{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:05:33Z","timestamp":1789567533851,"version":"build-2803163510"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472336"],"award-info":[{"award-number":["32472336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Large lipid droplets (LDs) resist lipophagy-mediated degradation due to steric hindrance, contributing to hepatic lipid accumulation in nonalcoholic fatty liver disease (NAFLD). Apigenin (API), a flavonoid abundant in fruits and vegetables, improves NAFLD, but its mechanism remains unclear. In this study, we found that API notably reduced LD size, thereby facilitating subsequent lipophagy. Transcriptomic analysis and validation revealed that API downregulated cell death-inducing DFF45-like effector C (CIDEC), a key promoter of LD fusion. Mechanistically, API suppressed CIDEC transcription by inhibiting four and a half LIM domains protein 2 (FHL2)-dependent nuclear translocation of peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3). Network pharmacology identified the Phosphatidylinositol 3-Kinase-Protein Kinase B (PI3K-AKT) pathway as a potential regulatory pathway. SC79-mediated AKT activation reversed API-induced LD size reduction and lipophagy enhancement. Collectively, API suppressed CIDEC expression through the AKT-FHL2\/PPAR\u03b3 pathway, thereby limiting LD fusion and creating better conditions for lipophagy, providing novel dietary intervention strategies for NAFLD.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08297","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:19:06Z","timestamp":1788466746000},"page":"28775-28794","source":"Crossref","is-referenced-by-count":0,"title":["Apigenin Enhances\nHepatic Lipophagy through Regulating\nLipid Droplet Size via the AKT-FHL2\/PPAR\u03b3-CIDEC Pathway"],"prefix":"10.1021","volume":"74","author":[{"given":"Yuelin","family":"Chen","sequence":"first","affiliation":[{"name":"Jilin University , , , ,","place":["Changchun, Jilin, People\u2019s Republic of China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhu","family":"Feng","sequence":"additional","affiliation":[{"name":"Jilin University , , , ,","place":["Changchun, Jilin, People\u2019s Republic of China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-167X","authenticated-orcid":true,"given":"Shuang","family":"Guan","sequence":"additional","affiliation":[{"name":"Jilin University , , , ,","place":["Changchun, Jilin, People\u2019s Republic of China, 130062"]},{"name":"Jilin University , , ,","place":["Changchun, People\u2019s Republic of China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jilin University , , , ,","place":["Changchun, Jilin, People\u2019s Republic of China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxian","family":"Jia","sequence":"additional","affiliation":[{"name":"Jilin University , , , ,","place":["Changchun, Jilin, People\u2019s Republic of China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxi","family":"Lang","sequence":"additional","affiliation":[{"name":"Jilin University , , , ,","place":["Changchun, Jilin, People\u2019s Republic of China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-3082","authenticated-orcid":true,"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Jilin University , , , ,","place":["Changchun, Jilin, People\u2019s Republic of China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"issue":"10481","key":"2026091609093223600_cit1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S0140-6736(25)00397-6","article-title":"Global,\nRegional, and National Prevalence of Child and Adolescent Overweight\nand Obesity, 1990\u20132021, with Forecasts to 2050: A Forecasting\nStudy for the Global Burden of Disease Study 2021","volume":"405","author":"GBD 2021 Adolescent BMI Collaborators","year":"2025","journal-title":"Lancet"},{"issue":"4","key":"2026091609093223600_cit2","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1039\/D6CB00081A","article-title":"Lipid Droplet Dynamics in Metabolic\nRegulation","volume":"7","author":"Weiskirchen","year":"2026","journal-title":"RSC Chem. 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