{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:06:56Z","timestamp":1788991616089,"version":"build-2803163510"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rice bran dietary fiber comprises soluble and insoluble fractions, but their differential host, microbial, and metabolic effects remain unclear. We compared RB-SDF, RB-IDF, and their mixture (RB-MIX) at two doses in DSS-induced colitis. All formulations alleviated symptoms, histological injury, barrier dysfunction, endotoxemia, and inflammation, but their relative advantages varied by end point and dose. RB-SDF showed histological protection and the greatest high-dose SCFA output, whereas RB-IDF produced distinct benefits for barrier-related and metabolic end points. RB-MIX remained effective but did not consistently match or exceed the strongest responses of the individual fractions. Microbiota profiling and untargeted metabolomics revealed formulation-dependent remodeling rather than uniform restoration. Disease-axis and factorial analyses further revealed partial shifts toward the CONTROL-associated metabolic profile and substantial contributions of fiber formulation and the formulation-by-dose interaction. These findings support the rational selection and formulation of rice bran fiber ingredients for functional foods.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c10465","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:43:02Z","timestamp":1788244982000},"page":"27657-27671","source":"Crossref","is-referenced-by-count":0,"title":["Soluble, Insoluble,\nand Mixed Rice Bran Dietary Fibers\nGenerate Distinct Host-Microbiota-Metabolome Responses in DSS-Induced\nColitis"],"prefix":"10.1021","volume":"74","author":[{"given":"Chujing","family":"Fu","sequence":"first","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, Zhejiang, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingni","family":"Cheng","sequence":"additional","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, Zhejiang, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7876-2601","authenticated-orcid":true,"given":"Zhichang","family":"Qiu","sequence":"additional","affiliation":[{"name":"University of Massachusetts , , , ,","place":["Amherst, Massachusetts, United States, 01003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ye","sequence":"additional","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, Zhejiang, China, 310058"]},{"name":"Fujian Academy of Agricultural Sciences\/National R&D Center for Edible Fungi Processing , , ,","place":["Fuzhou, China, 350003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Massachusetts , , , ,","place":["Amherst, Massachusetts, United States, 01003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, Zhejiang, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu University of Science and Technology , , , ,","place":["Zhenjiang, Jiangsu Province, China, 212003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-1429","authenticated-orcid":true,"given":"Jie","family":"Tu","sequence":"additional","affiliation":[{"name":"Jiangsu University of Science and Technology , , , ,","place":["Zhenjiang, Jiangsu Province, China, 212003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-2796","authenticated-orcid":true,"given":"Hang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, Zhejiang, China, 310058"]},{"name":"University of Massachusetts , , , ,","place":["Amherst, Massachusetts, United States, 01003"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"issue":"4","key":"2026090917081741100_cit1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","article-title":"Epidemiology\nand Risk Factors for IBD","volume":"12","author":"Ananthakrishnan","year":"2015","journal-title":"Nat. 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Hepatol."},{"issue":"15","key":"2026090917081741100_cit5","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1056\/NEJMoa0904492","article-title":"Infliximab,\nAzathioprine, or Combination Therapy for Crohn\u2019s Disease","volume":"362","author":"Colombel","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"2026090917081741100_cit6","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/s41579-019-0264-8","article-title":"Synthetic\nEcology of the Human Gut Microbiota","volume":"17","author":"Vrancken","year":"2019","journal-title":"Nat. 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Pharmacol.\nTher."},{"issue":"5","key":"2026090917081741100_cit9","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.cmet.2014.07.003","article-title":"Starving\nOur Microbial Self: The Deleterious Consequences\nof a Diet Deficient in Microbiota-Accessible Carbohydrates","volume":"20","author":"Sonnenburg","year":"2014","journal-title":"Cell Metab."},{"issue":"2","key":"2026090917081741100_cit10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jand.2016.09.021","article-title":"Understanding the Physics of Functional\nFibers in the\nGastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring\nMisconceptions about Insoluble and Soluble Fiber","volume":"117","author":"McRorie","year":"2017","journal-title":"J. Acad. Nutr. 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Food Sci.\nNutr."},{"issue":"9","key":"2026090917081741100_cit14","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1111\/1750-3841.15812","article-title":"Positive Intervention\nof Insoluble Dietary Fiber from\nDefatted Rice Bran on Hyperlipidemia in High Fat Diet Fed Rats","volume":"86","author":"Liu","year":"2021","journal-title":"J. Food Sci."},{"issue":"12","key":"2026090917081741100_cit15","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1007\/s13197-013-0925-y","article-title":"Functional a nd Physiological Properties of Total, Soluble, and Insoluble\nDietary Fibres Derived from Defatted Rice Bran","volume":"51","author":"Daou","year":"2014","journal-title":"J. Food Sci. Technol."},{"issue":"6","key":"2026090917081741100_cit16","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.3390\/nu15061528","article-title":"Role of Dietary Defatted Rice Bran\nin the Modulation\nof Gut Microbiota in AOM\/DSS-Induced Colitis-Associated Colorectal\nCancer Rat Model","volume":"15","author":"Tajasuwan","year":"2023","journal-title":"Nutrients"},{"key":"2026090917081741100_cit17","doi-asserted-by":"publisher","first-page":"115231","DOI":"10.1016\/j.foodres.2024.115231","article-title":"Comprehensive Assessment\nof Rice Bran Dietary Fiber on Gut Microbiota Composition and Metabolism\nduring in Vitro Fermentation","volume":"197","author":"Cheng","year":"2024","journal-title":"Food Res. 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Res."},{"issue":"6535","key":"2026090917081741100_cit26","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8433","article-title":"Structure-Based\nDecoupling of the pro- And Anti-Inflammatory\nFunctions of Interleukin-10","volume":"371","author":"Saxton","year":"2021","journal-title":"Science"},{"issue":"28","key":"2026090917081741100_cit27","doi-asserted-by":"publisher","first-page":"2400206","DOI":"10.1002\/advs.202400206","article-title":"Gingerenone A Attenuates\nUlcerative\nColitis via Targeting IL-17RA to Inhibit Inflammation and Restore\nIntestinal Barrier Function","volume":"11","author":"Liang","year":"2024","journal-title":"Adv. Sci."},{"issue":"7","key":"2026090917081741100_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70461","article-title":"Changyanning Ameliorates Dextran Sodium Sulfate-Induced Colitis by\nModulating Gut Microbiota Inflammation and Intestinal Barrier in Mice","volume":"70","author":"Ye","year":"2026","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"2026090917081741100_cit29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/femsec\/fiy201","article-title":"Impact\nof Carbohydrate Substrate Complexity on the Diversity of the Human\nColonic Microbiota","volume":"95","author":"Chung","year":"2018","journal-title":"FEMS Microbiol. Ecol."},{"issue":"10","key":"2026090917081741100_cit30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MIB.0000000000000515","article-title":"Lipocalin-2 Is a Disease\nActivity\nMarker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and\nTNF-\u03b1 and Modulated by IL23R Genotype Status","volume":"21","author":"Stallhofer","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"2026090917081741100_cit31","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.chom.2020.01.006","article-title":"Precision Microbiome Modulation with Discrete Dietary\nFiber Structures Directs Short-Chain Fatty Acid Production","volume":"27","author":"Deehan","year":"2020","journal-title":"Cell Host and Microbe"},{"issue":"1","key":"2026090917081741100_cit32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cell.2019.08.011","article-title":"Interspecies\nCompetition Impacts\nTargeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans","volume":"179","author":"Patnode","year":"2019","journal-title":"Cell"},{"key":"2026090917081741100_cit33","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.carbpol.2017.09.059","article-title":"Gut Microbiota Fermentation of Marine\nPolysaccharides and Its Effects\non Intestinal Ecology: An Overview","volume":"179","author":"Shang","year":"2018","journal-title":"Carbohydr.\nPolym."},{"issue":"5","key":"2026090917081741100_cit34","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cmet.2011.02.018","article-title":"The Microbiome\nand Butyrate Regulate\nEnergy Metabolism and Autophagy in the Mammalian Colon","volume":"13","author":"Donohoe","year":"2011","journal-title":"Cell Metab."},{"issue":"2","key":"2026090917081741100_cit35","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.chom.2021.12.006","article-title":"Polysaccharide Utilization Loci in\nBacteroides Determine\nPopulation Fitness and Community-Level Interactions","volume":"30","author":"Feng","year":"2022","journal-title":"Cell Host and Microbe"},{"issue":"3","key":"2026090917081741100_cit36","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.cell.2022.01.002","article-title":"Strain-Level Fitness in the Gut Microbiome\nIs an Emergent\nProperty of Glycans and a Single Metabolite","volume":"185","author":"Park","year":"2022","journal-title":"Cell"},{"key":"2026090917081741100_cit37","doi-asserted-by":"publisher","first-page":"106949","DOI":"10.1016\/j.fitote.2025.106949","article-title":"Digestion Characteristics of Changyanning\nFormula and Its Regulatory Effect on Fecal Microbiota and Metabolites\nduring in Vitro Fermentation","volume":"187","author":"Huang","year":"2025","journal-title":"Fitoterapia"},{"issue":"7","key":"2026090917081741100_cit38","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1038\/s41564-024-01728-4","article-title":"Microbial\nCommunity-Scale Metabolic\nModelling Predicts Personalized Short-Chain Fatty Acid Production\nProfiles in the Human Gut","volume":"9","author":"Quinn-Bohmann","year":"2024","journal-title":"Nat. Microbiol."},{"issue":"7758","key":"2026090917081741100_cit39","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-Omics\nof the Gut Microbial\nEcosystem in Inflammatory Bowel Diseases","volume":"569","author":"Lloyd-Price","year":"2019","journal-title":"Nature"},{"issue":"2","key":"2026090917081741100_cit40","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut Microbiome Structure and Metabolic\nActivity in Inflammatory Bowel Disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat.\nMicrobiol."},{"issue":"12","key":"2026090917081741100_cit41","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s41575-022-00658-y","article-title":"The Metabolic Nature\nof Inflammatory Bowel Diseases","volume":"19","author":"Adolph","year":"2022","journal-title":"Nat. Rev. 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