-derived bioactive peptides: The gateway to reach\nthe full potential of food proteins for human health","volume":"157","author":"Fernando","year":"2025","journal-title":"Trends Food Sci. 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