{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:07:46Z","timestamp":1788991666304,"version":"build-2803163510"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308885\/2025-2"],"award-info":[{"award-number":["308885\/2025-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["420894\/2025-0"],"award-info":[{"award-number":["420894\/2025-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["12\/2024 (503\/2025)"],"award-info":[{"award-number":["12\/2024 (503\/2025)"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["21\/2022 - (1069\/2022 P: 2022-98VRN)"],"award-info":[{"award-number":["21\/2022 - (1069\/2022 P: 2022-98VRN)"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cacao fruit maturation directly influences the chemical composition of tissues that are central to chocolate production and byproduct valorization, yet its lipid remodeling remains unexplored. Here, an untargeted UHPLC\u2013Orbitrap\u2013MS lipidomics workflow was used to map lipid profile changes in cacao seeds and cacao pod husk (CPH) across three maturation stages (green, intermediate, and ripe). In seeds, 290 lipid species were annotated, with most lipid classes showing lower relative abundance at the mature stage. Major cocoa butter triacylglycerols exhibited selective accumulation, revealing that maturation involves targeted lipid reorganization rather than a generalized increase in storage lipids. In CPH, 224 lipid species were annotated, with limited variation at the class level but pronounced species-specific changes; steryl esters, diacylglycerols, hydroxy fatty acids, and acylated sterol glycosides increased during ripening. These trends indicate distinct metabolic roles for storage and protective tissues during cacao development.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08470","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:20:48Z","timestamp":1788351648000},"page":"28039-28052","source":"Crossref","is-referenced-by-count":0,"title":["From Green to Ripe:\nUntargeted UHPLC\u2013Orbitrap\u2013MS\nLipidomic Profiling of Cacao Seed and Pod Husk during Maturation"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7879-651X","authenticated-orcid":true,"given":"Joa\u0303o V. M. de","family":"Almeida","sequence":"first","affiliation":[{"name":"Federal University of Espi\u0301rito Santo\/UFES , , Campus Goiabeiras, Avenida Fernando Ferrari, 514 , , ,","place":["Vitoria, Espi\u0301rito Santo, Brazil, 29075-910"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-6403","authenticated-orcid":true,"given":"Daniel S.","family":"Trancoso","sequence":"additional","affiliation":[{"name":"Federal University of Espi\u0301rito Santo\/UFES , , Campus Maruipe, Avenida Marechal Campos, 1468 , , ,","place":["Vitoria, Espi\u0301rito Santo, Brazil, 29043-213"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-9641","authenticated-orcid":true,"given":"Eclair","family":"V. Filho","sequence":"additional","affiliation":[{"name":"Federal University of Espi\u0301rito Santo\/UFES , , Campus Maruipe, Avenida Marechal Campos, 1468 , , ,","place":["Vitoria, Espi\u0301rito Santo, Brazil, 29043-213"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4598-3890","authenticated-orcid":true,"given":"Alan R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Federal University of Espi\u0301rito Santo\/UFES , , Campus Goiabeiras, Avenida Fernando Ferrari, 514 , , ,","place":["Vitoria, Espi\u0301rito Santo, Brazil, 29075-910"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C. F.","family":"Braz","sequence":"additional","affiliation":[{"name":"Federal Institute of Espi\u0301rito Santo\/IFES , Campus Vila Velha, Av. Ministro Salgado Filho , , ,","place":["Vila Velha, Espi\u0301rito Santo, Brazil, 29106-010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-7642","authenticated-orcid":true,"given":"Natha\u0301lia dos S.","family":"Conceic\u0327a\u0303o","sequence":"additional","affiliation":[{"name":"Federal University of Espi\u0301rito Santo\/UFES , , Campus Goiabeiras, Avenida Fernando Ferrari, 514 , , ,","place":["Vitoria, Espi\u0301rito Santo, Brazil, 29075-910"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M. M.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Federal Institute of Espi\u0301rito Santo\/IFES , Campus Vila Velha, Av. Ministro Salgado Filho , , ,","place":["Vila Velha, Espi\u0301rito Santo, Brazil, 29106-010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio V.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Federal Institute of Espi\u0301rito Santo\/IFES , Campus Linhares, Av. Filogo\u0302nio Peixoto , , ,","place":["Linhares, Espi\u0301rito Santo, Brazil, 29901-291"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2754-2013","authenticated-orcid":true,"given":"Nayara A.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Federal Institute of Espi\u0301rito Santo\/IFES , Campus Vito\u0301ria, Av. Vito\u0301ria , , ,","place":["Vito\u0301ria, Espi\u0301rito Santo, Brazil, 29040-780"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo M.","family":"Kuster","sequence":"additional","affiliation":[{"name":"Federal University of Espi\u0301rito Santo\/UFES , , Campus Goiabeiras, Avenida Fernando Ferrari, 514 , , ,","place":["Vitoria, Espi\u0301rito Santo, Brazil, 29075-910"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanderson","family":"Roma\u0303o","sequence":"additional","affiliation":[{"name":"Federal University of Espi\u0301rito Santo\/UFES , , Campus Goiabeiras, Avenida Fernando Ferrari, 514 , , ,","place":["Vitoria, Espi\u0301rito Santo, Brazil, 29075-910"]},{"name":"Federal University of Espi\u0301rito Santo\/UFES , , Campus Maruipe, Avenida Marechal Campos, 1468 , , ,","place":["Vitoria, Espi\u0301rito Santo, Brazil, 29043-213"]},{"name":"Federal Institute of Espi\u0301rito Santo\/IFES , Campus Vila Velha, Av. Ministro Salgado Filho , , ,","place":["Vila Velha, Espi\u0301rito Santo, Brazil, 29106-010"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"2026090917081663100_cit1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/bs.agron.2016.10.017","article-title":"Mineral Nutrition of Cocoa","volume":"141","author":"van Vliet","year":"2017","journal-title":"Adv. Agronomy"},{"issue":"2","key":"2026090917081663100_cit2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s12298-018-0632-2","article-title":"Morphological and Genetic\nDiversity\nof Cacao (Theobroma Cacao L.) in Uganda","volume":"25","author":"Gopaulchan","year":"2019","journal-title":"Physiol.\nMol. Biol. Plants"},{"issue":"1","key":"2026090917081663100_cit3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1744-7348.2009.00356.x","article-title":"Phenological Growth Stages of Cacao\nPlants (Theobroma Sp.): Codification and Description According to\nthe BBCH Scale","volume":"156","author":"Niemenak","year":"2010","journal-title":"Ann. Appl. Biol."},{"issue":"12","key":"2026090917081663100_cit4","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1038\/s41559-018-0697-x","article-title":"The Use and\nDomestication of Theobroma\nCacao during the Mid-Holocene in the Upper Amazon","volume":"2","author":"Zarrillo","year":"2018","journal-title":"Nat. Ecol. Evol."},{"issue":"2","key":"2026090917081663100_cit5","doi-asserted-by":"publisher","first-page":"022095","DOI":"10.1088\/1755-1315\/839\/2\/022095","article-title":"Contemporary\nGlobal Production and Consumption of Cocoa: An Assessment","volume":"839","author":"Gavrilova","year":"2021","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"2026090917081663100_cit6","doi-asserted-by":"publisher","first-page":"145718","DOI":"10.1016\/j.foodchem.2025.145718","article-title":"Functional and Technological Potential\nof By-Products from the Cocoa (Theobroma Cacao L.) Production Chain","volume":"493","author":"Nascimento","year":"2025","journal-title":"Food Chem."},{"key":"2026090917081663100_cit7","doi-asserted-by":"publisher","first-page":"104115","DOI":"10.1016\/j.jfca.2021.104115","article-title":"Cocoa and Cocoa Bean\nShells Role in Human Health: An Updated Review","volume":"103","author":"Cinar","year":"2021","journal-title":"J. Food Compos. Anal."},{"issue":"1","key":"2026090917081663100_cit8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/pbi.12848","article-title":"Cacao Biotechnology: Current Status and Future Prospects","volume":"16","author":"Wickramasuriya","year":"2018","journal-title":"Plant Biotechnol. J."},{"key":"2026090917081663100_cit9","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1089\/ars.2010.3697","article-title":"Cocoa and\nChocolate in Human Health\nand Disease","volume":"15","author":"Katz","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"2026090917081663100_cit10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.tifs.2017.03.007","article-title":"Cocoa\nShell and Its Compounds: Applications in the Food Industry","volume":"63","author":"Okiyama","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"2026090917081663100_cit11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.foodres.2016.01.012","article-title":"Factors Influencing\nQuality Variation in Cocoa (Theobroma\nCacao) Bean Flavour Profile \u2500 A Review","volume":"82","author":"Kongor","year":"2016","journal-title":"Food Res. Int."},{"key":"2026090917081663100_cit12","doi-asserted-by":"publisher","first-page":"133845","DOI":"10.1016\/j.foodchem.2022.133845","article-title":"Lipidomic\nProfiling of Bioactive\nLipids during Spontaneous Fermentations of Fine-Flavor Cocoa","volume":"397","author":"Herrera-Rocha","year":"2022","journal-title":"Food Chem."},{"key":"2026090917081663100_cit13","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.foodres.2018.02.070","article-title":"Assessment of Cocoa (Theobroma Cacao\nL.) Butter Content and Composition throughout Fermentations","volume":"107","author":"Servent","year":"2018","journal-title":"Food Res. Int."},{"issue":"1","key":"2026090917081663100_cit14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-arplant-081519-035910","article-title":"Functions of Anionic Lipids in Plants","volume":"71","author":"Noack","year":"2020","journal-title":"Annu. Rev. Plant Biol."},{"issue":"7","key":"2026090917081663100_cit15","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3390\/plants9070871","article-title":"Lipid Metabolism\nin Plants","volume":"9","author":"Kim","year":"2020","journal-title":"Plants"},{"issue":"6","key":"2026090917081663100_cit16","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1111\/1541-4337.13225","article-title":"An Overview\nof Food Lipids toward Food Lipidomics","volume":"22","author":"Tietel","year":"2023","journal-title":"Compr.\nRev. Food Sci. Food Saf."},{"issue":"6","key":"2026090917081663100_cit17","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3390\/metabo13060727","article-title":"Lipidomic\nProfiles\nof Lipid Biosynthesis in Oil Palm during Fruit Development","volume":"13","author":"Martin","year":"2023","journal-title":"Metabolites"},{"issue":"1","key":"2026090917081663100_cit18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s44307-024-00017-9","article-title":"Exploring\nthe Plant Lipidome: Techniques, Challenges, and Prospects","volume":"2","author":"Liu","year":"2024","journal-title":"Advanced Biotechnol."},{"issue":"5","key":"2026090917081663100_cit19","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1007\/s13361-017-1608-0","article-title":"Expanding\nLipidome\nCoverage Using LC-MS\/MS Data-Dependent Acquisition with Automated\nExclusion List Generation","volume":"28","author":"Koelmel","year":"2017","journal-title":"J. Am. Soc. Mass\nSpectrom."},{"key":"2026090917081663100_cit20","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/B978-0-08-100596-5.22797-2","article-title":"Review on Cocoa\nLipidomics \u2013 State of Knowledge and Future Needs","volume-title":"Comprehensive Foodomics","author":"Sirbu","year":"2021"},{"key":"2026090917081663100_cit21","doi-asserted-by":"publisher","first-page":"112555","DOI":"10.1016\/j.foodres.2023.112555","article-title":"Omics Approaches\nto Understand Cocoa Processing and\nChocolate Flavor Development: A Review","volume":"165","author":"Herrera-Rocha","year":"2023","journal-title":"Food\nRes. Int."},{"issue":"2","key":"2026090917081663100_cit22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.foodres.2004.09.008","article-title":"Analysis\nof Triacylglycerol Isomers in Malaysian Cocoa Butter Using HPLC\u2013Mass\nSpectrometry","volume":"38","author":"Segall","year":"2005","journal-title":"Food Res. Int."},{"key":"2026090917081663100_cit23","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.foodres.2018.05.025","article-title":"Variation\nof Triacylglycerol Profiles in Unfermented and Dried Fermented Cocoa\nBeans of Different Origins","volume":"111","author":"Sirbu","year":"2018","journal-title":"Food Res. Int."},{"key":"2026090917081663100_cit24","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.foodchem.2014.05.141","article-title":"Nutritional\nComposition and Fatty Acids Profile in Cocoa Beans and Chocolates\nwith Different Geographical Origin and Processing Conditions","volume":"166","author":"Torres-Moreno","year":"2015","journal-title":"Food Chem."},{"issue":"1","key":"2026090917081663100_cit25","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s42994-024-00194-0","article-title":"Plant Metabolomics:\nApplications and Challenges in the Era of Multi-Omics Big Data","volume":"6","author":"Hao","year":"2025","journal-title":"aBIOTECH"},{"issue":"1","key":"2026090917081663100_cit26","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1186\/s12870-025-07590-8","article-title":"Metabolomic and Transcriptomic Analyses\nProvide Insights\ninto Metabolic Networks during Fragaria Nilgerrensis Fruit Development\nand Ripening","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Plant Biol."},{"key":"2026090917081663100_cit27","unstructured":"MassBank of North America (MoNA).\n          \n          MoNA Spectral Database\nDownloads. https:\/\/mona.fiehnlab.ucdavis.edu\/downloads\/) (January 15, 2026)."},{"key":"2026090917081663100_cit28","unstructured":"Global Natural Products Social Molecular Networking GNPS2.\n          \n          https:\/\/gnps2.org\/homepage\/, 2026."},{"issue":"6","key":"2026090917081663100_cit29","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: Data-Independent MS\/MS Deconvolution\nfor Comprehensive Metabolome Analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat.\nMethods"},{"issue":"W1","key":"2026090917081663100_cit30","doi-asserted-by":"publisher","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: Towards a Unified Platform for Metabolomics Data\nProcessing, Analysis and Interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic\nAcids Res."},{"issue":"3","key":"2026090917081663100_cit31","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed Minimum Reporting Standards for Chemical Analysis","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"2026090917081663100_cit32","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.tifs.2018.09.022","article-title":"Cocoa (Theobroma\nCacao L.) Pod Husk:\nRenewable Source of Bioactive Compounds","volume":"81","author":"Campos-Vega","year":"2018","journal-title":"Trends\nFood Sci. Technol."},{"issue":"5","key":"2026090917081663100_cit33","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.3390\/molecules27051625","article-title":"Cocoa By-Products: Characterization\nof Bioactive Compounds\nand Beneficial Health Effects","volume":"27","author":"Soares","year":"2022","journal-title":"Molecules"},{"key":"2026090917081663100_cit34","doi-asserted-by":"publisher","first-page":"113412","DOI":"10.1016\/j.phytochem.2022.113412","article-title":"Analysis of Fruit Ripening\nin Theobroma Cacao Pod Husk\nBased on Untargeted Metabolomics","volume":"203","author":"Gallego","year":"2022","journal-title":"Phytochemistry"},{"issue":"1","key":"2026090917081663100_cit35","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.15376\/biores.16.1.Ouattara","article-title":"Cocoa Pod\nHusks as Potential Sources of Renewable High-Value-Added Products:\nA Review of Current Valorizations and Future Prospects","volume":"16","author":"Ouattara","year":"2020","journal-title":"BioResources"},{"issue":"8","key":"2026090917081663100_cit36","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.32604\/jrm.2025.02024-0078","article-title":"Sustainable\nBiocomposites from Renewable Resources in West Africa: A Review","volume":"13","author":"Mansour","year":"2025","journal-title":"J. Renew. Mater."},{"issue":"91","key":"2026090917081663100_cit37","doi-asserted-by":"publisher","first-page":"95","DOI":"10.17533\/udea.redin.n91a09","article-title":"Supercritical\nExtraction of Bioactive Compounds from Cocoa Husk: Study of the Main\nParameters","author":"Herna\u0301ndez","year":"2019","journal-title":"Revista Facultad de Ingenieria"},{"key":"2026090917081663100_cit38","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0377-8401(94)90127-9","article-title":"Utilization of Cocoa-Pod\nPericarp Fractions in Broiler\nChick Diets","volume":"47","author":"Sobamiwa","year":"1994","journal-title":"Anim. Feed Sci. Technol."},{"issue":"2","key":"2026090917081663100_cit39","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1073\/pnas.1214159110","article-title":"AtABCA9 Transporter\nSupplies Fatty Acids for Lipid Synthesis to the\nEndoplasmic Reticulum","volume":"110","author":"Kim","year":"2013","journal-title":"Proc. Natl. Acad. Sci.\nU. S. A."},{"key":"2026090917081663100_cit40","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fpls.2021.640996","article-title":"Functional Role of Long-Chain Acyl-CoA\nSynthetases in Plant Development and Stress Responses","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Plant Sci."},{"key":"2026090917081663100_cit41","doi-asserted-by":"publisher","first-page":"461939","DOI":"10.1016\/j.chroma.2021.461939","article-title":"Dual Derivatization\nStrategy for the Comprehensive Quantification and Double Bond Location\nCharacterization of Fatty Acids by Ultra-High Performance Liquid Chromatography-Tandem\nMass Spectrometry","volume":"1639","author":"Hu","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"2026090917081663100_cit42","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.foodchem.2018.01.194","article-title":"Characterization of\nTriacylglycerols in Unfermented Cocoa Beans by HPLC-ESI Mass Spectrometry","volume":"254","author":"Sirbu","year":"2018","journal-title":"Food Chem."},{"key":"2026090917081663100_cit43","doi-asserted-by":"publisher","first-page":"167358","DOI":"10.1016\/j.scitotenv.2023.167358","article-title":"Hydroxy Fatty\nAcids in the Surface\nEarth System","volume":"906","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"1","key":"2026090917081663100_cit44","doi-asserted-by":"publisher","first-page":"11421","DOI":"10.1038\/s41467-025-66337-z","article-title":"Chromosome-Level Assembly and Analysis\nof Three Hydroxy Fatty Acid-Producing Physaria Species","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"2026090917081663100_cit45","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fpls.2022.984100","article-title":"Effects of\nImpaired Steryl Ester\nBiosynthesis on Tomato Growth and Developmental Processes","volume":"13","author":"Burciaga-Monge","year":"2022","journal-title":"Front. Plant Sci."},{"issue":"1","key":"2026090917081663100_cit46","doi-asserted-by":"publisher","DOI":"10.1111\/ppl.70022","article-title":"Differential Impact\nof Impaired Steryl Ester Biosynthesis on the Metabolome of Tomato\nFruits and Seeds","volume":"177","author":"Lo\u0301pez-Tubau","year":"2025","journal-title":"Physiol. Plant"},{"issue":"2","key":"2026090917081663100_cit47","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11745-011-3602-9","article-title":"Steryl Glucoside\nand Acyl Steryl\nGlucoside Analysis of Arabidopsis Seeds by Electrospray Ionization\nTandem Mass Spectrometry","volume":"47","author":"Schrick","year":"2012","journal-title":"Lipids"},{"key":"2026090917081663100_cit48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.plipres.2017.06.002","article-title":"Emerging Roles for\nConjugated Sterols in Plants","volume":"67","author":"Ferrer","year":"2017","journal-title":"Prog. Lipid Res."},{"issue":"3","key":"2026090917081663100_cit49","doi-asserted-by":"publisher","first-page":"528","DOI":"10.21273\/JASHS.116.3.528","article-title":"Growth\nConditions and Ripening Influence Plastid and Microsomal Membrane\nLipid Composition in Bell Pepper Fruit","volume":"116","author":"Whitaker","year":"1991","journal-title":"J. AMER.\nSoc. HORT. SCI."},{"issue":"11","key":"2026090917081663100_cit50","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1016\/0031-9422(88)80740-4","article-title":"CHANGES\nIN THE STERYL LIPID CONTENT AND COMPOSITION OF TOMATO FRUIT DURING\nRIPENING","volume":"27","author":"Whitaker","year":"1988","journal-title":"Phytochemrstry"},{"issue":"6","key":"2026090917081663100_cit51","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/0031-9422(95)00189-E","article-title":"Lipid Evolution during Development\nand Ripening of Peach Fruits","volume":"39","author":"Izzo","year":"1995","journal-title":"Phytochemistry"},{"key":"2026090917081663100_cit52","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fpls.2012.00147","article-title":"The Significance of Different Diacylgycerol Synthesis\nPathways on Plant Oil Composition and Bioengineering","volume":"3","author":"Bates","year":"2012","journal-title":"Front. Plant Sci."},{"issue":"1","key":"2026090917081663100_cit53","doi-asserted-by":"publisher","first-page":"17263","DOI":"10.1038\/s41598-019-53959-9","article-title":"Transcriptional\nProfiling Reveals Differentially Expressed Genes\nInvolved in Lipid Biosynthesis during Cacao Seed Development","volume":"9","author":"Li","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"2026090917081663100_cit54","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1248\/bpb.b15-00575","article-title":"Plant Lysophosphatidic Acids: A Rich\nSource for Bioactive\nLysophosphatidic Acids and Their Pharmacological Applications","volume":"39","author":"Lee","year":"2016","journal-title":"Biol. Pharm. Bull."},{"issue":"8","key":"2026090917081663100_cit55","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/BF02534902","article-title":"Tissue Culture of\nCocoa Bean (Theobroma Cacao L.):\nChanges in Lipids during Maturation of Beans and Growth of Cells and\nCalli in Culture","volume":"16","author":"Tsai","year":"1981","journal-title":"Lipids"},{"issue":"1","key":"2026090917081663100_cit56","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1146\/annurev-arplant-043015-111641","article-title":"Triacylglycerol Metabolism,\nFunction, and Accumulation\nin Plant Vegetative Tissues","volume":"67","author":"Xu","year":"2016","journal-title":"Annu. Rev. Plant\nBiol."},{"issue":"3","key":"2026090917081663100_cit57","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/tpj.13201","article-title":"System Level\nAnalysis of Cacao Seed Ripening Reveals a Sequential Interplay of\nPrimary and Secondary Metabolism Leading to Polyphenol Accumulation\nand Preparation of Stress Resistance","volume":"87","author":"Wang","year":"2016","journal-title":"Plant\nJ."},{"issue":"2","key":"2026090917081663100_cit58","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/tpj.14324","article-title":"The Onset of Embryo Maturation in\nArabidopsis Is Determined by Its Developmental Stage and Does Not\nDepend on Endosperm Cellularization","volume":"99","author":"O\u2019Neill","year":"2019","journal-title":"Plant J."},{"issue":"4","key":"2026090917081663100_cit59","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0168-9452(03)00011-6","article-title":"Oil Bodies\nin Theobroma Cacao Seeds: Cloning and Characterization\nof CDNA Encoding the 15.8 and 16.9 KDa Oleosins","volume":"164","author":"Guilloteau","year":"2003","journal-title":"Plant Sci."},{"issue":"3","key":"2026090917081663100_cit60","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1399-3054.1989.tb05662.x","article-title":"Changes in\nPolar Lipids during Ripening\nand Senescence of Cherry Tomato (Lycopersicon Esculentum): Relation\nto Climacteric and Ethylene Increases","volume":"77","author":"Gu\u0308c\u0327lu\u0308","year":"1989","journal-title":"Physiol.\nPlant"},{"key":"2026090917081663100_cit61","doi-asserted-by":"publisher","first-page":"101377","DOI":"10.1016\/j.plipres.2026.101377","article-title":"Phospholipids in Plant\nSystems: Metabolism, Regulation and Functional Insights","volume":"101","author":"Xiao","year":"2026","journal-title":"Prog. Lipid Res."},{"key":"2026090917081663100_cit62","doi-asserted-by":"publisher","first-page":"147366","DOI":"10.1016\/j.foodchem.2025.147366","article-title":"Integrated Metabolomics and Lipidomics for In-Depth\nUnderstanding of Dynamic Metabolic Changes in Passion Fruit with Different\nRipeness","volume":"499","author":"Zhu","year":"2026","journal-title":"Food Chem."},{"key":"2026090917081663100_cit63","doi-asserted-by":"publisher","first-page":"154454","DOI":"10.1016\/j.jplph.2025.154454","article-title":"Phospholipid\nSignaling in Plant Growth\nand Development: Insights, Biotechnological Implications and Future\nDirections","volume":"307","author":"Oubohssaine","year":"2025","journal-title":"J. Plant Physiol."},{"key":"2026090917081663100_cit64","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.81355","article-title":"Plant Lipid Metabolism","author":"Fatiha","journal-title":"Adv. Lipid Metabolism."},{"issue":"3","key":"2026090917081663100_cit65","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S1360-1385(01)02216-6","article-title":"Galactolipids Rule in Seed Plants","volume":"7","author":"Do\u0308rmann","year":"2002","journal-title":"Trends Plant Sci."},{"issue":"4","key":"2026090917081663100_cit66","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s12013-020-00947-w","article-title":"Lipids Composition\nin Plant Membranes","volume":"78","author":"Reszczyn\u0301ska","year":"2020","journal-title":"Cell Biochem. Biophys."},{"issue":"13","key":"2026090917081663100_cit67","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.3390\/plants12132393","article-title":"Fruit Photosynthesis:\nMore to Know about Where, How and Why","volume":"12","author":"Garrido","year":"2023","journal-title":"Plants"},{"issue":"2","key":"2026090917081663100_cit68","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0168-9452(93)90089-I","article-title":"Isolation of Intact\nProplastids from Suspension Cultured\nCells of Theobroma Cacao L.: De Novo Long Chain Fatty Acid Biosynthesis","volume":"88","author":"Leathers","year":"1993","journal-title":"Plant Sci."},{"key":"2026090917081663100_cit69","doi-asserted-by":"publisher","first-page":"127808","DOI":"10.1016\/j.foodchem.2020.127808","article-title":"Formation and properties\nof dark\nchocolate prepared using fat mixtures of cocoa butter and symmetric\/asymmetric\nstearic-oleic mixed-acid triacylglycerols: Impact of molecular compound\ncrystals","volume":"339","author":"Watanabe","year":"2021","journal-title":"Food Chem."},{"key":"2026090917081663100_cit70","doi-asserted-by":"publisher","first-page":"5018","DOI":"10.1038\/s41467-021-25206-1","article-title":"Tempering\nof cocoa butter and chocolate using minor lipidic components","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"2026090917081663100_cit71","doi-asserted-by":"publisher","first-page":"107791","DOI":"10.1016\/j.biotechadv.2021.107791","article-title":"Microbial\nlipid biosynthesis from lignocellulosic biomass\npyrolysis products","volume":"54","author":"Palazzolo","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"2026090917081663100_cit72","doi-asserted-by":"publisher","first-page":"123067","DOI":"10.1016\/j.apcatb.2023.123067","article-title":"Catalytic\npyrolysis of fatty acids and oils into liquid biofuels and chemicals\nover supported Ni catalysts on biomass-derived carbon","volume":"338","author":"Chen","year":"2023","journal-title":"Appl. Catal., B"},{"issue":"4","key":"2026090917081663100_cit73","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/tpj.12427","article-title":"N -Acylethanolamines: Lipid Metabolites with Functions\nin Plant Growth and Development","volume":"79","author":"Blancaflor","year":"2014","journal-title":"Plant J."},{"key":"2026090917081663100_cit74","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/bs.abr.2021.07.002","article-title":"The Biosynthesis and Roles of N-Acylethanolamines in\nPlants","volume":"101","author":"Arias-Gaguancela","year":"2022","journal-title":"Adv. Botanical. Res."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c08470","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/35\/28039\/67739509\/acs.jafc.6c08470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/35\/28039\/67739509\/acs.jafc.6c08470.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:20:02Z","timestamp":1788988802000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/35\/28039\/5361411\/From-Green-to-Ripe-Untargeted-UHPLC-Orbitrap-MS"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":74,"journal-issue":{"issue":"35","published-online":{"date-parts":[[2026,8,29]]},"published-print":{"date-parts":[[2026,9,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c08470","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]}}}