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At 20 mg\/L, most target compounds exhibited \u226580% inhibition against Valsa mali, Botrytis cinerea, Curvularia lunata, and Phytophthora capsici. Notably, compound G33 showed potent activity against B. cinerea (EC50 = 0.17 mg\/L) and P. capsici (EC50 = 0.42 mg\/L), outperforming commercial fungicides thifluzamide and boscalid. At 100 mg\/L, G33 effectively suppressed B. cinerea infection on strawberries. Mechanistic studies revealed that G33 disrupted hyphal morphology and ultrastructure, compromised cell membrane integrity, dissipated mitochondrial membrane potential, and inhibited mycelial growth. Enzyme activity assays, molecular docking, and molecular dynamics (MD) simulations further confirmed that G33 directly targets succinate dehydrogenase. Combined with favorable theoretical calculation results and low toxicity, G33 emerges as a promising lead compound for developing highly efficient and environmentally benign agricultural fungicides.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08778","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:17:14Z","timestamp":1785849434000},"page":"24688-24701","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Antifungal Activity of Novel\nThiazole-2-carboxamide Derivatives Bearing Flexible Diaryl Linkers\nas Succinate Dehydrogenase Inhibitors"],"prefix":"10.1021","volume":"74","author":[{"given":"Chao","family":"Zhang","sequence":"first","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ge","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjian","family":"Huang","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxiang","family":"Mao","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-9042","authenticated-orcid":true,"given":"Xiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0015","authenticated-orcid":true,"given":"Xianhai","family":"Lv","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-6612","authenticated-orcid":true,"given":"Xihao","family":"Chang","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026081208093718000_cit1","doi-asserted-by":"publisher","first-page":"670135","DOI":"10.3389\/fmicb.2021.670135","article-title":"Research\nprogress on phytopathogenic fungi and their role as biocontrol agents","volume":"12","author":"Peng","year":"2021","journal-title":"Front. 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