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Compound Z1 exhibited significantly higher activity against P. xylostella (LC50 = 0.203 mg\/L) than that of ethiprole (LC50 = 2.88 mg\/L). Compounds Z1, Z8, and Z20 showed over 13-fold higher activity against S. frugiperda (LC50 = 3.38, 2.72, and 2.18 mg\/L) than ethiprole (LC50 = 53.6 mg\/L). Furthermore, compounds Z1, Z4, and Z20 exhibited good activity against O. furnacalis (LC50 = 4.21, 3.20, and 3.30 mg\/L, respectively), with over 7-fold higher potency than ethiprole (LC50 = 30.8 mg\/L). SAR analysis indicated that smaller substituents favored the insecticidal activity. MD simulations and ELISA confirmed that Z1 and tigolaner both target GABA receptors. Transcriptomic analysis further revealed that Z1 treatment disrupted motor protein and neuroactive ligand\u2013receptor interaction pathways, upregulated ELOVL7 and SCD to remodel membrane lipids, and activated GST-mediated detoxification. These multipathway perturbations collectively underpin the insecticidal mechanism of Z1.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c10534","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:02:20Z","timestamp":1788926540000},"page":"29597-29606","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis,\nand Insecticidal Activity of Novel\nFluorine-Containing Pyrazole Benzamide Derivatives"],"prefix":"10.1021","volume":"74","author":[{"given":"Wei","family":"Sun","sequence":"first","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjing","family":"Liao","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yan","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxin","family":"Guo","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-6608","authenticated-orcid":true,"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"6","key":"2026092310072876500_cit1","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1093\/jee\/toz173","article-title":"Global Patterns of Resistance to Bt Crops Highlighting\nPink Bollworm in the United States, China, and India","volume":"112","author":"Tabashnik","year":"2019","journal-title":"J. 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