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Their protective effects were evaluated in early-weaned piglets challenged with enterotoxigenic Escherichia coli K88 (ETEC K88). L. reuteri CICC 6118 synthesized SeNPs with diameters of approximately 70\u2013190 nm and achieved a Na2SeO3 conversion efficiency of 97%. The purified SeNPs exhibited antioxidant activity and reduced bacterial culture turbidity in preliminary assays. In ETEC K88-challenged piglets, dietary SeNPs supplied at the same supplemental selenium concentration as Na2SeO3 improved growth performance, reduced diarrhea incidence, enhanced colonic barrier integrity, and attenuated inflammatory and oxidative responses. SeNPs also increased antioxidant enzyme activities, selenoprotein-related gene expression, and colonic short-chain fatty acid concentrations. These findings support L. reuteri CICC 6118-derived SeNPs as a functional selenium source for alleviating ETEC K88-induced intestinal injury under the dietary conditions tested.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c08995","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:01:40Z","timestamp":1790157700000},"page":"30610-30623","source":"Crossref","is-referenced-by-count":0,"title":["Preparation and\nCharacteristics of Selenium Nanoparticles\nSynthesized by\n                    <i>Limosilactobacillus reuteri<\/i>\n                    CICC 6118 and Their Protective Effects on Intestinal Injury in Early-Weaned\nPiglets"],"prefix":"10.1021","volume":"74","author":[{"given":"Xiaonan","family":"Zeng","sequence":"first","affiliation":[{"name":"Northwestern Polytechnical University , , 1 Dongxiang Road , , ,","place":["Xi\u2019an, Shaanxi, China, 710129"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjing","family":"Deng","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , 1 Dongxiang Road , , ,","place":["Xi\u2019an, Shaanxi, China, 710129"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Chang","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , 1 Dongxiang Road , , ,","place":["Xi\u2019an, Shaanxi, China, 710129"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , 1 Dongxiang Road , , ,","place":["Xi\u2019an, Shaanxi, China, 710129"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , 1 Dongxiang Road , , ,","place":["Xi\u2019an, Shaanxi, China, 710129"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Gao","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , 1 Dongxiang Road , , ,","place":["Xi\u2019an, Shaanxi, China, 710129"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Li","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , 1 Dongxiang Road , , ,","place":["Xi\u2019an, Shaanxi, China, 710129"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-5046","authenticated-orcid":true,"given":"Chunlan","family":"Xu","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , 1 Dongxiang Road , , ,","place":["Xi\u2019an, Shaanxi, China, 710129"]},{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University , , , ,","place":["Xi\u2019an, Shaanxi, China, 710061"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"4","key":"2026100711063318900_cit1","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.aninu.2017.10.001","article-title":"Intestinal challenge with enterotoxigenic Escherichia coli in pigs, and nutritional intervention\nto prevent postweaning diarrhea","volume":"3","author":"Sun","year":"2017","journal-title":"Anim. 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