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Using a static in vitro model, we compared a seaweed-yak meat matrix under four simulated older-adult gastrointestinal conditions: normal gastric and intestinal function, isolated intestinal dysfunction, isolated gastric dysfunction, and combined dysfunction. Intestinal digestion decreased particle size from 2325.03 nm to 731.74\u20131088.07 nm and significantly increased apparent protein digestibility from 9.72\u201329.05% to 73.27\u201383.73% (P &amp;lt; 0.05). Combined dysfunction significantly reduced terminal digestibility to 73.27% compared with 83.73% under normal conditions (P &amp;lt; 0.05) and retained larger, heterogeneous aggregates. Peptides of 801\u20131400 Da predominated (45.5\u201345.8%), while 18,499 of 19,681 peptides (94%) were shared among groups. Peptides uniquely assigned to yak proteins accounted for 97.039\u201397.466% of normalized precursor-ion abundance, whereas seaweed-only peptides accounted for 0.1078\u20130.1241%. Peptide clustering indicated abundance remodeling within a conserved, yak-dominated pool, with terminal profiles more strongly associated with gastric than isolated intestinal dysfunction.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08704","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:02:24Z","timestamp":1789653744000},"page":"30144-30158","source":"Crossref","is-referenced-by-count":0,"title":["Digestive Fate of a Seaweed-Yak Meat Protein\u2013Polysaccharide\nMatrix under Simulated Elderly Gastrointestinal Dysfunction: Nutrient\nRelease, Antioxidant Response, and Peptidomic Remodeling"],"prefix":"10.1021","volume":"74","author":[{"given":"Yujiao","family":"Wang","sequence":"first","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saijie","family":"Ma","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Li","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Fan","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Han","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1805-4325","authenticated-orcid":true,"given":"Hang","family":"Qi","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026093009082208300_cit1","doi-asserted-by":"publisher","first-page":"1683158","DOI":"10.3389\/fnagi.2025.1683158","article-title":"Trends and cross-country\ninequalities in the global burden of Alzheimer\u2019s disease and\nother dementias among adults aged 65+ years, 1990\u20132021: a population\nbased study with projections into 2050","volume":"17","author":"Liu","year":"2026","journal-title":"Front.\nAging Neurosci."},{"issue":"2","key":"2026093009082208300_cit2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3390\/md20020141","article-title":"An Overview\nof Potential Seaweed-Derived\nBioactive Compounds for Pharmaceutical Applications","volume":"20","author":"Lomartire","year":"2022","journal-title":"Mar. 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