{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:18:13Z","timestamp":1788254293215,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100008054","name":"Fundaci?n Ram?n Areces","doi-asserted-by":"publisher","award":["RYC2020-030365-I"],"award-info":[{"award-number":["RYC2020-030365-I"]}],"id":[{"id":"10.13039\/100008054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci?n y Universidades","doi-asserted-by":"publisher","award":["IJC2020-046055-I"],"award-info":[{"award-number":["IJC2020-046055-I"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED431F2022\/01"],"award-info":[{"award-number":["ED431F2022\/01"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) is a highly sophisticated disease associated with mitochondrial deterioration, which potentiates proteotoxic stress and accelerates neuronal decline. Vitamin B12 (B12), an essential cofactor in one-carbon metabolism and cellular homeostasis, plays a pivotal role in modulating neurodegenerative pathology. Here, we established a mitochondrial-associated AD model by using Caenorhabditis elegans (C. elegans) expressing A\u03b2 combining with the mtDNA deletion uaDf5, and evaluated the effect of B12 as a metabolic modulator of neurodegenerative stress. We observed that mitochondrial dysfunction markedly exacerbated A\u03b2 phenotypes, while B12 mitigated paralysis and cellular deficits. Integrated transcriptomics and proteomics revealed a compensatory mechanism activated by B12 under mitochondrial stress, predominantly engaging one-carbon and transsulfuration pathways. Functional analyses uncovered that metr-1 and cysl-2 are required for B12-mediated protection, and multiomics corroborated this rescue axis. This study indicates that cysl-2 is an essential mediator and reveals a B12-driven adaptive response, which provides mechanistic insight into nutrition-based neuroprotection in AD.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c07935","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:02:11Z","timestamp":1786644131000},"page":"26389-26400","source":"Crossref","is-referenced-by-count":0,"title":["Identification of\n                    <i>Cysl-2<\/i>\n                    as\na Compensatory Factor in Vitamin B12-Mediated Protection in a Mitochondrial\nA\u03b2 Toxicity Model"],"prefix":"10.1021","volume":"74","author":[{"given":"Qihui","family":"Huang","sequence":"first","affiliation":[{"name":"Universidade de Vigo , , ,","place":["Vigo, Spain, 36310"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Fu","sequence":"additional","affiliation":[{"name":"Fujian Agriculture and Forestry University , , ,","place":["Fuzhou, China, 350002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 200240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Yao","sequence":"additional","affiliation":[{"name":"Fujian Agriculture and Forestry University , , ,","place":["Fuzhou, China, 350002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-4734","authenticated-orcid":true,"given":"Hui","family":"Cao","sequence":"additional","affiliation":[{"name":"Universidade de Vigo , , ,","place":["Vigo, Spain, 36310"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3350-8498","authenticated-orcid":true,"given":"Lingjun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 200240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-632X","authenticated-orcid":true,"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fujian Agriculture and Forestry University , , ,","place":["Fuzhou, China, 350002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-770X","authenticated-orcid":true,"given":"Jianbo","family":"Xiao","sequence":"additional","affiliation":[{"name":"Universidade de Vigo , , ,","place":["Vigo, Spain, 36310"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"10","key":"2026090104474769100_cit1","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-beta and tau in Alzheimer\u2019s\ndisease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"4","key":"2026090104474769100_cit2","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.3233\/JAD-215139","article-title":"Synaptic mitochondria:\nan early target of amyloid-\u03b2 and tau in Alzheimer\u2019s disease","volume":"84","author":"Torres","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"2026090104474769100_cit3","doi-asserted-by":"publisher","first-page":"102713","DOI":"10.1016\/j.arr.2025.102713","article-title":"Mitochondrial\ndysfunction in Alzheimer\u2019s disease","volume":"107","author":"D\u2019Alessandro","year":"2025","journal-title":"Ageing\nRes. Rev."},{"key":"2026090104474769100_cit4","doi-asserted-by":"publisher","first-page":"1517965","DOI":"10.3389\/fnagi.2024.1517965","article-title":"Mitochondrial dysfunction\nand Alzheimer\u2019s disease: pathogenesis of mitochondrial transfer","volume":"16","author":"Wei","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"2026090104474769100_cit5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.copbio.2019.12.011","article-title":"Caenorhabditis elegans as a model\nsystem for human diseases","volume":"63","author":"Markaki","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"issue":"7","key":"2026090104474769100_cit6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219486","article-title":"Caenorhabditis elegans hub genes that respond to amyloid beta are homologs\nof genes involved\nin human Alzheimer\u2019s disease","volume":"14","author":"Godini","year":"2019","journal-title":"PLoS One"},{"issue":"12","key":"2026090104474769100_cit7","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1021\/acschemneuro.7b00361","article-title":"Genetic and Pharmacological\nDiscovery\nfor Alzheimer\u2019s Disease Using Caenorhabditis elegans","volume":"8","author":"Griffin","year":"2017","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"2026090104474769100_cit8","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13024-023-00664-x","article-title":"Simple model systems\nreveal conserved mechanisms of\nAlzheimer\u2019s disease and related tauopathies","volume":"18","author":"Jiang","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"6","key":"2026090104474769100_cit9","doi-asserted-by":"publisher","first-page":"955","DOI":"10.4103\/1673-5374.233432","article-title":"Natural polyphenols\neffects on protein aggregates in Alzheimer\u2019s and Parkinson\u2019s\nprion-like diseases","volume":"13","author":"Freyssin","year":"2018","journal-title":"Neural Regener. Res."},{"issue":"3","key":"2026090104474769100_cit10","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1002\/alz.12845","article-title":"Nutritional metabolism\nand cerebral bioenergetics in Alzheimer\u2019s disease and related\ndementias","volume":"19","author":"Yassine","year":"2023","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026090104474769100_cit11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60259","article-title":"Caenorhabditis elegans methionine\/S-adenosylmethionine cycle\nactivity is sensed and adjusted\nby a nuclear hormone receptor","volume":"9","author":"Giese","year":"2020","journal-title":"Elife"},{"issue":"1","key":"2026090104474769100_cit12","doi-asserted-by":"publisher","first-page":"17602","DOI":"10.1038\/s41598-019-54070-9","article-title":"Effect of imbalance in folate and\nvitamin B12 in maternal\/parental\ndiet on global methylation and regulatory miRNAs","volume":"9","author":"Mahajan","year":"2019","journal-title":"Sci. Rep."},{"issue":"11","key":"2026090104474769100_cit13","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1038\/s42255-023-00916-6","article-title":"Vitamin\nB(12) is a limiting\nfactor for induced cellular plasticity and tissue repair","volume":"5","author":"Kovatcheva","year":"2023","journal-title":"Nat. Metab."},{"key":"2026090104474769100_cit14","doi-asserted-by":"publisher","first-page":"106201","DOI":"10.1016\/j.ejps.2022.106201","article-title":"Vitamin B12 as a cholinergic system\nmodulator and blood brain barrier integrity restorer in Alzheimer\u2019s\ndisease","volume":"174","author":"El-Mezayen","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"issue":"17","key":"2026090104474769100_cit15","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500808","article-title":"Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine-Type\nStimulants: A Novel Approach to Evaluating New Psychoactive Substances\nActivity and Mechanisms","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"issue":"48","key":"2026090104474769100_cit16","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202502486","article-title":"Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation\nof Liquid\u2013Liquid Phase Separation in Caenorhabditis elegans","volume":"12","author":"Luo","year":"2025","journal-title":"Adv. Sci."},{"issue":"36","key":"2026090104474769100_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202400879","article-title":"ROF-2 as an Aggregation-Induced\nEmission\n(AIE) Probe for Multi-Target Amyloid Detection and Screening of Amyloid\nInhibitors","volume":"20","author":"Tang","year":"2024","journal-title":"Small"},{"issue":"1","key":"2026090104474769100_cit18","doi-asserted-by":"publisher","first-page":"6879","DOI":"10.1038\/s41467-024-51069-3","article-title":"Optogenetic induction\nof mechanical\nmuscle stress identifies myosin regulatory ubiquitin ligase NHL-1\nin C. elegans","volume":"15","author":"Kutzner","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"2026090104474769100_cit19","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1038\/s41467-024-46037-w","article-title":"Reducing the metabolic\nburden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans","volume":"15","author":"Sharifi","year":"2024","journal-title":"Nat. Commun."},{"key":"2026090104474769100_cit20","doi-asserted-by":"publisher","first-page":"101939","DOI":"10.1016\/j.fbio.2022.101939","article-title":"Polygonatum sibiricum polysaccharide extract relieves FB1-induced neurotoxicity\nby reducing oxidative stress and mitochondrial damage in Caenorhabditis elegans","volume":"49","author":"Zhang","year":"2022","journal-title":"Food Biosci."},{"issue":"2","key":"2026090104474769100_cit21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s43587-022-00340-7","article-title":"Optogenetic\nrejuvenation of mitochondrial membrane potential extends C. elegans lifespan","volume":"3","author":"Berry","year":"2023","journal-title":"Nat. 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Hazard.\nMater."},{"issue":"23","key":"2026090104474769100_cit23","doi-asserted-by":"publisher","first-page":"14290","DOI":"10.1039\/D4NR04227A","article-title":"Mitochondrial\ndamage and reactive\noxygen species production in C. elegans: key factors in CdTe\/ZnS quantum\ndot-Cet probes","volume":"17","author":"Hu","year":"2025","journal-title":"Nanoscale"},{"issue":"8","key":"2026090104474769100_cit24","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1080\/15548627.2025.2482724","article-title":"T16G12.6\/IMPORTIN\n13-mediated cytoplasm-to-nucleus\ntransport of the THAP transcription factor LIN-15B controls autophagy\nand lysosome function in C. elegans","volume":"21","author":"Ma","year":"2025","journal-title":"Autophagy"},{"key":"2026090104474769100_cit25","doi-asserted-by":"publisher","first-page":"155463","DOI":"10.1016\/j.phymed.2024.155463","article-title":"Penthorum chinense Pursh inhibits ferroptosis in\ncellular and Caenorhabditis elegans models of Alzheimer\u2019s\ndisease","volume":"127","author":"Yong","year":"2024","journal-title":"Phytomedicine"},{"issue":"32","key":"2026090104474769100_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301527","article-title":"Noninvasive Treatment\nof Alzheimer\u2019s Disease\nwith Scintillating Nanotubes","volume":"12","author":"Senapati","year":"2023","journal-title":"Adv. Healthcare\nMater."},{"issue":"25","key":"2026090104474769100_cit27","doi-asserted-by":"publisher","first-page":"14315","DOI":"10.1021\/acs.jafc.3c09583","article-title":"EGCG Alleviates the Aging Toxicity\nInduced by 3-MCPD via IIS Pathway in Caenorhabditis elegans with Abnormal Reproduction and Heat Shock Protein","volume":"72","author":"Liu","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"19","key":"2026090104474769100_cit28","doi-asserted-by":"publisher","first-page":"9849","DOI":"10.1039\/D4FO02271H","article-title":"Physiological\nevaluation and transcriptomic and proteomic analyses to reveal the\nanti-aging and reproduction-promoting mechanisms of glycitein in Caenorhabditis elegans","volume":"15","author":"Lei","year":"2024","journal-title":"Food Funct."},{"issue":"4","key":"2026090104474769100_cit29","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1039\/D4FO03636K","article-title":"Causal relationship\nbetween dietary habits and Alzheimer\u2019s\ndisease risk: a univariable and multivariable Mendelian randomization\nstudy","volume":"16","author":"Huang","year":"2025","journal-title":"Food Funct."},{"key":"2026090104474769100_cit30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.7554\/eLife.70382","article-title":"GWAS and ExWAS of blood mitochondrial DNA copy number\nidentifies 71 loci and highlights a potential causal role in dementia","volume":"11","author":"Chong","year":"2022","journal-title":"Elife"},{"issue":"2","key":"2026090104474769100_cit31","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s12035-012-8251-3","article-title":"Abeta toxicity in Alzheimer\u2019s\ndisease","volume":"45","author":"Cavallucci","year":"2012","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"2026090104474769100_cit32","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria\nin oxidative stress,\ninflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"issue":"12","key":"2026090104474769100_cit33","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1021\/acschemneuro.7b00229","article-title":"Multifunctional\nAnalogs of Kynurenic Acid for the Treatment of Alzheimer\u2019s\nDisease: Synthesis, Pharmacology, and Molecular Modeling Studies","volume":"8","author":"Deora","year":"2017","journal-title":"ACS Chem. Neurosci."},{"issue":"7684","key":"2026090104474769100_cit34","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature25143","article-title":"Enhancing mitochondrial proteostasis reduces amyloid-\u03b2\nproteotoxicity","volume":"552","author":"Sorrentino","year":"2017","journal-title":"Nature"},{"key":"2026090104474769100_cit35","doi-asserted-by":"publisher","first-page":"101702","DOI":"10.1016\/j.arr.2022.101702","article-title":"The mitochondrial unfolded protein\nresponse: A multitasking giant in the fight against human diseases","volume":"81","author":"Zhou","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"7","key":"2026090104474769100_cit36","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.tcb.2013.02.002","article-title":"Evaluating and responding to mitochondrial\ndysfunction: the mitochondrial unfolded-protein response and beyond","volume":"23","author":"Haynes","year":"2013","journal-title":"Trends Cell Biol."},{"issue":"1","key":"2026090104474769100_cit37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/1028415X.2021.2009993","article-title":"Chlorogenic acid delays\nthe progression of Parkinson\u2019s\ndisease via autophagy induction in Caenorhabditis elegans","volume":"26","author":"He","year":"2023","journal-title":"Nutr. Neurosci."},{"issue":"3","key":"2026090104474769100_cit38","doi-asserted-by":"publisher","first-page":"113865","DOI":"10.1016\/j.celrep.2024.113865","article-title":"Metabolic rescue of\n\u03b1-synuclein-induced neurodegeneration through propionate supplementation\nand intestine-neuron signaling in C. elegans","volume":"43","author":"Wang","year":"2024","journal-title":"Cell Rep."},{"issue":"1\u20132","key":"2026090104474769100_cit39","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.cell.2014.11.048","article-title":"Endogenous hydrogen sulfide production is essential for dietary restriction\nbenefits","volume":"160","author":"Hine","year":"2015","journal-title":"Cell"},{"issue":"1","key":"2026090104474769100_cit40","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70014","article-title":"Mitochondrial DNA (mtDNA)\nas fluid biomarker in neurodegenerative\ndisorders: A systematic review","volume":"32","author":"Risi","year":"2025","journal-title":"Eur. J. Neurol."},{"issue":"8","key":"2026090104474769100_cit41","doi-asserted-by":"publisher","first-page":"4527","DOI":"10.1039\/D3FO05756A","article-title":"The causal association\nbetween artificial sweeteners\nand the risk of cancer: a Mendelian randomization study","volume":"15","author":"Pan","year":"2024","journal-title":"Food Funct."},{"issue":"21","key":"2026090104474769100_cit42","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.3969\/j.issn.1673-5374.2013.21.009","article-title":"Oxidative stress, mitochondrial damage\nand neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regener.\nRes."},{"issue":"1","key":"2026090104474769100_cit43","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/alz.12683","article-title":"The role\nof mitochondrial dysfunction\nin Alzheimer\u2019s disease pathogenesis","volume":"19","author":"Ashleigh","year":"2023","journal-title":"Alzheimer\u2019s Dementia"},{"issue":"3","key":"2026090104474769100_cit44","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.gendis.2016.05.001","article-title":"Mitochondria as\na therapeutic target in Alzheimer\u2019s\ndisease","volume":"3","author":"Wang","year":"2016","journal-title":"Genes Dis."},{"issue":"3","key":"2026090104474769100_cit45","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative\nstress, dysfunctional glucose metabolism\nand Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"11","key":"2026090104474769100_cit46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080135","article-title":"C. elegans aging is modulated by hydrogen\nsulfide and the sulfhydrylase\/cysteine synthase cysl-2","volume":"8","author":"Qabazard","year":"2013","journal-title":"PLoS One"},{"issue":"22","key":"2026090104474769100_cit47","doi-asserted-by":"publisher","first-page":"4941","DOI":"10.1016\/j.cub.2022.09.041","article-title":"Co-opted genes of\nalgal origin protect C. elegans against cyanogenic\ntoxins","volume":"32","author":"Wang","year":"2022","journal-title":"Curr. Biol."},{"issue":"1","key":"2026090104474769100_cit48","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1038\/s41467-020-15555-8","article-title":"Cysteine\nsynthases CYSL-1 and CYSL-2\nmediate C. elegans heritable adaptation to P. vranovensis infection","volume":"11","author":"Burton","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"2026090104474769100_cit49","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.cell.2024.11.026","article-title":"Perception of a pathogenic signature\ninitiates intergenerational\nprotection","volume":"188","author":"Pender","year":"2025","journal-title":"Cell"},{"key":"2026090104474769100_cit50","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2022.05.005","article-title":"Cysteine\nmetabolism and hydrogen sulfide signaling in Huntington\u2019s disease","volume":"186","author":"Paul","year":"2022","journal-title":"Free Rad. Biol. Med."},{"key":"2026090104474769100_cit51","doi-asserted-by":"publisher","first-page":"102958","DOI":"10.1016\/j.redox.2023.102958","article-title":"A role\nfor the cystathionine-beta-synthase\/H2S axis in astrocyte\ndysfunction in the aging brain","volume":"68","author":"Dey","year":"2023","journal-title":"Redox Biol."},{"key":"2026090104474769100_cit52","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.redox.2016.10.013","article-title":"Vitamin B(12) deficiency\nresults in severe oxidative\nstress, leading to memory retention impairment in Caenorhabditis elegans","volume":"11","author":"Bito","year":"2017","journal-title":"Redox Biol."},{"issue":"2","key":"2026090104474769100_cit53","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1007\/s12035-016-9736-2","article-title":"Oxidative Stress\nMarkers in Vitamin B12 Deficiency","volume":"54","author":"Misra","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"2026090104474769100_cit54","doi-asserted-by":"publisher","first-page":"6665","DOI":"10.1039\/D1FO03574F","article-title":"Are micronutrient\nlevels and supplements causally associated with the risk of Alzheimer\u2019s\ndisease? 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