{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:43:23Z","timestamp":1792784603021,"version":"4.5.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472297"],"award-info":[{"award-number":["32472297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20735"],"award-info":[{"award-number":["U25A20735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province","id":[{"id":"https:\/\/ror.org\/01cvdks57","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Urolithins, gut microbiota-derived metabolites of ellagic acid, demonstrate potential in mitigating aging-related physiological decline. This study investigated the neuroprotective effects and mechanisms of pomegranate juice fermented with Lactiplantibacillus plantarum CCFM1286 (CCFM1286FPJ) in mice with D-galactose-induced brain aging. CCFM1286FPJ intervention significantly improved aging-related anxiety-like behaviors, attenuated hippocampal neuronal damage, and lowered systemic inflammation. Mechanistically, CCFM1286FPJ suppressed glial activation, thereby inhibiting p53\/p21 and p16 senescence-associated pathways and restoring BAX\/Bcl-2 balance to suppress caspase-3-dependent apoptosis. Furthermore, CCFM1286FPJ promoted autophagy and induced PINK1\/Parkin-mediated mitophagy. Serum metabolomics revealed the enrichment of pomegranate-specific metabolites, including punicic acid and urolithins, and identified modulation of tryptophan metabolism and the tricarboxylic acid cycle, implicating these pathways in the amelioration of neuroinflammation and the restoration of energy homeostasis. These results indicate that CCFM1286FPJ counteracts brain aging, potentially through multiple mechanisms involving fermentation-derived bioactives.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08050","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:02:14Z","timestamp":1790359334000},"page":"30817-30825","source":"Crossref","is-referenced-by-count":0,"title":["Fermented Pomegranate\nJuice with\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    CCFM1286 Attenuates Brain Aging in Association\nwith PINK1\/Parkin Activation"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8598-2747","authenticated-orcid":true,"given":"Mengwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. 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R China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-0799","authenticated-orcid":true,"given":"Jianxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-4710","authenticated-orcid":true,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3559-2332","authenticated-orcid":true,"given":"Shumao","family":"Cui","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, P. R China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026100711063225000_cit1","unstructured":"World Health Organization.\n          \n          Ageing and health. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ageing-and-health (accessed Mar 22 2026)."},{"key":"2026100711063225000_cit2","doi-asserted-by":"publisher","first-page":"102141","DOI":"10.1016\/j.arr.2023.102141","article-title":"Cellular senescence\nin brain aging and neurodegeneration","volume":"93","author":"Melo dos Santos","year":"2024","journal-title":"Ageing\nRes. Rev."},{"issue":"1","key":"2026100711063225000_cit3","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1038\/s41467-024-47840-1","article-title":"Inflammation\nand mitophagy are mitochondrial\ncheckpoints to aging","volume":"15","author":"Guilbaud","year":"2024","journal-title":"Nat. Commun."},{"issue":"6703","key":"2026100711063225000_cit4","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1126\/science.adi3450","article-title":"Neuronal senescence\nmay drive brain\naging","volume":"384","author":"Herdy","year":"2024","journal-title":"Science"},{"issue":"1","key":"2026100711063225000_cit5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/15548627.2024.2414461","article-title":"Mitophagy\nas a guardian against cellular aging","volume":"21","author":"Kataura","year":"2025","journal-title":"Autophagy"},{"issue":"4","key":"2026100711063225000_cit6","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41573-024-01105-0","article-title":"Targeting\nmitophagy in neurodegenerative diseases","volume":"24","author":"Antico","year":"2025","journal-title":"Nat.\nRev. 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Neurosci."},{"issue":"8","key":"2026100711063225000_cit13","doi-asserted-by":"publisher","first-page":"4100","DOI":"10.1039\/C8FO00956B","article-title":"The gut\nmicrobiota urolithin metabotypes revisited: the human metabolism of\nellagic acid is mainly determined by aging","volume":"9","author":"Corte\u0301s-Marti\u0301n","year":"2018","journal-title":"Food Funct."},{"issue":"1","key":"2026100711063225000_cit14","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s40168-021-01108-8","article-title":"Human gut-derived B.\nlongum subsp. longum strains protect against aging in a d-galactose-induced\naging mouse model","volume":"9","author":"Xiao","year":"2021","journal-title":"Microbiome"},{"issue":"19","key":"2026100711063225000_cit15","doi-asserted-by":"publisher","first-page":"11477","DOI":"10.1021\/acs.jafc.5c00634","article-title":"Appeal of Urolithins from Synthesis\nto Biological Activities","volume":"73","author":"Xu","year":"2025","journal-title":"J. Agric. 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Food Chem."},{"key":"2026100711063225000_cit18","doi-asserted-by":"publisher","first-page":"143033","DOI":"10.1016\/j.ijbiomac.2025.143033","article-title":"Lactoferrin ameliorates cognitive\nimpairment in D-galactose-induced aging mice by regulating the PI3K\/Akt\/mTOR\nsignaling pathway and the microbiome-gut-brain axis","volume":"309","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"2026100711063225000_cit19","unstructured":"Pomegranate juice. https:\/\/www.foodwake.cn\/food\/1071 (accessed November 19, 2025)."},{"issue":"4","key":"2026100711063225000_cit20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and\nage-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. 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