{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:00:35Z","timestamp":1790776835258,"version":"4.1.0"},"reference-count":151,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1100204"],"award-info":[{"award-number":["2022YFF1100204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["NY-095"],"award-info":[{"award-number":["NY-095"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypertension remains a major risk factor for cardiovascular disease worldwide and a formidable global health challenge. The clinical triumph of peptide-based drugs underscores the immense potential of bioactive peptides in hypertension management. Recently, food-derived antihypertensive peptides have emerged as potential complements to synthetic pharmaceuticals, distinguished by their biocompatibility and bioactivities. Particularly, the rapid development of artificial intelligence has accelerated this process. This review summarizes the diverse sources of antihypertensive peptides and novel preparation strategies to enhance scalability and feasibility in industrial production. Furthermore, we deeply review their multitarget mechanisms and structure\u2013activity relationships. Throughout these procedures, machine learning models facilitate the precise identification and activity prediction of antihypertensive peptides. Given the long-term application value of antihypertensive peptides, future endeavors should integrate advanced biotechnologies and intelligent platforms to accelerate their transformation process from the laboratory to clinical applications.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c10656","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:02:17Z","timestamp":1789606937000},"page":"29791-29811","source":"Crossref","is-referenced-by-count":0,"title":["Food-Derived Antihypertensive\nPeptides: A Comprehensive\nReview of Preparation Strategies, Multitarget Mechanisms, and Machine\nLearning Advancements"],"prefix":"10.1021","volume":"74","author":[{"given":"Qiqian","family":"Feng","sequence":"first","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Guo","sequence":"additional","affiliation":[{"name":"SAMR Defective Product Recall Technical Center , ,","place":["Beijing, China, 100101"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0780-1199","authenticated-orcid":true,"given":"Qiuming","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-1992","authenticated-orcid":true,"given":"Maomao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Wuxi People\u2019s Hospital of Nanjing Medical University , , ,","place":["Wuxi, Jiangsu, China, 214023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-1686","authenticated-orcid":true,"given":"Zhiyong","family":"He","sequence":"additional","affiliation":[{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]},{"name":"Jiangnan University , , , ,","place":["Wuxi, Jiangsu, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"1","key":"2026093009074321900_cit1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41569-024-01062-6","article-title":"Reactive Oxygen\nSpecies in Hypertension","volume":"22","author":"Camargo","year":"2025","journal-title":"Nat. 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Epidemiol."},{"issue":"3","key":"2026093009074321900_cit5","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1093\/ehjqcco\/qcad036","article-title":"Association\nof Cancer\nwith the Risk of Developing Hypertension","volume":"10","author":"Nagasawa","year":"2024","journal-title":"Eur.\nHeart J. Qual. Care Clin. Outcomes"},{"issue":"6","key":"2026093009074321900_cit6","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1158\/1055-9965.EPI-23-1444","article-title":"Hypertension and Risk of Endometrial Cancer:\na Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium\n(e2c2)","volume":"33","author":"Habeshian","year":"2024","journal-title":"Cancer Epidemiol. 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J. Biol. Macromol."},{"key":"2026093009074321900_cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142247","article-title":"Discovery\nof Two Novel ACE Inhibitory Peptides from Soybeans: Stability, Molecular\nInteractions, and in Vivo Antihypertensive Effects","volume":"308","author":"Tang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"18","key":"2026093009074321900_cit42","doi-asserted-by":"publisher","first-page":"9224","DOI":"10.1039\/D4FO02834A","article-title":"Characterization, Mechanisms, Structure-Activity Relationships,\nand Antihypertensive Effects of ACE Inhibitory Peptides: Rapid Screening\nfrom Sufu Hydrolysate","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct."},{"key":"2026093009074321900_cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.140734","article-title":"A Novel ACE\nInhibitory Peptide from Douchi Hydrolysate:\nStability, Inhibition Mechanism, and Antihypertensive Potential in\nSpontaneously Hypertensive Rats","volume":"460","author":"Li","year":"2024","journal-title":"Food Chem."},{"key":"2026093009074321900_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.107390","article-title":"Decoding Bioactivity\nin Pea Proteins: Optimised Hydrolysis Reveals Antioxidant and ACE-Inhibitory\nPeptides","volume":"71","author":"Di Filippo","year":"2025","journal-title":"Food Biosci."},{"key":"2026093009074321900_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.139540","article-title":"Screening\nand Rational Identification\nof a Novel Angiotensin-Converting Enzyme C-Domain Inhibitory Peptide\nfrom Fabaceae Food Peptide Library","volume":"452","author":"Ho","year":"2024","journal-title":"Food Chem."},{"issue":"4","key":"2026093009074321900_cit46","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10040753","article-title":"Fungal\nCell Factories for Efficient and Sustainable\nProduction of Proteins and Peptides","volume":"10","author":"Lu\u0308beck","year":"2022","journal-title":"Microorganisms"},{"key":"2026093009074321900_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2024.103721","article-title":"The Fungal Alternative:\nInsights on Medicinal Mushrooms-Based Protein-Rich Biomasses by Submerged\nFermentation of Agro-Industrial by-Products","volume":"95","author":"Ferrero","year":"2024","journal-title":"Innov. 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