{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:57:11Z","timestamp":1791388631194,"version":"4.3.3"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Science and Technology Project in Guangzhou","award":["202102070001"],"award-info":[{"award-number":["202102070001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The crude anthocyanin extract isolated from cranberry (Vaccinium macrocarpon Aiton) was enzymatically acylated with fatty acids of varying chain lengths using Novozyme 435 (Candida antarctica lipase B immobilized on acrylic resin). After optimization, the highest acylation rates of 65.72% and 70.64% for cyanidin-3-O-galactoside and peonidin-3-O-galactoside, respectively, were obtained by acylating with octanoic acid under the conditions of lipase dosage of 10 mg\/mL, molar ratio of 1:418, at 50 \u00b0C for 30 h in 2-methyl-2-butanol. Acylated anthocyanins with high purity (&amp;gt;97%) were obtained through liquid\u2013liquid extraction and medium-pressure liquid chromatography and identified as cyanidin-3-O-(6\u2033-octanoyl) galactoside and peonidin-3-O-(6\u2033-octanoyl) galactoside by MS\/MS and 2D NMR. The acylated cranberry anthocyanins exhibited enhanced lipophilicity, photostability, thermostability, and excellent antioxidant activity in both aqueous and lipid systems. These findings demonstrate enzymatic acylation in a crude anthocyanin matrix and provide insights into acylation-induced structure\u2013property relationships, supporting the rational development of functionalized anthocyanins from natural extracts.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c09306","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:01:42Z","timestamp":1790607702000},"page":"30870-30884","source":"Crossref","is-referenced-by-count":0,"title":["Enzymatic Acylation\nof Cranberry (\n                    <i>Vaccinium macrocarpon<\/i>\n                    Aiton) Anthocyanins with Fatty Acid: Improvement\nof Stability, Lipophilicity, and Antioxidant Capacity"],"prefix":"10.1021","volume":"74","author":[{"given":"Zhang","family":"Huang","sequence":"first","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]},{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]},{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Dong","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]},{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong University of Technology , , , ,","place":["Guangzhou, Guangdong, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayang","family":"Xu","sequence":"additional","affiliation":[{"name":"Hisense Ronshen (Guangdong) Refrigerator Co., Ltd. , , ,","place":["Foshan, Guangdong, China, 528300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Chang","sequence":"additional","affiliation":[{"name":"Hisense Ronshen (Guangdong) Refrigerator Co., Ltd. , , ,","place":["Foshan, Guangdong, China, 528300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]},{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-2970","authenticated-orcid":true,"given":"Weibin","family":"Bai","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]},{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026100711064474800_cit1","doi-asserted-by":"publisher","first-page":"138778","DOI":"10.1016\/j.foodchem.2024.138778","article-title":"A new UHPLC-HRMS\nmetabolomics approach for the rapid and comprehensive analysis of\nphenolic compounds in blueberry, raspberry, blackberry, cranberry\nand cherry fruits","volume":"445","author":"Kodikara","year":"2024","journal-title":"Food Chem."},{"key":"2026100711064474800_cit2","doi-asserted-by":"publisher","first-page":"101734","DOI":"10.1016\/j.fochx.2024.101734","article-title":"Comprehensive\nstructural analysis of anthocyanins in blue honeysuckle (Lonicera\ncaerulea L.), bilberry (Vaccinium uliginosum L.), cranberry (Vaccinium\nmacrocarpon Ait.), and antioxidant capacity comparison","volume":"23","author":"Guo","year":"2024","journal-title":"Food Chem.:X"},{"issue":"49","key":"2026100711064474800_cit3","doi-asserted-by":"publisher","first-page":"9342","DOI":"10.1021\/acs.jafc.6b04291","article-title":"Phenolics of selected\ncranberry genotypes (Vaccinium macrocarpon Ait.) and their antioxidant\nefficacy","volume":"64","author":"Abeywickrama","year":"2016","journal-title":"J. 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