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In this study, Klebsiella pneumoniae HNGD-HS06 was isolated from contaminated peanuts and degraded aflatoxin B1 (AFB1), zearalenone (ZEN), and alternariol (AOH) by 72.52%, 63.42%, and 76.17%, respectively. Genome-guided screening and heterologous expression identified two candidate proteins, HSFtsp and HSCueO. HSCueO shared only 28.08% sequence identity with CotA laccase, while HSFtsp has not previously been associated with mycotoxin degradation. HSFtsp degraded AFB1, ZEN, and AOH by up to 99.16%, 95.12%, and 94.72%, respectively, whereas HSCueO achieved 98.97%, 99.23%, and 99.74% degradation. Product analysis and zebrafish assays suggested that both enzymes transformed these toxins into less toxic products, while molecular docking supported potential enzyme\u2013substrate interactions. Both enzymes retained detoxification activity in contaminated peanut, corn, and wheat flour, expanding enzyme resources for multimycotoxin control in foods.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c07866","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:17:27Z","timestamp":1785140247000},"page":"23839-23857","source":"Crossref","is-referenced-by-count":0,"title":["Identification\nand Characterization of Two Multimycotoxin\nDegrading Enzymes from\n                    <i>Klebsiella pneumoniae<\/i>\n                    HNGD-HS06"],"prefix":"10.1021","volume":"74","author":[{"given":"Minjie","family":"Hou","sequence":"first","affiliation":[{"name":"Henan University of Technology , , ,","place":["Zhengzhou, P. R. China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhong","family":"Chang","sequence":"additional","affiliation":[{"name":"Henan University of Technology , , ,","place":["Zhengzhou, P. R. 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