{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:49:59Z","timestamp":1791391799834,"version":"4.3.3"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024250","name":"Israel Innovation Authority","doi-asserted-by":"publisher","award":["82552"],"award-info":[{"award-number":["82552"]}],"id":[{"id":"10.13039\/501100024250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The high cost of growth factors has limited the commercial-scale production of cultivated meat products. In this study, we report on the synthesis and characterization of a series of naringin phenolate salts. Phenolate salts with sodium (Na+), potassium (K+), calcium (Ca2+), and tetrabutylammonium (TBA+) counterions were prepared to introduce water solubility to the natural flavonoid naringin. The synthesized salts were comprehensively characterized to confirm their chemical structures. Solvated cations were examined for their effect on the salts\u2019 physicochemical and biological properties. Solubility studies show that alkali metal salts are highly soluble in water, while the Ca2+ and TBA+ salts are less soluble. Acid regeneration studies confirm the reversibility of the salt formation. Preliminary studies indicate that selected naringin salts may support cell proliferation in cultivated meat systems. Overall, this study presents the first comprehensive report on naringin phenolate salts and their potential use in cultivated meat production.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c09167","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:02:38Z","timestamp":1790236958000},"page":"31127-31136","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Characterization\nof Naringin Phenolate\nSalts for Cultivated Meat"],"prefix":"10.1021","volume":"74","author":[{"given":"Matilda","family":"Dirawy","sequence":"first","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6882-9774","authenticated-orcid":true,"given":"Muhammad","family":"Abdel-Haq","sequence":"additional","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Hasenson","sequence":"additional","affiliation":[{"name":"SuperMeat Co., The Essence of Meat Ltd , Pinhas Sapir 3 , ,","place":["Nes Ziona, Israel, 7403626"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mahajna","sequence":"additional","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mahameed","sequence":"additional","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5606-401X","authenticated-orcid":true,"given":"M. N. V. Ravi","family":"Kumar","sequence":"additional","affiliation":[{"name":"The University of Alabama , , , ,","place":["Tuscaloosa, Alabama, United States, 35401"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-3153","authenticated-orcid":true,"given":"Meenakshi","family":"Arora","sequence":"additional","affiliation":[{"name":"The University of Alabama , , , ,","place":["Tuscaloosa, Alabama, United States, 35401"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-7726","authenticated-orcid":true,"given":"Abraham J.","family":"Domb","sequence":"additional","affiliation":[{"name":"The Hebrew University of Jerusalem , , ,","place":["Jerusalem, Israel, 91120"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"issue":"5","key":"2026100711071834300_cit1","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.5958\/0974-360X.2020.00447.3","article-title":"Naringin: Sources,\nChemistry, Toxicity, Pharmacokinetics, Pharmacological Evidences,\nMolecular Docking and Cell Line Study","volume":"13","author":"Alam","year":"2020","journal-title":"Res.\nJ. Pharm. Technol."},{"issue":"3","key":"2026100711071834300_cit2","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1111\/1541-4337.13129","article-title":"A Comprehensive Review of the Metabolism\nof Citrus Flavonoids and Their Binding to Bitter Taste Receptors","volume":"22","author":"Li","year":"2023","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"5","key":"2026100711071834300_cit3","doi-asserted-by":"publisher","first-page":"341","DOI":"10.12691\/jfnr-3-5-9","article-title":"Citrus Flavonoids and Human Cancers","volume":"3","author":"Ke","year":"2015","journal-title":"J. Food Nutr.\nRes."},{"key":"2026100711071834300_cit4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-94753-8_29-1","article-title":"Advances on\nResources, Biosynthesis Pathway, Bioavailability, Bioactivity, and\nPharmacology","volume-title":"Handbook of Dietary Flavonoids","author":"Ribeiro","year":"2023"},{"key":"2026100711071834300_cit5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3390\/nu5030637","article-title":"Naringin Improves Diet-Induced Cardiovascular\nDysfunction and Obesity in High Carbohydrate, High Fat Diet-Fed Rats","volume":"5","author":"Alam","year":"2013","journal-title":"Nutrients"},{"issue":"1","key":"2026100711071834300_cit6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/foods10010003","article-title":"Preliminary Techno-Economic Assessment of Animal Cell-Based\nMeat","volume":"10","author":"Risner","year":"2021","journal-title":"Foods"},{"issue":"5","key":"2026100711071834300_cit7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/antiox8050137","article-title":"Dietary Flavonoids\nas Cancer Chemopreventive Agents: An Updated Review of Human Studies","volume":"8","author":"Rodri\u0301guez-Garci\u0301a","year":"2019","journal-title":"Antioxidants"},{"issue":"1","key":"2026100711071834300_cit8","doi-asserted-by":"publisher","first-page":"100012","DOI":"10.1016\/j.crsus.2023.100012","article-title":"Cultured\nMeat Production\u2500Scale and Quality","volume":"1","author":"Young","year":"2024","journal-title":"Cell\nRep. 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Food Saf."},{"issue":"4","key":"2026100711071834300_cit12","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1002\/bit.28324","article-title":"Techno-economic\nModeling and Assessment\nof Cultivated Meat: Impact of Production Bioreactor Scale","volume":"120","author":"Negulescu","year":"2023","journal-title":"Biotechnol. Bioeng."},{"key":"2026100711071834300_cit13","doi-asserted-by":"publisher","first-page":"104584","DOI":"10.1016\/j.phrs.2019.104584","article-title":"Advances on Natural Polyphenols as\nAnticancer Agents for Skin Cancer","volume":"151","author":"Sajadimajd","year":"2020","journal-title":"Pharmacol.\nRes."},{"key":"2026100711071834300_cit14","doi-asserted-by":"publisher","first-page":"1669909","DOI":"10.3389\/fnut.2025.1669909","article-title":"Toward FGF2\nReduction\nin Cultured Meat Media: Polyphenol Salts Enhance Growth and Differentiation\nof bESC Aggregates","volume":"12","author":"Savyon","year":"2025","journal-title":"Front. Nutr."},{"issue":"11","key":"2026100711071834300_cit15","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.3390\/antibiotics11111628","article-title":"Naringenin and Its Derivatives\u2500Health-Promoting\nPhytobiotic against Resistant Bacteria and Fungi in Humans","volume":"11","author":"Duda-Madej","year":"2022","journal-title":"Antibiotics"},{"issue":"3","key":"2026100711071834300_cit16","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1021\/je501004g","article-title":"Solubilities\nof Naringin\nand Naringenin in Different Solvents and Dissociation Constants of\nNaringenin","volume":"60","author":"Zhang","year":"2015","journal-title":"J. Chem. Eng. Data"},{"key":"2026100711071834300_cit17","doi-asserted-by":"publisher","first-page":"121846","DOI":"10.1016\/j.jchromb.2019.121846","article-title":"Tissue Distribution\nof Naringin and Derived Metabolites\nin Rats after a Single Oral Administration","volume":"1136","author":"Zeng","year":"2020","journal-title":"J. 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Chem."},{"key":"2026100711071834300_cit22","unstructured":"Domb, A. J.; Steinman, N.; Rottenberg, Y.\n          Bioactive Phenolate\nIonic Complexes, 2021WO 2,021,214,762\nA1."},{"key":"2026100711071834300_cit23","volume-title":"Organic Chemistry:\nstudy Guide and Solutions Manual","author":"Bruice","year":"2017","edition":"8th"},{"key":"2026100711071834300_cit24","doi-asserted-by":"publisher","first-page":"111236","DOI":"10.1016\/j.fct.2020.111236","article-title":"The GRAS Provision - The FEMA GRAS\nProgram and the Safety and Regulation of Flavors in the United States","volume":"138","author":"Hallagan","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"8","key":"2026100711071834300_cit25","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1080\/10408398.2020.1756217","article-title":"Ten Years Post-GAO\nAssessment, FDA Remains Uninformed of Potentially Harmful GRAS Substances\nin Foods","volume":"61","author":"Faustman","year":"2021","journal-title":"Crit. Rev. 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