{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:04:33Z","timestamp":1789567473108,"version":"build-2803163510"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"Beijing Life Science Academy Foundation","doi-asserted-by":"publisher","award":["No. 2023600CA0080"],"award-info":[{"award-number":["No. 2023600CA0080"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 32202217"],"award-info":[{"award-number":["No. 32202217"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 32372463"],"award-info":[{"award-number":["No. 32372463"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ethanol-induced gastric mucosal injury (AGMI) is intrinsically linked to oxidative stress, inflammatory responses, and compromised mucosal defense. This study aimed to isolate bioactive peptides from yeast protein (YP) and elucidate these in vitro protective mechanisms against AGMI. Activity-guided multi-technique separation, nanoLC-MS\/MS, and bioinformatic screening were used to identify two novel peptides, ISPALLDKL and TAADLRYF. In ethanol-injured GES-1 cells, these peptides (240 and 320 \u03bcg\/mL) exhibited potent cytoprotective activity comparable to omeprazole. Peptide pre-treatment attenuated reactive oxygen species (from 31.79 to 9.52 and 10.02), restored mitochondrial membrane potential (\u0394\u03a8m increased from 0.5 to 2.78 and 2.11), and reduced apoptosis (from 28.55 to 10.52% and 12.58%). Furthermore, these peptides associated with the suppression of pro-inflammatory cytokines, decreasing TNF-\u03b1 (24.9 and 21.9%), IL-1\u03b2 (30.1 and 26.3%), and IL-6 (41.9 and 37.6%), while markedly enhancing the anti-inflammatory cytokine IL-10 (110.8 and 91.0%), respectively; these effects were accompanied by inhibition of NF-\u03baB and JAK2\u2013STAT3 phosphorylation. Collectively, ISPALLDKL and TAADLRYF protect against ethanol-induced gastric epithelial cell injury by simultaneously modulating oxidative stress, apoptosis, and inflammation, positioning them as promising natural candidates for gastric mucosal protection.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c09805","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:02:03Z","timestamp":1788573723000},"page":"28526-28541","source":"Crossref","is-referenced-by-count":0,"title":["Yeast Protein-Derived\nPeptides Protect against Ethanol-Induced\nAcute Gastric Mucosal Injury: Isolation, Identification, and Potential\nMechanisms"],"prefix":"10.1021","volume":"74","author":[{"given":"Jin","family":"Luo","sequence":"first","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaina","family":"Qiao","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhao","family":"Bi","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xialei","family":"Liu","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Yin","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy (BLSA) , ,","place":["Beijing, China, 102209"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoguo","family":"Sun","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-1115","authenticated-orcid":true,"given":"Li","family":"Liang","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]},{"name":"Beijing Technology and Business University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"2026091609083773500_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110649","article-title":"In vivo and In silico\nevidence of the protective properties of carvacrol against experimentally-induced\ngastric ulcer: Implication of antioxidant, anti-inflammatory, and\nantiapoptotic mechanisms","volume":"382","author":"Badr","year":"2023","journal-title":"Chem.-Biol. Interact."},{"key":"2026091609083773500_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2023.103371","article-title":"Sulfated iota-carrageenan from marine\nalga Agardhiella ramosissima prevents gastric injury in rodents via\nits antioxidant properties","volume":"77","author":"Pinheiro","year":"2024","journal-title":"Algal Res."},{"key":"2026091609083773500_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123473","article-title":"Polystyrene\nmicroplastic-induced\noxidative stress triggers intestinal barrier dysfunction via the NF-\u03baB\/NLRP3\/IL-1\u03b2\/MCLK\npathway","volume":"345","author":"Zeng","year":"2024","journal-title":"Environ. Pollut."},{"issue":"6","key":"2026091609083773500_cit4","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061263","article-title":"Metabolites\nProfiling\nand Bioassays Reveal Bassia indica Ethanol Extract Protective Effect\nagainst Stomach Ulcers Development via HMGB1\/TLR-4\/NF-\u03baB Pathway","volume":"12","author":"El-Gendy","year":"2023","journal-title":"Antioxidants"},{"key":"2026091609083773500_cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116986","article-title":"Gastroprotective effect of eupatilin, a polymethoxyflavone\nfrom Artemisia argyi H.L\u2019ev. & Vaniot, in ethanol-induced\ngastric mucosal injury via NF-?B signaling pathway","volume":"318","author":"Du","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"2026091609083773500_cit6","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111836","article-title":"Commiphora\nmyrrh Supplementation Protects and Cures Ethanol-Induced Oxidative\nAlterations of Gastric Ulceration in Rats","volume":"10","author":"Lebda","year":"2021","journal-title":"Antioxidants"},{"key":"2026091609083773500_cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111490","article-title":"Mechanism of rutaecarpine on ethanol-induced\nacute gastric ulcer using integrated metabolomics and network pharmacology","volume":"138","author":"Ren","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"17","key":"2026091609083773500_cit8","doi-asserted-by":"publisher","first-page":"7664","DOI":"10.1039\/D1FO00911G","article-title":"Glycopeptides from\nPaecilomyces sinensis ameliorate ethanol-induced gastric ulcers via\nanti-inflammation and the miR-9-5p-MEK\/ERK signaling pathway","volume":"12","author":"Zhou","year":"2021","journal-title":"Food Funct."},{"issue":"1","key":"2026091609083773500_cit9","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010257","article-title":"pH-Responsive Hydrogel\nas a Potential Oral Delivery\nSystem of Baicalin for Prolonging Gastroprotective Activity","volume":"15","author":"Xu","year":"2023","journal-title":"Pharmaceutics"},{"key":"2026091609083773500_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116972","article-title":"Antiulcer activity and mechanism of action of the hydroethanolic\nextract of leaves of Terminalia argentea Mart. In different in vivo\nand in vitro experimental models","volume":"318","author":"Venturini","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"2026091609083773500_cit11","doi-asserted-by":"publisher","first-page":"881","DOI":"10.2174\/1381612013397645","article-title":"New issues about nitric oxide and\nits effects on the gastrointestinal tract","volume":"7","author":"Marti\u0301n","year":"2001","journal-title":"Curr.\nPharm. Des."},{"issue":"5","key":"2026091609083773500_cit12","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/jemt.1100","article-title":"Nitric\noxide: Relation to integrity,\ninjury, and healing of the gastric mucosa","volume":"53","author":"Calatayud","year":"2001","journal-title":"Microsc.\nRes. Tech."},{"issue":"6","key":"2026091609083773500_cit13","doi-asserted-by":"publisher","first-page":"783","DOI":"10.5009\/gnl250267","article-title":"Pharmacological\nTreatment of Gastritis: A Narrative Review with a Systematic Literature\nSearch","volume":"19","author":"Kim","year":"2025","journal-title":"Gut Liver"},{"issue":"24","key":"2026091609083773500_cit14","doi-asserted-by":"publisher","DOI":"10.3390\/foods13244178","article-title":"Identification of Protein\nHydrolysates from Sesame Meal and In Vivo Study of Their Gastric Mucosal\nProtective Effects","volume":"13","author":"Yuan","year":"2024","journal-title":"Foods"},{"issue":"4","key":"2026091609083773500_cit15","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041138","article-title":"The Gastroprotective\nEffect of Small Molecule Oligopeptides Isolated from Walnut (Juglans\nregia L.) against Ethanol-Induced Gastric Mucosal Injury in Rats","volume":"12","author":"Liu","year":"2020","journal-title":"Nutrients"},{"issue":"23","key":"2026091609083773500_cit16","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234866","article-title":"The Gastroprotective\nEffect of Walnut\nPeptides: Mechanisms and Impact on Ethanol-Induced Acute Gastric Mucosal\nInjury in Mice","volume":"15","author":"Yuan","year":"2023","journal-title":"Nutrients"},{"issue":"49","key":"2026091609083773500_cit17","doi-asserted-by":"publisher","first-page":"14985","DOI":"10.1021\/acs.jafc.1c07050","article-title":"Tricholoma\nmatsutake-Derived Peptides Show Gastroprotective Effects against Ethanol-Induced\nAcute Gastric Injury","volume":"69","author":"Li","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"2026091609083773500_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104271","article-title":"Wheat peptide protects against ethanol-induced\ngastric mucosal damage through downregulation of TLR4 and MAPK","volume":"75","author":"Yang","year":"2020","journal-title":"J. Funct. Foods"},{"issue":"5","key":"2026091609083773500_cit19","doi-asserted-by":"publisher","DOI":"10.1002\/efd2.70004","article-title":"Tricholoma\nmatsutake heptapeptide prevents gastric mucosa injury by regulating\noxidative stress-related mitochondrial function and mucous layer integrity","volume":"5","author":"Lv","year":"2024","journal-title":"Efood"},{"issue":"48","key":"2026091609083773500_cit20","doi-asserted-by":"publisher","first-page":"18722","DOI":"10.1021\/acs.jafc.3c01764","article-title":"Val-Leu-Leu-Tyr\n(VLLY) Alleviates Ethanol-Induced Gastric Mucosal Cell Impairment\nby Improving Mitochondrial Fission","volume":"71","author":"Zheng","year":"2023","journal-title":"J. Agric.\nFood Chem."},{"key":"2026091609083773500_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104748","article-title":"Comparing\nnutritional and digestibility aspects of\nsustainable proteins using the INFOGEST digestion protocol","volume":"87","author":"Arie\u0308ns","year":"2021","journal-title":"J. Funct. Foods"},{"issue":"18","key":"2026091609083773500_cit22","doi-asserted-by":"publisher","DOI":"10.3390\/su12187704","article-title":"Rye and Oat\nAgricultural Wastes as Substrate Candidates for Biomass Production\nof the Non-Conventional Yeast Yarrowia lipolytica","volume":"12","author":"Drzyma\u0142a","year":"2020","journal-title":"Sustainability"},{"key":"2026091609083773500_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.735885","article-title":"Single cell protein: Sources, mechanism of production,\nnutritional value and its uses in aquaculture nutrition","volume":"531","author":"Sharif","year":"2021","journal-title":"Aquaculture"},{"key":"2026091609083773500_cit24","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.tifs.2023.04.003","article-title":"Yeast proteins: The\nnovel and sustainable alternative protein in\nfood applications","volume":"135","author":"Ma","year":"2023","journal-title":"Trends Food Sci. Technol."},{"key":"2026091609083773500_cit25","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.ijbiomac.2022.03.094","article-title":"Spent brewer\u2019s\nyeast (Saccharomyces cerevisiae) as a potential source of bioactive\npeptides: An overview","volume":"208","author":"Oliveira","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"2026091609083773500_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.107850","article-title":"Yeast protein hydrolysates alleviate\nethanol-induced gastric mucosal injury via modulation of the NF-\u03baB\/AMPK\nsignaling pathway","volume":"74","author":"Qiao","year":"2025","journal-title":"Food Biosci."},{"issue":"2","key":"2026091609083773500_cit27","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4149\/gpb_2018035x","article-title":"Anti-oxidant and anti-inflamatuar effectiveness of caftaric acid\non gastric ulcer induced by indomethacin in rats","volume":"38","author":"Tanyeli","year":"2019","journal-title":"Gen. Physiol. Biophys."},{"issue":"6","key":"2026091609083773500_cit28","doi-asserted-by":"publisher","first-page":"7133","DOI":"10.1007\/s00210-024-03733-0","article-title":"Assessment of sinapic acid\u2019s protective effects\nagainst ethanol-induced gastric ulcers in rats","volume":"398","author":"Akdemir","year":"2025","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"38","key":"2026091609083773500_cit29","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.3748\/wjg.14.5857","article-title":"Oxidative stress\ndisturbs energy metabolism of mitochondria in ethanol-induced gastric\nmucosa injury","volume":"14","author":"Pan","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"2026091609083773500_cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.141634","article-title":"ACE inhibitory effect and saltiness-enhancing\nproperties of chicken-derived umami peptides: Digestive stability,\ninhibition kinetics, multiple ligand docking and central composite\ndesign","volume":"464","author":"Zhang","year":"2025","journal-title":"Food Chem."},{"issue":"2","key":"2026091609083773500_cit31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1751-2980.2011.00480.x","article-title":"Acetaldehyde\nand gastric cancer","volume":"12","author":"Salaspuro","year":"2011","journal-title":"J. Dig. Dis."},{"issue":"2","key":"2026091609083773500_cit32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3164\/jcbn.13-32","article-title":"Alcohol is an oxidative\nstressor for gastric epithelial cells: detection of superoxide in\nliving cells","volume":"53","author":"Tamura","year":"2013","journal-title":"J. Clin. Biochem. Nutr."},{"key":"2026091609083773500_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.108941","article-title":"Lipid peroxidation\nas measured by chromatographic determination\nof malondialdehyde. Human plasma reference values in health and disease","volume":"709","author":"Mas-Bargues","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"2026091609083773500_cit34","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several lines of antioxidant\ndefense\nagainst oxidative stress: antioxidant enzymes, nanomaterials with\nmultiple enzyme-mimicking activities, and low-molecular-weight antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"10","key":"2026091609083773500_cit35","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.phymed.2013.03.002","article-title":"Pyranocycloartobiloxanthone\nA, a novel gastroprotective compound\nfrom Artocarpus obtusus Jarret, against ethanol-induced acute gastric\nulcer in vivo","volume":"20","author":"Sidahmed","year":"2013","journal-title":"Phytomedicine"},{"issue":"11","key":"2026091609083773500_cit36","doi-asserted-by":"publisher","first-page":"5167","DOI":"10.1039\/D2FO03693B","article-title":"Gastroprotective\neffects of ginsenoside Rh4 against\nethanol-induced gastric mucosal injury by inhibiting the MAPK\/NF-\u03baB\nsignaling pathway","volume":"14","author":"Wu","year":"2023","journal-title":"Food Funct."},{"issue":"12","key":"2026091609083773500_cit37","doi-asserted-by":"publisher","first-page":"22553","DOI":"10.3390\/molecules201219867","article-title":"Anti-Ulcerogenic Properties of Lycium\nchinense Mill Extracts against Ethanol-Induced Acute Gastric Lesion\nin Animal Models and Its Active Constituents","volume":"20","author":"Olatunji","year":"2015","journal-title":"Molecules"},{"issue":"6","key":"2026091609083773500_cit38","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062078","article-title":"Protective Effects of Small-Molecule\nOligopeptides Isolated from Tilapia Fish Scale on Ethanol-Induced\nGastroduodenal Injury in Rats","volume":"13","author":"Hu","year":"2021","journal-title":"Nutrients"},{"issue":"7","key":"2026091609083773500_cit39","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1039\/D2FO03735A","article-title":"Phenolic-rich\nextract of Nopalea cochenillifera attenuates gastric lesions induced\nin experimental models through inhibiting oxidative stress, modulating\ninflammatory markers and a cytoprotective effect","volume":"14","author":"da Silva","year":"2023","journal-title":"Food Funct."},{"issue":"1","key":"2026091609083773500_cit40","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal\ndefense and cytoprotection:\nBench to bedside","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"issue":"1-6","key":"2026091609083773500_cit41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0928-4257(01)00003-1","article-title":"Role of\ncyclooxygenase isoforms in gastric mucosal defence","volume":"95","author":"Peskar","year":"2001","journal-title":"J. Physiol. (Paris)"},{"key":"2026091609083773500_cit42","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1003627","article-title":"Antarctic\nkrill (Euphausia superba)\noil modulatory effects on ethanol-induced acute injury of the gastric\nmucosa in rats","volume":"9","author":"Huang","year":"2022","journal-title":"Front. Nutr."},{"issue":"1","key":"2026091609083773500_cit43","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2174\/1381612013398491","article-title":"Role of\nnitric oxide in gastrointestinal inflammatory and ulcerative diseases:\nPerspective for drugs development","volume":"7","author":"M D Barrachina","year":"2001","journal-title":"Curr. Pharm.\nDes."},{"issue":"2","key":"2026091609083773500_cit44","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1165\/rcmb.2008-0091TR","article-title":"Cyclic AMP\n- Master regulator of innate immune cell function","volume":"39","author":"Serezani","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"11","key":"2026091609083773500_cit45","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1016\/j.yexcr.2007.03.036","article-title":"Prostaglandins\nPGE2\nand PGI2 promote endothelial barrier enhancement via PKA- and Epac1\/Rap1-dependent\nRac activation","volume":"313","author":"Birukova","year":"2007","journal-title":"Exp. Cell Res."},{"key":"2026091609083773500_cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106210","article-title":"The role\nof JAK\/STAT signaling pathway and its inhibitors in diseases","volume":"80","author":"Xin","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"2026091609083773500_cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s44466-025-00014-0","article-title":"NF-\u03baB:\nmaster regulator of\ncellular responses in health and disease","volume":"1","author":"Hoffmann","year":"2025","journal-title":"Immun.\nInflammation"},{"issue":"49","key":"2026091609083773500_cit48","doi-asserted-by":"publisher","first-page":"17432","DOI":"10.1073\/pnas.1418399111","article-title":"Protein kinase IKK\u03b2-catalyzed\nphosphorylation of IRF5 at Ser462\ninduces its dimerization and nuclear translocation in myeloid cells","volume":"111","author":"Lopez-Pelaez","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"2026091609083773500_cit49","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/fcp.12255","article-title":"Gastroprotective\neffect of esculin on ethanol-induced gastric lesion in mice","volume":"31","author":"Li","year":"2017","journal-title":"Fundam. Clin. Pharmacol."},{"key":"2026091609083773500_cit50","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.carbpol.2018.03.061","article-title":"Radical\nscavenging\nactivity of sulfated Bupleurum chinense polysaccharides and their\neffects against oxidative stress-induced senescence","volume":"192","author":"Tong","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"2026091609083773500_cit51","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1021\/acs.jafc.2c00005","article-title":"Walnut-Derived Peptide\nEnhances Mitophagy via JNK-Mediated\nPINK1 Activation to Reduce Oxidative Stress in HT-22 Cells","volume":"70","author":"Yang","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"2026091609083773500_cit52","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S1534-5807(01)00055-7","article-title":"The role of dynamin-related\nprotein 1, a mediator of mitochondrial fission, in apoptosis","volume":"1","author":"Frank","year":"2001","journal-title":"Dev. Cell"},{"issue":"1","key":"2026091609083773500_cit53","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5483\/BMBRep.2008.41.1.011","article-title":"The role of mitochondria in apoptosis","volume":"41","author":"Jeong","year":"2008","journal-title":"BMB Rep."},{"key":"2026091609083773500_cit54","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The Role of Mitochondria in Apoptosis","volume":"43","author":"Wang","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"2026091609083773500_cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117241","article-title":"Gancao Xiexin\nDecoction inhibits gastric carcinoma proliferation and migration by\nregulating the JAK2\/STAT3 signalling pathway","volume":"319","author":"Yang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"2026091609083773500_cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2023.102145","article-title":"Liuwei Anxiao San\nprotects gastric mucosa from gastric ulcer in rats by regulating the\nJAK2\/STAT3 pathway","volume":"83","author":"Qu","year":"2023","journal-title":"Tissue Cell"},{"issue":"6","key":"2026091609083773500_cit57","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14060727","article-title":"Restorative\nEffects of Synbiotics\non Colonic Ultrastructure and Oxidative Stress in Dogs with Chronic\nEnteropathy","volume":"14","author":"Sahoo","year":"2025","journal-title":"Antioxidants"},{"issue":"6","key":"2026091609083773500_cit58","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1039\/D0FO02947E","article-title":"Protective effects\nof polysaccharides from Panax ginseng on acute gastric ulcers induced\nby ethanol in rats","volume":"12","author":"Liu","year":"2021","journal-title":"Food Funct."},{"key":"2026091609083773500_cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117829","article-title":"Protective effect against gastric\nmucosa injury of a sulfated agaran from Acanthophora spicifera","volume":"261","author":"Pereira Ju\u0301nior","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"7","key":"2026091609083773500_cit60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072577","article-title":"Protective Effect of\nOcotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus,\nagainst Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted\nMetabolomics","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2026091609083773500_cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124143","article-title":"Construction of\ndiallyltrisulfide nanoparticles for\nalleviation of ethanol-induced acute gastric injury","volume":"657","author":"Li","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"8","key":"2026091609083773500_cit62","doi-asserted-by":"publisher","first-page":"4859","DOI":"10.1007\/s10787-025-01885-w","article-title":"Gastroprotective\neffect of Arabincoside B isolated from Caralluma arabica against ethanol-induced\ngastric injury via modulating oxidative stress\/SP\/NK-1R\/NF-\u03baB\nloop","volume":"33","author":"Ali","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"1-6","key":"2026091609083773500_cit63","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0928-4257(01)00015-8","article-title":"Gastric mucosal integrity: gastric\nmucosal blood flow\nand microcirculation. An overview","volume":"95","author":"Abdel-Salam","year":"2001","journal-title":"J. Physiol.\n(Paris)"},{"issue":"2","key":"2026091609083773500_cit64","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1039\/D0FO02677H","article-title":"Hunan insect tea polyphenols provide protection against\ngastric injury\ninduced by HCl\/ethanol through an antioxidant mechanism in mice","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct."},{"issue":"5","key":"2026091609083773500_cit65","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.3892\/ijo.2015.3160","article-title":"The JAK\/STAT signaling\ncascade in gastric carcinoma","volume":"47","author":"Khanna","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"2","key":"2026091609083773500_cit66","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00281-012-0353-5","article-title":"The role of PGE2-associated inflammatory responses\nin gastric cancer development","volume":"35","author":"Oshima","year":"2013","journal-title":"Semin. Immunopathol."},{"issue":"2","key":"2026091609083773500_cit67","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.062","article-title":"EGF and BMPs Govern Differentiation and Patterning\nin Human Gastric Glands","volume":"161","author":"Wo\u0308lffling","year":"2021","journal-title":"Gastroenterology"},{"key":"2026091609083773500_cit68","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cbi.2016.10.021","article-title":"Gastroprotective\neffects of Kangfuxin-against ethanol-induced gastric ulcer via attenuating\noxidative stress and ER stress in mice","volume":"260","author":"Chen","year":"2016","journal-title":"Chem.-Biol.\nInteract."},{"issue":"1","key":"2026091609083773500_cit69","first-page":"39","article-title":"Effects of reactive oxygen species\naction on gastric mucosa in various models of mucosal injury","volume":"53","author":"Kwiecien","year":"2002","journal-title":"J. Physiol. Pharmacol."},{"issue":"19","key":"2026091609083773500_cit70","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1080\/10408398.2021.1992606","article-title":"Role of bioactive peptides derived\nfrom food proteins in programmed cell death to treat inflammatory\ndiseases and cancer","volume":"63","author":"Deng","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c09805","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/36\/28526\/68394670\/acs.jafc.6c09805.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/36\/28526\/68394670\/acs.jafc.6c09805.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:13:22Z","timestamp":1789564402000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/36\/28526\/5421818\/Yeast-Protein-Derived-Peptides-Protect-against"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":70,"journal-issue":{"issue":"36","published-online":{"date-parts":[[2026,9,4]]},"published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c09805","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]}}}