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Results showed that FBTB intervention ameliorated metabolic disorders, suppressed jejunal lipid accumulation, and enhanced fecal lipid excretion. 16S rRNA gene sequencing demonstrated that FBTB reversed gut microbiota dysbiosis and increased the abundance of potentially beneficial genera such as Dubosiella and Lactobacillus. Metabolomics revealed that FBTB altered tryptophan metabolism and significantly increased cecal levels of indole-3-acetic acid (IAA) and indole-3-propionic acid (IPA). Furthermore, these metabolites activated jejunal aryl hydrocarbon receptor (AhR) and interleukin-22 (IL-22) signaling, subsequently downregulating lipid transporters FATP4 and CD36 to reduce jejunal lipid accumulation. Notably, antibiotic treatment significantly blunted the suppressive effect of FBTB on jejunal lipid accumulation. Overall, FBTB prevents obesity may be through modulating the gut microbiota-tryptophan-IL-22 axis to reduce intestinal lipid accumulation.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08340","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:02:51Z","timestamp":1785934971000},"page":"24437-24456","source":"Crossref","is-referenced-by-count":0,"title":["Theabrownin from\nFu Brick Tea Ameliorates Obesity\nvia Modulating Tryptophan Metabolism and Downregulating Intestinal\nLipid Transporters"],"prefix":"10.1021","volume":"74","author":[{"given":"Jiaxue","family":"Li","sequence":"first","affiliation":[{"name":"Shaanxi Normal University , , ,","place":["Xi\u2019an, China, 710119"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4957-6014","authenticated-orcid":true,"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Shaanxi Normal University , , ,","place":["Xi\u2019an, China, 710119"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Ma","sequence":"additional","affiliation":[{"name":"Shaanxi Normal University , , ,","place":["Xi\u2019an, China, 710119"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaanxi Normal University , , ,","place":["Xi\u2019an, China, 710119"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2045-9611","authenticated-orcid":true,"given":"Xinwei","family":"Tian","sequence":"additional","affiliation":[{"name":"Shaanxi Normal University , , ,","place":["Xi\u2019an, China, 710119"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Yang","sequence":"additional","affiliation":[{"name":"Shaanxi Normal University , , ,","place":["Xi\u2019an, China, 710119"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-0525","authenticated-orcid":true,"given":"Xingbin","family":"Yang","sequence":"additional","affiliation":[{"name":"Shaanxi Normal University , , ,","place":["Xi\u2019an, China, 710119"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9571-0096","authenticated-orcid":true,"given":"Daoyuan","family":"Ren","sequence":"additional","affiliation":[{"name":"Shaanxi Normal University , , ,","place":["Xi\u2019an, China, 710119"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"11","key":"2026081208092112400_cit1","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1111\/obr.12590","article-title":"Strategies to increase\nthe efficacy of using gut microbiota for the modulation of obesity","volume":"18","author":"Li","year":"2017","journal-title":"Obes. 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