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Oral administration of LMW-SDF significantly reduced serum lipopolysaccharide (LPS) and diamine oxidase (DAO) levels, alleviated colonic inflammation and oxidative stress, and improved epithelial barrier integrity by upregulating Claudin-1, Occludin, and ZO-1 (P &amp;lt; 0.05). 16S rRNA sequencing demonstrated that LMW-SDF partially restored gut microbial diversity and reshaped the gut microbiota, accompanied by alterations in the abundance of Ligilactobacillus, Lactobacillus, and norank_f_Muribaculaceae. Untargeted metabolomics indicated partial recovery of CTX-induced metabolic disturbances, particularly in tryptophan, arachidonic acid, and primary bile acid metabolism. Immunofluorescence analysis further suggested that these protective effects were associated with modulation of the TLR4\/NF-\u03baB pathway. These findings support the potential application of LMW-SDF as a dietary intervention for chemotherapy-associated intestinal injury.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08406","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:01:44Z","timestamp":1789455704000},"page":"29338-29353","source":"Crossref","is-referenced-by-count":0,"title":["Low-Molecular-Weight\nSoluble Dietary Fiber Promotes\nRecovery from Cyclophosphamide-Induced Intestinal Injury: Insights\nfrom Gut Microbiota and Metabolomics"],"prefix":"10.1021","volume":"74","author":[{"given":"Wenting","family":"Yi","sequence":"first","affiliation":[{"name":"Zhejiang Ocean University , , ,","place":["Zhoushan, China, 316022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[{"name":"Hangzhou Women\u2019s Hospital , ,","place":["Hangzhou, China, 310008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liang","sequence":"additional","affiliation":[{"name":"Zhejiang Ocean University , , ,","place":["Zhoushan, China, 316022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yezhu","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Ocean University , , ,","place":["Zhoushan, China, 316022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Pan","sequence":"additional","affiliation":[{"name":"Zhejiang Ocean University , , ,","place":["Zhoushan, China, 316022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Ocean University , , ,","place":["Zhoushan, China, 316022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Han","sequence":"additional","affiliation":[{"name":"Zhejiang Ocean University , , ,","place":["Zhoushan, China, 316000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-2956","authenticated-orcid":true,"given":"Yunping","family":"Tang","sequence":"additional","affiliation":[{"name":"Zhejiang Ocean University , , ,","place":["Zhoushan, China, 316022"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"8","key":"2026092310090500100_cit1","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.3390\/foods14081416","article-title":"Lactobacillus murinus ZNL-13 modulates intestinal barrier damage and gut\nmicrobiota in cyclophosphamide-induced immunosuppressed mice","volume":"14","author":"Dong","year":"2025","journal-title":"Foods"},{"key":"2026092310090500100_cit2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1128\/mBio.02903-18","article-title":"A more robust gut microbiota in calorie-restricted mice is associated\nwith attenuated intestinal injury caused by the chemotherapy drug\ncyclophosphamide","volume":"10","author":"Liu","year":"2019","journal-title":"MBio."},{"issue":"8","key":"2026092310090500100_cit3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms regulating intestinal\nbarrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. 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