{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:49:41Z","timestamp":1791391781924,"version":"4.3.3"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/P33636"],"award-info":[{"award-number":["10.55776\/P33636"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dietary antioxidants offer protection against oxidative bursts caused by high-intensity physical exercise. However, their acute effects on specific lipid oxidation products, especially oxidized phosphatidylcholine (oxPC) and oxysterols, remain underexplored in human plasma. Nineteen female participants underwent a crossover study involving pre-exercise intake of either polyphenol-enriched flaxseed oil (FO) or water (control), followed by standardized high-intensity interval training (HIIT). Plasma collected at four time points (pre- to post-HIIT) was analyzed via targeted LC-MS\/MS for oxPCs and oxysterols and untargeted lipidomics using LC-QTOF-MS. FO significantly suppressed the postexercise rise in oxPCs (e.g., SONPC, KOOA-PC, KDdiA-PC) and nonenzymatically formed oxysterols (7-ketocholesterol, 7\u03b2-hydroxycholesterol). Orthogonal PLS-DA showed obvious postexercise group separation between FO-consuming subjects versus control. Untargeted lipidomics revealed broader remodeling of the phospholipidome in the FO group. This study provides novel evidence that polyphenol-rich FO acutely mitigates lipid peroxidation, supporting its potential as a nutritional strategy for oxidative stress management.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08737","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:04:48Z","timestamp":1790089488000},"page":"31240-31252","source":"Crossref","is-referenced-by-count":0,"title":["Oxidomics of Human\nPlasma Reveals Lower Oxidized Lipids\nAfter Acute Intake of Polyphenol-Enriched Flaxseed Oil: A Randomized\nCrossover Exercise Trial"],"prefix":"10.1021","volume":"74","author":[{"given":"Fawzan Sigma","family":"Aurum","sequence":"first","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]},{"name":"National Research and Innovation Agency , , ,","place":["Yogyakarta, Indonesia, 55861"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Brem","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0078-1612","authenticated-orcid":true,"given":"Matthias","family":"Strauss","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]},{"name":"University of Vienna , , Wa\u0308hringer Str. 42 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gassner","sequence":"additional","affiliation":[{"name":"University of Vienna , , ,","place":["Vienna, Austria, 1090"]},{"name":"University of Vienna , , Josef-Holaubek-Platz , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ko\u0308nig","sequence":"additional","affiliation":[{"name":"University of Vienna , , ,","place":["Vienna, Austria, 1090"]},{"name":"University of Vienna , , Auf der Schmelz 6 , ,","place":["Vienna, Austria, 1150"]},{"name":"University of Vienna , , Josef-Holaubek-Platz , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5793-8572","authenticated-orcid":true,"given":"Marc","family":"Pignitter","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"5","key":"2026100711062877300_cit1","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3390\/nu11051171","article-title":"Dietary Flaxseed as a Strategy for Improving Human\nHealth","volume":"11","author":"Parikh","year":"2019","journal-title":"Nutrients"},{"issue":"9","key":"2026100711062877300_cit2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0828-282X(10)70455-4","article-title":"The Cardiovascular\nEffects of Flaxseed and Its Omega-3 Fatty Acid, Alpha-Linolenic Acid","volume":"26","author":"Rodriguez-Leyva","year":"2010","journal-title":"Can. 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