{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:00:35Z","timestamp":1790776835392,"version":"4.1.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750387"],"award-info":[{"award-number":["2024M750387"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["YQ2023C014"],"award-info":[{"award-number":["YQ2023C014"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH-Z23077"],"award-info":[{"award-number":["LBH-Z23077"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302830"],"award-info":[{"award-number":["32302830"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It is widely believed that neutrophils exert an antibacterial defense through NETs during MRSA infection. However, this study found that during MRSA enteritis, NET DNA released by neutrophils under low-selenium (Se) conditions directly triggers intestinal epithelial pyroptosis and disrupts tight junctions. Following sodium selenite intervention, intestinal selenoprotein transcriptome screening identified selenoprotein S (SelS) as the most significantly downregulated selenoprotein after the MRSA challenge and the most sensitive to Se supplementation recovery. Notably, MRSA alone did not directly induce pyroptosis or tight junction disruption in MODE-K cells, whereas SelS silencing rendered them susceptible to the MRSA-induced damage. Mechanistically, neutrophils cultured under low-Se conditions showed reduced SelS expression and released pathological NET DNA upon MRSA infection, which directly triggered intestinal epithelial pyroptosis and barrier disruption. These findings provide a mechanistic basis for Se-based nutritional intervention in MRSA-associated enteritis and offer potential therapeutic targets for nonantibiotic strategies.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c10442","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:01:38Z","timestamp":1789736498000},"page":"30167-30185","source":"Crossref","is-referenced-by-count":0,"title":["Selenium Supplementation\nAttenuates NET DNA-Mediated\nIntestinal Epithelial Pyroptosis and Intestinal Barrier Injury in\nMRSA Enteritis via Upregulating Selenoprotein S"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7381-4281","authenticated-orcid":true,"given":"Qianru","family":"Chi","sequence":"first","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]},{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaran","family":"Yang","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Pi","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Chen","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-7024","authenticated-orcid":true,"given":"Yanhua","family":"Li","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, P. R. China, 150030"]},{"name":"Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development , ,","place":["Harbin, P. R. China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"8","key":"2026093009080278300_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14080771","article-title":"Methicillin-Resistant Staphylococcus aureus (MRSA): Resistance, Prevalence, and Coping\nStrategies","volume":"14","author":"Li","year":"2025","journal-title":"Antibiotics-Basel"},{"key":"2026093009080278300_cit2","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.2147\/IDR.S459708","article-title":"Epidemiological\nStudy on Case Definition of Methicillin-Resistant Staphylococcus aureus Enteritis","volume":"17","author":"Yagi","year":"2024","journal-title":"Infect. Drug\nResist."},{"key":"2026093009080278300_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115994","article-title":"Protective effect of 13-methylberberine\nagainst mouse enteritis caused\nby MRSA","volume":"304","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"2026093009080278300_cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102380","article-title":"Establishment\nand application of nano-liposomes system for targeted therapy of methicillin-resistant Staphylococcus aureus enteritis","volume":"35","author":"Yang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"2026093009080278300_cit5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jare.2024.06.028","article-title":"Ginsenoside Rh4 inhibits colorectal\ncancer via the modulation of gut microbiota-mediated bile acid metabolism","volume":"72","author":"Bai","year":"2025","journal-title":"J. Adv. Res."},{"issue":"7883","key":"2026093009080278300_cit6","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41586-021-03986-2","article-title":"Unravelling\nthe collateral damage of antibiotics on gut bacteria","volume":"599","author":"Maier","year":"2021","journal-title":"Nature"},{"issue":"9","key":"2026093009080278300_cit7","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1007\/s11427-022-2274-7","article-title":"Selenium-enriched Cardamine violifolia protects against\nsepsis-induced intestinal injury by regulating mitochondrial fusion\nin weaned pigs","volume":"66","author":"Wang","year":"2023","journal-title":"Sci. China:Life Sci."},{"key":"2026093009080278300_cit8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.aninu.2021.07.001","article-title":"Dietary nano-selenium\nalleviated intestinal damage of juvenile grass carp (Ctenopharyngodon idella) induced by high-fat diet:\nInsight from intestinal morphology, tight junction, inflammation,\nanti-oxidization and intestinal microbiota","volume":"8","author":"Liu","year":"2022","journal-title":"Anim. Nutr."},{"key":"2026093009080278300_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101102","article-title":"Surface\nchemistry engineered selenium nanoparticles as bactericidal\nand immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection","volume":"76","author":"Bu","year":"2024","journal-title":"Drug Resistance Updates"},{"issue":"1","key":"2026093009080278300_cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-026-04484-y","article-title":"Biosynthesis\nand antibacterial activity of selenium nanoparticles using Pseudomonas aeruginosa and Bacillus pumilus RMO6","volume":"21","author":"Heidari","year":"2026","journal-title":"Discover Nano"},{"issue":"7","key":"2026093009080278300_cit11","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2024.9250158","article-title":"Selenium nanoparticles biosynthesized\nby Eurotium cristatum with antimicrobial\nactivity","volume":"14","author":"Li","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"issue":"1","key":"2026093009080278300_cit12","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics18010014","article-title":"Biogenic\nSelenium Nanoparticles from Lactiplantibacillus plantarum as a Potent Antimicrobial\nAgent Against Methicillin-Resistant Staphylococcus aureus","volume":"18","author":"Kim","year":"2026","journal-title":"Pharmaceutics"},{"key":"2026093009080278300_cit13","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.freeradbiomed.2013.11.001","article-title":"Selenoprotein S\nis a marker but not a regulator of endoplasmic reticulum stress in\nintestinal epithelial cells","volume":"67","author":"Speckmann","year":"2014","journal-title":"Free Radicals Biol.\nMed."},{"issue":"15","key":"2026093009080278300_cit14","doi-asserted-by":"publisher","first-page":"5903","DOI":"10.7150\/thno.97005","article-title":"Selenoprotein S maintains intestinal homeostasis in ulcerative colitis\nby inhibiting necroptosis of colonic epithelial cells through modulation\nof macrophage polarization","volume":"14","author":"Yao","year":"2024","journal-title":"Theranostics"},{"issue":"12","key":"2026093009080278300_cit15","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1038\/s41590-024-02006-5","article-title":"The diverse roles\nof neutrophils from protection to\npathogenesis","volume":"25","author":"Herro","year":"2024","journal-title":"Nat. Immunol."},{"issue":"3","key":"2026093009080278300_cit16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.chom.2025.02.003","article-title":"Mitochondria\nsense bacterial lactate\nand drive release of neutrophil extracellular traps","volume":"33","author":"Wise","year":"2025","journal-title":"Cell Host Microbe"},{"issue":"1-3","key":"2026093009080278300_cit17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12016-024-09004-3","article-title":"Neutrophils\nin Atopic Dermatitis","volume":"67","author":"Chiang","year":"2024","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"2026093009080278300_cit18","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1016\/j.csbj.2021.06.012","article-title":"Staphylococcus aureus induces neutrophil extracellular traps (NETs) and neutralizes their\nbactericidal potential","volume":"19","author":"Speziale","year":"2021","journal-title":"Comput. Struct. Biotechnol.\nJ."},{"issue":"1","key":"2026093009080278300_cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-026-00979-9","article-title":"Staphylococcus aureus biofilm extracellular DNA neutralizes\nthe antimicrobial activity of histone H3","volume":"12","author":"Rana","year":"2026","journal-title":"npj\nBiofilms Microbiomes"},{"key":"2026093009080278300_cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1250458","article-title":"Oral exposure to Staphylococcus aureus enterotoxin B could promote the Ovalbumin-induced\nfood allergy by enhancing the activation of DCs and T cells","volume":"14","author":"Yuan","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"2026093009080278300_cit21","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2024.9250360","article-title":"Reuterin-producing\nLimosilactobacillus reuteri with\nglycerol metabolism ameliorates Staphylococcus aureus-induced intestinal inflammation and dysfunction without gut microbiota\ndependent","volume":"15","author":"Li","year":"2026","journal-title":"Food Sci. Hum. Wellness"},{"key":"2026093009080278300_cit22","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.802409","article-title":"The Host CYP1A1-Microbiota\nMetabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Microbiol."},{"key":"2026093009080278300_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101295","article-title":"Staphylococcus aureus manipulates\nosteocytes to cause\npersistent chronic osteomyelitis and antibiotic resistance via pyroptosis\npathway suppression","volume":"84","author":"Cai","year":"2026","journal-title":"Drug Resistance Updates"},{"issue":"11","key":"2026093009080278300_cit24","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1038\/s41418-024-01343-0","article-title":"GSDME promotes MASLD\nby regulating pyroptosis, Drp1 citrullination-dependent mitochondrial\ndynamic, and energy balance in intestine and liver","volume":"31","author":"Zhu","year":"2024","journal-title":"Cell Death Differ."},{"key":"2026093009080278300_cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2025.128388","article-title":"Meningitic Escherichia coli disrupts the blood-brain barrier\nthrough pyroptosis and tight junction degradation and NLRP6 deficiency\naggravates infection outcomes","volume":"303","author":"Jia","year":"2026","journal-title":"Microbiol. Res."},{"issue":"1","key":"2026093009080278300_cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-026-03031-z","article-title":"Excessive pyroptosis\nmediates the exacerbation of pneumonia\ncaused by low-lethality influenza virus and secondary MRSA co-infection","volume":"12","author":"Tian","year":"2026","journal-title":"Cell Death Discovery"},{"issue":"1","key":"2026093009080278300_cit27","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/imm.70023","article-title":"Pyroptosis Drives\nthe Impairment of Colonic Barrier Integrity During Toxoplasma Gondii\nChronic Infection","volume":"177","author":"Tian","year":"2026","journal-title":"Immunology"},{"issue":"13","key":"2026093009080278300_cit28","doi-asserted-by":"publisher","DOI":"10.3390\/cells13131140","article-title":"The Barrier\nDisruption and Pyroptosis of Intestinal\nEpithelial Cells Caused by Perfringolysin O (PFO) from Clostridium perfringens","volume":"13","author":"Liu","year":"2024","journal-title":"Cells"},{"key":"2026093009080278300_cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102003","article-title":"Roles of selenoprotein\nS in reactive oxygen species-dependent neutrophil\nextracellular trap formation induced by selenium-deficient arteritis","volume":"44","author":"Chi","year":"2021","journal-title":"Redox Biol."},{"key":"2026093009080278300_cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.105930","article-title":"In vitro and\nin silico analyses reveal the toxicity of metolachlor to grass carp\nhepatocytes and the antagonism of melatonin","volume":"202","author":"Chi","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"2026093009080278300_cit31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.omtn.2019.08.003","article-title":"lnc-3215 Suppression\nLeads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart\nLesion via the lnc-3215-miR-1594-TNN2 Pathway","volume":"18","author":"Yang","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"2026093009080278300_cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07395-5","article-title":"Piezo1-directed neutrophil\nextracellular traps regulate macrophage differentiation during influenza\nvirus infection","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"2026093009080278300_cit33","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-025-10573-7","article-title":"Genomic characterization\nof healthcare-associated ST5MRSA causing severe pseudomembranous enteritis\nin intensive care unit","volume":"25","author":"Sun","year":"2025","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"2026093009080278300_cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-05785-7","article-title":"Loss of Mptx2 alters\nbacteria composition and intestinal\nhomeostasis potentially by impairing autophagy","volume":"7","author":"Yan","year":"2024","journal-title":"Commun. Biol."},{"key":"2026093009080278300_cit35","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.2147\/IDR.S252332","article-title":"Pathways\nof Methicillin-Resistant Staphylococcus aureus in Animal Model: New Insights Regarding Public\nHealth","volume":"13","author":"Hamza","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"2026093009080278300_cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2025.1512343","article-title":"Equine\nneutrophils selectively release neutrophil extracellular\ntraps in response to chemical and bacterial agonists","volume":"12","author":"Sheahan","year":"2025","journal-title":"Front. Vet. Sci."},{"issue":"5","key":"2026093009080278300_cit37","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13050401","article-title":"Neutrophils Expressing\nProgrammed Death-Ligand 1 Play an Indispensable\nRole in Effective Bacterial Elimination and Resolving Inflammation\nin Methicillin-Resistant Staphylococcus aureus Infection","volume":"13","author":"Terasaki","year":"2024","journal-title":"Pathogens"},{"issue":"12","key":"2026093009080278300_cit38","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1134\/S0006297914120025","article-title":"Neutrophil Extracellular\nTraps: Mechanisms of Formation\nand Role in Health and Disease","volume":"79","author":"Vorobjeva","year":"2014","journal-title":"Biochemistry\nMoscow"},{"issue":"1","key":"2026093009080278300_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1170","article-title":"Neutrophil, neutrophil extracellular\ntraps and endothelial cell dysfunction in sepsis","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin. Trans. Med."},{"key":"2026093009080278300_cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103231","article-title":"Cathepsin C from\nextracellular histone-induced M1 alveolar macrophages promotes NETosis\nduring lung ischemia-reperfusion injury","volume":"74","author":"Yu","year":"2024","journal-title":"Redox\nBiol."},{"issue":"6","key":"2026093009080278300_cit41","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1165\/rcmb.2024-0292OC","article-title":"Increased\nCirculating\nExtracellular Superoxide Dismutase Attenuates Platelet-Neutrophil\nInteractions","volume":"72","author":"Sul","year":"2025","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026093009080278300_cit42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00257","article-title":"Phenol-soluble Modulin\na Peptide Toxins from aggressive Staphylococcus aureus induce rapid Formation of neutrophil extracellular Traps through\na reactive Oxygen species-independent Pathway","volume":"8","author":"Bjo\u0308rnsdottir","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"2026093009080278300_cit43","doi-asserted-by":"publisher","first-page":"966","DOI":"10.4049\/jimmunol.2100283","article-title":"Lipoproteins\nfrom Staphylococcus aureus Drive Neutrophil\nExtracellular\nTrap Formation in a TLR2\/1-and PAD-Dependent Manner","volume":"207","author":"Hook","year":"2021","journal-title":"J. Immunol."},{"issue":"2","key":"2026093009080278300_cit44","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020478","article-title":"Antioxidant Strategies\nto Modulate\nNETosis and the Release of Neutrophil Extracellular Traps during Chronic\nInflammation","volume":"12","author":"Hallberg","year":"2023","journal-title":"Antioxidants"},{"issue":"1","key":"2026093009080278300_cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-67579-7","article-title":"Agonist signaling\ndrives neutrophil subpopulations to promote\/inhibit colorectal cancer\nliver metastasis","volume":"17","author":"Xu","year":"2026","journal-title":"Nat. Commun."},{"issue":"5","key":"2026093009080278300_cit46","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1093\/ibd\/izac256","article-title":"Histones\nof Neutrophil Extracellular\nTraps Directly Disrupt the Permeability and Integrity of the Intestinal\nEpithelial Barrier","volume":"29","author":"Lai","year":"2023","journal-title":"Inflammatory Bowel Dis."},{"issue":"9","key":"2026093009080278300_cit47","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1039\/D2FO02707K","article-title":"Hesperetin attenuates sepsis-induced intestinal barrier\ninjury by regulating neutrophil extracellular trap formation via the\nROS\/autophagy signaling pathway","volume":"14","author":"Chen","year":"2023","journal-title":"Food Funct."},{"key":"2026093009080278300_cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110941","article-title":"Neutrophil extracellular\ntraps promote intestinal barrier dysfunction by regulating macrophage\npolarization during trauma\/hemorrhagic shock via the TGF-\u03b2 signaling\npathway","volume":"113","author":"Liu","year":"2024","journal-title":"Cell. Signalling"},{"key":"2026093009080278300_cit49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1190177","article-title":"Who and how,\nDNA sensors in NETs-driven\ninflammation","volume":"14","author":"Aube\u0301","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"2026093009080278300_cit50","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s12276-022-00729-9","article-title":"Cytosolic escape of\nmitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus\npulposus cell pyroptosis","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"2026093009080278300_cit51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.649235","article-title":"ATP Facilitates\nStaphylococcal Enterotoxin O Induced\nNeutrophil IL-1\u03b2 Secretion via NLRP3 Inflammasome Dependent\nPathways","volume":"12","author":"Hou","year":"2021","journal-title":"Front. Immunol."},{"issue":"8","key":"2026093009080278300_cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2025.105269","article-title":"Selenoprotein\nS ablation-mediated pyroptosis contributes to liver damage resulting\nfrom selenium deficiency in chickens","volume":"104","author":"Zhang","year":"2025","journal-title":"Poult.\nSci."},{"key":"2026093009080278300_cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2025.110118","article-title":"Dietary Selenium deficiency\nactivates the NLRP3 inflammasome\nto induce gallbladder pyroptosis by regulating glycolysis and histone\nlactylation through ROS\/HIF-1\u03b1 pathway","volume":"147","author":"An","year":"2026","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"2026093009080278300_cit54","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s10534-025-00754-x","article-title":"The protective effects of selenium\nagainst NLRP3-mediated inflammation and pyroptosis: mechanisms and\nthe potential health benefits","volume":"39","author":"Skalny","year":"2026","journal-title":"Biometals"},{"issue":"2","key":"2026093009080278300_cit55","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04155-y","article-title":"Thioredoxin reductase\n3 suppression promotes colitis\nand carcinogenesis via activating pyroptosis and necrosis","volume":"79","author":"Liu","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"2026093009080278300_cit56","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s12276-026-01656-9","article-title":"Molecular\nmechanisms\nof NLRP3 inflammasome activation","volume":"58","author":"Shin","year":"2026","journal-title":"Exp. Mol.\nMed."},{"key":"2026093009080278300_cit57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158046","article-title":"A Review of\nthe Neutrophil Extracellular Traps (NETs) from Cow, Sheep and Goat\nModels","volume":"22","author":"Worku","year":"2021","journal-title":"Int.J. Mol. Sci."},{"issue":"14","key":"2026093009080278300_cit58","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02127-21","article-title":"PRRSV Infection Induces\nGasdermin D-Driven Pyroptosis of Porcine Alveolar Macrophages through\nNLRP3 Inflammasome Activation","volume":"96","author":"He","year":"2022","journal-title":"J. Virol."},{"key":"2026093009080278300_cit59","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.molimm.2024.02.009","article-title":"The NLRP3\nmolecule is responsible for mediating the pyroptosis of\nintestinal mucosa cells and plays a crucial role in salmonellosis\nenteritis in chicks","volume":"168","author":"Liu","year":"2024","journal-title":"Mol. Immunol."},{"issue":"2","key":"2026093009080278300_cit60","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s12011-019-02017-6","article-title":"Selenium Deficiency\nin Chickens Induces Intestinal Mucosal Injury\nby Affecting the Mucosa Morphology, SIgA Secretion, and GSH-Px Activity","volume":"197","author":"He","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"issue":"S1","key":"2026093009080278300_cit61","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-862874","article-title":"Gender-specific\ndifferences in the expression of selenoproteins\nin mammals","volume":"113","author":"Riese","year":"2005","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"1","key":"2026093009080278300_cit62","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1042\/BJ20091868","article-title":"Selenium controls\nthe sex-specific immune response and selenoprotein expression during\nthe acute-phase response in mice","volume":"429","author":"Stoedter","year":"2010","journal-title":"Biochem. J."},{"key":"2026093009080278300_cit63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1466234","article-title":"Sex-specific NLRP3 activation in neutrophils promotes\nneutrophil recruitment and NETosis in the murine model of diffuse\nalveolar hemorrhage","volume":"15","author":"Jarrot","year":"2024","journal-title":"Front. Immunol."},{"issue":"12","key":"2026093009080278300_cit64","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiaf161","article-title":"Sex differences\nin neutrophil biology","volume":"117","author":"Richter","year":"2025","journal-title":"J. Leukocyte Biol."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c10442","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/38\/30167\/68555247\/acs.jafc.6c10442.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/38\/30167\/68555247\/acs.jafc.6c10442.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:30:49Z","timestamp":1790775049000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/38\/30167\/5432715\/Selenium-Supplementation-Attenuates-NET-DNA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":64,"journal-issue":{"issue":"38","published-online":{"date-parts":[[2026,9,18]]},"published-print":{"date-parts":[[2026,9,30]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c10442","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]}}}