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To address this challenge, we developed a multifunctional hydrogel based on natural polymer. Specifically, an ROS-responsive hydrogel was fabricated via dynamic boronate ester bonds between phenylboronic acid-functionalized pectin (Pe-PBA) and poly(vinyl alcohol) (PVA), then loaded with Ganoderma atrum polysaccharide (PSG), termed Pe\/PVA@PSG. The obtained hydrogel exhibited excellent mechanical properties and self-healing ability, enabling efficient PSG release triggered in response to high-glucose and -ROS conditions. In vitro, it showed excellent biocompatibility, significantly facilitated fibroblast proliferation and migration, and suppressed ROS accumulation and macrophage inflammatory responses. In a diabetic wound model, Pe\/PVA@PSG markedly accelerated wound closure, achieving 93.42% closure on day 14, which enhanced collagen deposition and skin appendage regeneration, elevated IL-10, upregulated PD-L1, and drove macrophage polarization toward the M2 phenotype. Overall, the Pe\/PVA@PSG hydrogel provides an innovative strategy for chronic diabetic wound management.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c09422","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:02:03Z","timestamp":1790625723000},"page":"30897-30910","source":"Crossref","is-referenced-by-count":0,"title":["A ROS-Responsive Pectin\/PVA Hydrogel Loaded with\n                    <i>Ganoderma atrum<\/i>\n                    Polysaccharide Accelerates Diabetic Wound\nHealing by Polarizing Macrophages toward the M2 Phenotype"],"prefix":"10.1021","volume":"74","author":[{"given":"Leyi","family":"Wei","sequence":"first","affiliation":[{"name":"Nanchang University , , 235 Nanjing East Road , ,","place":["Nanchang, China, 330047"]},{"name":"Nanchang University , , ,","place":["Nanchang, China, 330052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fansen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Li","sequence":"additional","affiliation":[{"name":"Nanchang University , , 235 Nanjing East Road , ,","place":["Nanchang, China, 330047"]},{"name":"Nanchang University , , ,","place":["Nanchang, China, 330052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Yao","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine , , ,","place":["Nanchang, China, 330006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqiao","family":"Li","sequence":"additional","affiliation":[{"name":"Nanchang University , , 235 Nanjing East Road , ,","place":["Nanchang, China, 330047"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5191-5601","authenticated-orcid":true,"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[{"name":"Nanchang University , , 235 Nanjing East Road , ,","place":["Nanchang, China, 330047"]},{"name":"Nanchang University , , ,","place":["Nanchang, China, 330052"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"10397","key":"2026100711070430400_cit1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, Regional, and National Burden of Diabetes from 1990 to 2021,\nwith Projections of Prevalence to 2050: A Systematic Analysis for\nthe Global Burden of Disease Study 2021","volume":"402","author":"GBD 2021 Diabetes Collaborators.","year":"2023","journal-title":"Lancet"},{"issue":"15","key":"2026100711070430400_cit2","doi-asserted-by":"publisher","first-page":"17469","DOI":"10.1021\/acsanm.4c02558","article-title":"Hydrogel with\nROS Scavenging and Photothermal Sterilizing\nActivity for Treatment of Diabetic Wound Healing","volume":"7","author":"Cheng","year":"2024","journal-title":"ACS Appl. 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