{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:43:23Z","timestamp":1792784603014,"version":"4.5.0"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["232300420195"],"award-info":[{"award-number":["232300420195"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M711058"],"award-info":[{"award-number":["2022M711058"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32603594"],"award-info":[{"award-number":["32603594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the talent foundation of Henan Agricultural University","award":["30501354"],"award-info":[{"award-number":["30501354"]}],"id":[{"id":"https:\/\/ror.org\/04eq83d71","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Key Research and Development Projects in Henan Province","award":["261111114400, 231111113200"],"award-info":[{"award-number":["261111114400, 231111113200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aflatoxins (AFs) contamination in the food chain poses a serious health threat, and current degradation strategies are limited by insufficient efficiency and stability. We developed a series of cobalt-doped CeO2 (Co@CeO2) nanozymes via a one-step hydrothermal method. The optimized nanozyme (Co-to-CeO2 mass ratio of 2:1) exhibited remarkable peroxidase-like activity, enabling efficient broad-spectrum degradation of aflatoxin B1, G1, and M1 under mild conditions, with removal efficiencies exceeding 90% in aqueous solution and approximately 80% in spiked edible oil samples. Density functional theory calculations and experimental characterization revealed that the enhanced catalytic performance originates from optimized electronic structure, abundant oxygen vacancies, and sustained reactive oxygen species generation. Notably, the nanozyme maintained over 80% degradation efficiency over six consecutive cycles, demonstrating excellent reusability. ECOSAR predictions suggested that the degradation products had reduced aquatic toxicity compared to the parent AFs. This work provides a sustainable nanozyme strategy for mycotoxin detoxification in food matrices.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c09097","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:01:45Z","timestamp":1791363705000},"page":"32205-32218","source":"Crossref","is-referenced-by-count":0,"title":["Cobalt-Doped CeO2 Nanozyme with Peroxidase-Like\nActivity for Broad-Spectrum and Recyclable Degradation of Aflatoxins"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7578-6332","authenticated-orcid":true,"given":"Hongshuai","family":"Zhu","sequence":"first","affiliation":[{"name":"Henan Agricultural University , ,","place":["Zhengzhou, China, 450002"]},{"name":"Ministry of Agriculture and Rural Affairs , , ,","place":["Zhengzhou, China, 450002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Agricultural University , ,","place":["Zhengzhou, China, 450002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Xie","sequence":"additional","affiliation":[{"name":"Henan Agricultural University , ,","place":["Zhengzhou, China, 450002"]},{"name":"Ministry of Agriculture and Rural Affairs , , ,","place":["Zhengzhou, China, 450002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Bai","sequence":"additional","affiliation":[{"name":"Henan Agricultural University , ,","place":["Zhengzhou, China, 450002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8148-7778","authenticated-orcid":true,"given":"Zhiguang","family":"Suo","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Cereal and Oil Food Safety and Nutrition , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Agricultural University , ,","place":["Zhengzhou, China, 450002"]},{"name":"Ministry of Agriculture and Rural Affairs , , ,","place":["Zhengzhou, China, 450002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Qin","sequence":"additional","affiliation":[{"name":"Henan Agricultural University , ,","place":["Zhengzhou, China, 450002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifu","family":"Ji","sequence":"additional","affiliation":[{"name":"Henan Agricultural University , ,","place":["Zhengzhou, China, 450002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"2026102109082492100_cit1","doi-asserted-by":"publisher","first-page":"138152","DOI":"10.1016\/j.seppur.2026.138152","article-title":"An ambient aqueous route to scalable ZIF-8 fabrics\nfor harmful gas capture","volume":"398","author":"Diao","year":"2026","journal-title":"Sep. Purif. Technol."},{"issue":"8","key":"2026102109082492100_cit2","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.1021\/acs.jafc.2c08148","article-title":"Biodegradation of Aflatoxin\nB1 in Peanut Oil by an Amphipathic Laccase-Inorganic Hybrid Nanoflower","volume":"71","author":"Lu","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"2026102109082492100_cit3","doi-asserted-by":"publisher","first-page":"6859","DOI":"10.1021\/acsami.2c20302","article-title":"Co-Immobilization\nof Enzymes and Metals on the Covalent-Organic Framework\nfor the Efficient Removal of Mycotoxins","volume":"15","author":"Fu","year":"2023","journal-title":"ACS\nAppl. Mater. Interfaces"},{"issue":"11","key":"2026102109082492100_cit4","doi-asserted-by":"publisher","first-page":"5966","DOI":"10.1021\/acs.jafc.3c09094","article-title":"Targeted Detoxification\nof Aflatoxin B1 in Edible Oil by an Enzyme-Metal\nNanoreactor","volume":"72","author":"Fu","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"2026102109082492100_cit5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.22358\/jafs\/194729\/2025","article-title":"Reducing aflatoxins\n(Aspergillus flavus) in food and animal feed by physical\nmethods and chemical degradation: An update","volume":"34","author":"Akhtar","year":"2025","journal-title":"J. Anim Feed Sci."},{"key":"2026102109082492100_cit6","doi-asserted-by":"publisher","first-page":"145608","DOI":"10.1016\/j.foodchem.2025.145608","article-title":"Kinetic\nanalysis of aflatoxins\u2019 degradation by persulfate anions and\nsonication","volume":"492","author":"Solomou","year":"2025","journal-title":"Food Chem."},{"key":"2026102109082492100_cit7","doi-asserted-by":"publisher","first-page":"145584","DOI":"10.1016\/j.foodchem.2025.145584","article-title":"Microbial\nand enzymatic strategies for aflatoxin control: Integrating intelligent\ndetection and computational design","volume":"492","author":"Ouyang","year":"2025","journal-title":"Food Chem."},{"key":"2026102109082492100_cit8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s40538-024-00619-4","article-title":"Investigating the\nmechanism of Bacillus amyloliquefaciens YUAD7 degrading aflatoxin\nB1 in alfalfa silage using isotope tracing and nuclear\nmagnetic resonance methods","volume":"11","author":"Tang","year":"2024","journal-title":"Chem. Biol. Technol.\nAgric."},{"issue":"22","key":"2026102109082492100_cit9","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.3390\/foods13223702","article-title":"Enzymatic\noxidation of aflatoxin M1 in milk\nusing CotA laccase","volume":"13","author":"Guo","year":"2024","journal-title":"Foods"},{"issue":"3","key":"2026102109082492100_cit10","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1111\/1541-4337.12734","article-title":"Worldwide aflatoxin\ncontamination of agricultural products and foods: From occurrence\nto control","volume":"20","author":"Jallow","year":"2026","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"48","key":"2026102109082492100_cit11","doi-asserted-by":"publisher","first-page":"2507047","DOI":"10.1002\/adfm.202507047","article-title":"Atomically\nPrecise Coinage Metal Nanoclusters with Exposed Metal Sites: Unlocking\nReactivity and Functionality","volume":"35","author":"Gupta","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"2026102109082492100_cit12","doi-asserted-by":"publisher","first-page":"104936","DOI":"10.1016\/j.tifs.2025.104936","article-title":"Optimized Cleansing\nTechniques: Engineered Covalent-Organic Frameworks (COF) Adsorbents\nfor Mycotoxin Removal from Food Products","volume":"159","author":"Mohan","year":"2025","journal-title":"Trends\nFood Sci. Technol."},{"key":"2026102109082492100_cit13","doi-asserted-by":"publisher","first-page":"145366","DOI":"10.1016\/j.foodchem.2025.145366","article-title":"Understanding the Working of Magnetic\nCOFs in the Extraction and Determination of Target Contaminants for\nFood Safety","volume":"492","author":"Mohan","year":"2025","journal-title":"Food Chem."},{"key":"2026102109082492100_cit14","doi-asserted-by":"publisher","first-page":"145906","DOI":"10.1016\/j.foodchem.2025.145906","article-title":"Improving\nperoxidase-like activity of porphyrin-based metal-organic framework\nby metal ratio tuning for detection and degradation of aflatoxin B1 in dried fruits","volume":"493","author":"Wang","year":"2025","journal-title":"Food Chem."},{"key":"2026102109082492100_cit15","doi-asserted-by":"publisher","first-page":"143334","DOI":"10.1016\/j.chemosphere.2024.143334","article-title":"Removal of\naflatoxin M1 in milk using magnetic laccase\/MoS2\/chitosan nanocomposite as an efficient sorbent","volume":"365","author":"Rezagholizade-Shirvan","year":"2024","journal-title":"Sep. Purif. Technol."},{"issue":"10","key":"2026102109082492100_cit16","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3390\/toxins17100516","article-title":"Self-sufficient\naflatoxin decontamination system: MOF-based composite membrane with\nperoxidase-mimic and controlled H2O2 generation","volume":"17","author":"Cheng","year":"2025","journal-title":"Toxins"},{"issue":"43","key":"2026102109082492100_cit17","doi-asserted-by":"publisher","first-page":"18430","DOI":"10.1021\/acs.jpcc.4c03911","article-title":"The structure, oxidation states, and energetics of\nCo nanoparticles on CeO2 (111): An STM and DFT study","volume":"128","author":"Rahman","year":"2024","journal-title":"J. Phys. Chem. C"},{"issue":"23","key":"2026102109082492100_cit18","doi-asserted-by":"publisher","first-page":"10676","DOI":"10.1021\/acs.jpcc.5c01258","article-title":"Comparison of nucleation, chemical state, and energetics\nof Ni and\nCo nanoparticles on CeO2 (111)","volume":"129","author":"Paudyal","year":"2025","journal-title":"J.\nPhys. Chem. C"},{"issue":"6","key":"2026102109082492100_cit19","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/sia.7204","article-title":"Structural, optical,\nand magnetic properties of Co-doped\nCeO2 thin films prepared by radio-frequency magnetron sputtering","volume":"55","author":"Yang","year":"2023","journal-title":"Surf. Interface Anal."},{"key":"2026102109082492100_cit20","doi-asserted-by":"publisher","first-page":"102783","DOI":"10.1016\/j.nantod.2025.102783","article-title":"Understanding the zeta potential of nanomaterials through\npredictive nanoinformatics","volume":"64","author":"Jarzynska","year":"2025","journal-title":"Nano Today"},{"issue":"1","key":"2026102109082492100_cit21","doi-asserted-by":"publisher","first-page":"19269","DOI":"10.1038\/s41598-025-04843-2","article-title":"Comparative computational and experimental\ninsights\ninto the structural, electrical, and biological properties of CeO2 fluorite ceramics","volume":"15","author":"Kumar","year":"2025","journal-title":"Sci. Rep."},{"issue":"8","key":"2026102109082492100_cit22","first-page":"4133","article-title":"Probing Nd concentration\nand annealing temperature effects on lattice\nstrain, structural and morphological properties of CeO2 nanoparticles","volume":"8","author":"Ndumiso","year":"2025","journal-title":"ACS Appl. Nano Mater."},{"key":"2026102109082492100_cit23","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1038\/s41467-021-23390-8","article-title":"Modifying\nredox properties and local bonding of Co3O4 by\nCeO2 enhances oxygen evolution\ncatalysis in acid","volume":"12","author":"Huang","year":"2021","journal-title":"Nat. Commun."},{"key":"2026102109082492100_cit24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jcis.2023.01.124","article-title":"Surface adsorbed\nand\nlattice oxygen activated by the CeO2\/Co3O4 interface for enhancive catalytic soot combustion: Experimental\nand theoretical investigations","volume":"638","author":"Huang","year":"2023","journal-title":"J. Colloid Interface\nSci."},{"key":"2026102109082492100_cit25","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.1016\/j.jre.2025.09.042","article-title":"Oxygen vacancy-rich\nCoCeO nanofiber as robust peroxymonosulfate activators for thiamethoxam\ndegradation","volume":"44","author":"Yu","year":"2025","journal-title":"J. Rare Earths"},{"key":"2026102109082492100_cit26","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/sia.2686","article-title":"Ce 3d XPS\ninvestigation of cerium oxides and mixed cerium oxide (CexTiyOz)","volume":"40","author":"Be\u0302che","year":"2008","journal-title":"Surf. Interface Anal."},{"issue":"32","key":"2026102109082492100_cit27","doi-asserted-by":"publisher","first-page":"16203","DOI":"10.1021\/acs.analchem.5c01219","article-title":"Synthesis\nof Co\/Ce dual active sites single-atom cerium nanozyme with the synergistic\neffect and peroxidase-like activity for total antioxidant capacity\nevaluation","volume":"97","author":"Guo","year":"2025","journal-title":"Anal. Chem."},{"key":"2026102109082492100_cit28","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1007\/s00216-022-04100-9","article-title":"CeO2\/Co3O4@N-doped hollow carbon microspheres\nwith improved peroxidase-like\nactivity for the determination of quercetin","volume":"416","author":"Han","year":"2025","journal-title":"Anal. Bioanal. Chem."},{"issue":"21","key":"2026102109082492100_cit29","doi-asserted-by":"publisher","first-page":"26182","DOI":"10.1021\/acs.est.5c14046","article-title":"Cascaded Fe-*OOH\nand Co-*H 2 O 2 Intermediates on Fe\u2013Co Dual Sites for Orchestrated\nO 2 3-Electron Electro-Fenton Pathways","volume":"59","author":"Zhang","year":"2025","journal-title":"Environ.\nSci. Technol."},{"issue":"10","key":"2026102109082492100_cit30","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1002\/elan.202100249","article-title":"Oxygen-vacancy-enhanced\nCatalytic Activity of Au@Co 3 O 4 \/CeO 2\nYolk-shell Nanocomposite to Electrochemically Detect Hydrogen Peroxide","volume":"33","author":"Lei","year":"2021","journal-title":"Electroanalysis"},{"key":"2026102109082492100_cit31","doi-asserted-by":"publisher","first-page":"167927","DOI":"10.1016\/j.cej.2025.167927","article-title":"Molten salt in situ reconstruction\nrealizes ultrafast charge transfer at cobalt-doped-CeO2\/CeO2 S-scheme interface for photocatalytic H2O2 production","volume":"522","author":"Lin","year":"2025","journal-title":"Chem. Eng. J."},{"key":"2026102109082492100_cit32","doi-asserted-by":"publisher","first-page":"105135","DOI":"10.1016\/j.tifs.2025.105135","article-title":"Synergic removal of aflatoxin B1 in oily\nmatrices by focusing on the peroxidase-like nanozymes-driven strategies:\nMechanisms and intermediate toxicity, nutritional impact, advances\nand challenges","volume":"163","author":"Faraji","year":"2025","journal-title":"Trends Food Sci. Technol."},{"issue":"1","key":"2026102109082492100_cit33","first-page":"420","article-title":"A SERS-based\nimmunoassay\nwith CeO2 nanozyme as a signal amplification tag for the\ndetection of aflatoxin B1","volume":"70","author":"Ye","year":"2022","journal-title":"J. Agric.\nFood Chem."},{"issue":"9","key":"2026102109082492100_cit34","doi-asserted-by":"publisher","first-page":"11809","DOI":"10.1021\/acsami.3c18878","article-title":"Fe-Co-based metal-organic frameworks as peroxidase mimics for sensitive\ncolorimetric detection and efficient degradation of aflatoxin B1","volume":"16","author":"Lin","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026102109082492100_cit35","doi-asserted-by":"publisher","first-page":"145608","DOI":"10.1016\/j.foodchem.2025.143807","article-title":"A simple post-processing approach\ninduced interface recombination to construct hollow cubic-shape Prussian\nblue analogs for biosensing and degradation of aflatoxins B1","volume":"512","author":"Wang","year":"2026","journal-title":"Food Chem."},{"issue":"3","key":"2026102109082492100_cit36","first-page":"182","article-title":"Comprehensive\nstudy on the electronic structure and\nreactivity of aflatoxins B1, B2, G1 and G2 using density functional theory","volume":"15","author":"Sklena\u0301r\u030c","year":"2023","journal-title":"Toxins"},{"key":"2026102109082492100_cit37","first-page":"142962","article-title":"Exploring of Cutannic\nacid laccasemimicking nanozyme for effective degradation of aflatoxin\nB1","volume":"495","author":"Liu","year":"2025","journal-title":"Food Chem"}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c09097","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/41\/32205\/68766796\/acs.jafc.6c09097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/41\/32205\/68766796\/acs.jafc.6c09097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:30:04Z","timestamp":1792589404000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/41\/32205\/5445830\/Cobalt-Doped-CeO2-Nanozyme-with-Peroxidase-Like"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":37,"journal-issue":{"issue":"41","published-online":{"date-parts":[[2026,10,7]]},"published-print":{"date-parts":[[2026,10,21]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c09097","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}