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Phytochemical investigation of its rhizomes yielded 33 terpenoids, of which 12 are previously undescribed compounds, comprising both diterpenes and sesquiterpenes. Notably, compound 1 represents a rare, highly oxygenated isospongiane-type diterpenoid with a novel skeleton. The anti-inflammatory potential of all isolates was assessed using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and BV2 microglial cells. Subsequent mechanism-oriented assays demonstrated that compounds 2 and 4 attenuated neuroinflammation in BV2 cells through an effect attributable to inhibition of nuclear factor kappa-B (NF-\u03baB) nuclear translocation, reduction of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and signal transducer and activator of transcription 3 (STAT3) protein expression, and downregulation of the mRNA levels of iNOS, interleukin-1\u03b2 (IL-1\u03b2), COX-2, and tumor necrosis factor-\u03b1 (TNF-\u03b1).<\/jats:p>","DOI":"10.1021\/acs.jafc.6c09118","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:20:30Z","timestamp":1788452430000},"page":"27138-27156","source":"Crossref","is-referenced-by-count":0,"title":["Anti-inflammatory\nDiterpenoids and Sesquiterpenoids\nfrom the Rhizomes of Shell Ginger (\n                    <i>Alpinia zerumbet<\/i>\n                    )"],"prefix":"10.1021","volume":"74","author":[{"given":"Jinghui","family":"Wu","sequence":"first","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyang","family":"Guan","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-532X","authenticated-orcid":true,"given":"Yihai","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-7657","authenticated-orcid":true,"given":"Xiangjiu","family":"He","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"7","key":"2026090311502196200_cit1","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1021\/jf104813k","article-title":"HIV-1 integrase\nand neuraminidase inhibitors from Alpinia zerumbet","volume":"59","author":"Upadhyay","year":"2011","journal-title":"J. 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Synthesis of (+)-5\u03b2H-eudesma-3,\n11-diene,(\u2212)-5\u03b2H-eudesmane-4\u03b2, 11-diol, and (+)-5\u03b2H-eudesmane-4\u03b1,\n11-diol, and structure revision of a natural eudesmane-4, 11-diol\nisolated from Pluchea arguta","volume":"57","author":"Ando","year":"1994","journal-title":"J. Nat. Prod."},{"issue":"1","key":"2026090311502196200_cit43","doi-asserted-by":"publisher","first-page":"047","DOI":"10.2306\/scienceasia1513-1874.1985.11.047","article-title":"Traditional\nmedicinal plants of Thailand VI. isolation of cryptomeridiol from\nBlumea balsamifera","volume":"11","author":"Ruangrungsi","year":"1985","journal-title":"ScienceAsia"},{"issue":"11","key":"2026090311502196200_cit44","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1021\/np960419w","article-title":"Sesquiterpenes from\nBaeckea frutescens","volume":"59","author":"Tsui","year":"1996","journal-title":"J. Nat. 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