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In this study, catechol moieties were incorporated into G2-class fungicidal scaffolds to prepare a series of siderophores. At 50 \u03bcg\/mL, the compounds PP-3 and PPDM-2 achieved mean inhibition rates (MIRs) of 64.0% and 67.2%, respectively, against 11 plant pathogens, comparable to tridemorph (64.6%). However, the two compounds exhibited distinct activity spectra. PP-3 and PPDM-2 showed strong activity against two oomycete pathogens (Pythium aphanidermatum and Phytophthora capsici) and Fusarium graminearum, suggesting potential for crop disease management. Preliminary assays indicated disruption of Fe3+\/Fe2+ homeostasis and rapid ion leakage through nonspecific membrane lipid perturbation; inhibition of ergosterol biosynthesis may additionally contribute to activity against fungi. These findings support the development of agricultural fungicides incorporating functional iron-chelating moieties.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c09445","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:01:42Z","timestamp":1790942502000},"page":"31503-31518","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Fungicidal Activity, and Action Mode of\nFunctionalized Siderophores"],"prefix":"10.1021","volume":"74","author":[{"given":"Minghui","family":"Chen","sequence":"first","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Hong","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6606-2074","authenticated-orcid":true,"given":"Xuemin","family":"Wu","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Hou","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Xiao","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8352-9393","authenticated-orcid":true,"given":"Bin","family":"Fu","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-2543","authenticated-orcid":true,"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7516-2432","authenticated-orcid":true,"given":"Zhaohai","family":"Qin","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"issue":"4","key":"2026101408094294800_cit1","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/j.1364-3703.2011.00783.x","article-title":"The Top\n10 Fungal Pathogens\nin Molecular Plant Pathology","volume":"13","author":"Dean","year":"2012","journal-title":"Mol. 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