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Proteolysis of MSRC was enhanced, as indicated by its higher hydrolysis indices compared to those of CRC (P &amp;lt; 0.05). The &amp;lt;3 kDa WSP fraction from MSRC had stronger antioxidant activity than those from PRC and MRC (P &amp;lt; 0.05). The fraction also had higher \u03b1-glucosidase inhibitory activity (66.19%) and xanthine oxidase inhibitory activity (56.07%) than CRC (P &amp;lt; 0.05). LC\u2013MS\/MS identified 2521 peptides in MSRC. 1196 peptides were shared among all cheeses, and 157 were unique to MSRC. Among these, nine characteristic active peptides (e.g., AWPQYLK and FPGPIP) are predicted to exert effects mainly by binding to receptor proteins via hydrogen bonding and hydrophobic interactions. These results highlight MSRC\u2019s potential as a viable alternative to rennet.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c09729","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:02:26Z","timestamp":1787072546000},"page":"26441-26454","source":"Crossref","is-referenced-by-count":0,"title":["Effect of\n                    <i>Moringa oleifera<\/i>\n                    Seeds\nRennet on the Quality of Mozzarella Cheese and Proteomic Identification\nand Molecular Docking Analysis of Fermentation-Derived Peptides"],"prefix":"10.1021","volume":"74","author":[{"given":"Yaozhu","family":"Fan","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University , ,","place":["Kunming, P. R. 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China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqiang","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University , ,","place":["Kunming, P. R. China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shi","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Kunming Medical University , , ,","place":["Kunming, P. R. China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangping","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University , ,","place":["Kunming, P. R. 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