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Efficient biocatalysts for aldopentose oxidation remain limited, and few enzymes exhibit high catalytic efficiency toward both aldohexoses and aldopentoses. Here, a naturally promiscuous pyrroloquinoline quinone-dependent glucose dehydrogenase (PQQ-GDH) from Pseudomonas fragi NL20W was selected as an engineering template and tailored by semirational design to expand aldopentose oxidation while preserving native d-glucose activity. The V706P\/L723 M mutant exhibited markedly enhanced catalytic efficiency toward d-xylose and l-arabinose, reaching 8.0- and 2.4-fold those of the wild-type, respectively, while its efficiency toward d-glucose was 1.3-fold that of the wild-type. Molecular simulations suggested that the improved catalysis was associated with an optimized substrate positioning and enhanced conformational flexibility of the active-site region. This study highlights the significance of natural enzyme scaffold selection in substrate scope engineering and expands the application potential of PQQ-GDH in the sustainable valorization of lignocellulosic sugars.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08393","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:01:58Z","timestamp":1787032918000},"page":"26532-26543","source":"Crossref","is-referenced-by-count":0,"title":["Expanding Aldopentose Catalysis of a Novel PQQ-Dependent\nGlucose Dehydrogenase without Compromising Native\n                    <scp>d<\/scp>\n                    -Glucose\nActivity"],"prefix":"10.1021","volume":"74","author":[{"given":"Yuehua","family":"Chen","sequence":"first","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, People\u2019s Republic of China, 210037"]},{"name":"Nanjing Forestry University , , ,","place":["Nanjing, People\u2019s Republic of China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-209X","authenticated-orcid":true,"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu University of Science and Technology , , ,","place":["Zhenjiang, People\u2019s Republic of China, 212003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Sheng","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, People\u2019s Republic of China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Xing","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, People\u2019s Republic of China, 210037"]},{"name":"Nanjing Forestry University , , ,","place":["Nanjing, People\u2019s Republic of China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-253X","authenticated-orcid":true,"given":"Jia","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, People\u2019s Republic of China, 210037"]},{"name":"Nanjing Forestry University , , ,","place":["Nanjing, People\u2019s Republic of China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0550-7455","authenticated-orcid":true,"given":"Zhaojuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, People\u2019s Republic of China, 210037"]},{"name":"Nanjing Forestry University , , ,","place":["Nanjing, People\u2019s Republic of China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"issue":"5","key":"2026090104465808500_cit1","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1177\/193229681100500507","article-title":"Review of glucose oxidases and glucose\ndehydrogenases: a bird\u2019s eye view of glucose sensing enzymes","volume":"5","author":"Ferri","year":"2011","journal-title":"J. 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GDH-1","volume":"79","author":"Aiba","year":"2015","journal-title":"Biosci.,\nBiotechnol., Biochem."},{"key":"2026090104465808500_cit5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.enzmictec.2014.10.002","article-title":"Expression,\ncharacterization\nand mutagenesis of an FAD-dependent glucose dehydrogenase from Aspergillus\nterreus","volume":"68","author":"Yang","year":"2015","journal-title":"Enzyme Microb. 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